Navigation Links
HUYA Bioscience Int'l Announces Pre-IND Outcome for HBI-3000 - Promising Anti-Arrhythmia Compound Sourced From China
Date:6/17/2008

nic arrhythmia.

Most existing marketed and development-stage anti-arrhythmics have been associated with adverse events such as Torsade de Pointes (TdP - sudden death) or appreciable QTc prolongation (a risk factor for sudden death) in Phase I or preclinical studies. As noted above, in the preclinical studies and the three Phase I studies completed in China, HBI-3000 was well tolerated.

Atrial Fibrillation (AF) is a serious type of arrhythmia found in approximately 2.2 million Americans and about 15 percent of strokes occur in people with AF(1). Ventricular Arrhythmia (VA), a severely abnormal heart rhythm, will cause death unless treated immediately. Ventricular fibrillation (VF), a type of arrhythmia, is responsible for 75 to 85 percent of sudden deaths in persons with heart problems(2).

Currently, anti-arrhythmic drugs are commonly used to treat patients with AF and VA, though in treating patients with VA, most anti-arrhythmics have failed to demonstrate a survival advantage. In some cases they may also carry safety risks, including sudden death. Pre-clinical data developed by HUYA and its Chinese partner, along with the Chinese clinical trial data are encouraging to suggest that HBI-3000 may have a useful role in the treatment of ventricular arrhythmias.

In the United States, HBI-3000 is initially being developed and investigated for use as IV treatment of atrial fibrillation with clinical trials expected to begin in early 2009. "This is a significant area of medicine for which providers need more options to treat patients," continued Gingras. "Researchers in China are developing promising compounds that would fulfill these and other unmet medical needs in the U.S. As we prepare to assemble the data and submit our IND to initiate the Phase I trials, we'll continue to leverage our collaboration and expertise in China and the U.S. It's exciting to think of the amount of time and funding that could be saved by optimizing and streamlining
'/>"/>

SOURCE HUYA Bioscience International
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine technology :

1. Neurocrine Biosciences Completes Petal Study Treatment Phase for Endometriosis
2. Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting
3. Sangamo BioSciences Provides Update on Diabetic Neuropathy Clinical Programs
4. Regado Biosciences Announces Publication in Circulation of Clinical Trial Results of REG1 Anticoagulation System
5. Magellan Biosciences Companies to Feature Automated Products and New Tests for MRSA at the American Society for Microbiology Meeting, Booth 743
6. Ardea Biosciences Presents Preclinical Data on RDEA119 Demonstrating Favorable Anti-Inflammatory Profile for Potential Use in Ulcerative Colitis
7. Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594
8. Ardea Biosciences Appoints John W. Beck Chief Financial Officer, Announces Clinical Development Progress and Reports First Quarter 2008 Financial Results
9. Catalyst Biosciences Selects Drug Development Candidate in Factor VIIa Program for Hemophilia
10. Neurocrine Biosciences Reports First Quarter 2008 Results
11. Ardea Biosciences Presents Data Demonstrating Favorable Pharmacokinetics and Efficacy for Mitogen-Activated ERK Kinase (MEK) Inhibitors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)...  The need to add tissue preserving therapies ... prominently at the 108 th Annual Meeting ... Diego.  According to SonaCare Medical, a leader in ... the need for image-guided technologies to better identify ... minimally invasive ablative treatments, was addressed in the ...
(Date:5/23/2013)... 23, 2013  Every day, their baby stopped breathing, his ... lungs. April and Bryan Gionfriddo watched ... "Quite a few doctors said he had a ... April Gionfriddo , about her now 20-month-old son, ... work, we would take it and run with it." ...
(Date:5/23/2013)... Mass. , May 23, 2013  Hologic, ... HOLX ), a leading developer, manufacturer and supplier ... products, with an emphasis on serving the healthcare ... large-scale observational study in a U.S. clinical practice ... technology (breast tomosynthesis) with conventional 2D mammography alone ...
Breaking Medicine Technology:Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 2Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 3Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 4Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 5Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 6Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 2Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 3Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 4First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 2First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 4
... , , , , , , CAPUA, ... has entered into an agreement with Laboratoires Mayoly Spindler, Chatou ... has successfully completed process development and commenced cGMP manufacture of ... clinical needs. DSM BioSolutions manufactures the lipase compound at its ...
... , ALISO VIEJO, Calif., Dec. 21 Clarient, Inc. (Nasdaq: ... pathologists, oncologists and the pharmaceutical industry, today announced that it ... in an all-stock merger valued at up to $17.6 million, ... agreement are successfully met. As a result of the ...
Cached Medicine Technology:DSM to Manufacture 'MS1819' Lipase Compound for Mayoly Spindler 2DSM to Manufacture 'MS1819' Lipase Compound for Mayoly Spindler 3DSM to Manufacture 'MS1819' Lipase Compound for Mayoly Spindler 4Clarient Acquires Applied Genomics, Inc. 2Clarient Acquires Applied Genomics, Inc. 3Clarient Acquires Applied Genomics, Inc. 4Clarient Acquires Applied Genomics, Inc. 5Clarient Acquires Applied Genomics, Inc. 6Clarient Acquires Applied Genomics, Inc. 7
(Date:5/24/2013)... (PRWEB) May 24, 2013 HCG EZ Drops ... and is excited to announce it’s new weight loss initiative. “We ... we are offering our customers their money back if they don’t ... CEO of HCG EZ Drops. “The HCG Diet consists of ... the 21 pounds in 21 days.” , The controversial, cutting-edge diet ...
(Date:5/24/2013)... The leading retail brand Short Dresses ... prom dresses . Now that is quite unbelievable, especially in ... brand name since its origin. The retailer has already revealed ... this huge discount offer will be an added bonanza for ... privileged to announce that Short Dresses is to offer different ...
(Date:5/23/2013)... (PRWEB) May 23, 2013 Over the ... been gradually transforming, which has affected the Medical ... debt and seeking regular hours, more young physicians are ... or other medical groups,” says IBISWorld industry analyst Anna ... reimbursement pressure, a number of older physicians are selling ...
(Date:5/23/2013)... High blood glucose is associated with poor outcomes in ... to control hyperglycemia is a common practice in hospitals. ... benefit and even shows harms associated with the use ... (ACP) Clinical Guidelines Committee in a new evidence-based paper ... Medical Quality . , "Clinicians caring for hospitalized patients ...
(Date:5/23/2013)... 2013 The sodium theory ... and B. Katz in the early 1950s, after their ... of sodium and potassium ions in nerve functions ... acquisition techniques have known amazing developments. In The Sodium ... give an account of the latest developments in the ...
Breaking Medicine News(10 mins):Health News:short prom dresses Offers Abnormally Low Discount on Its New Collections 2Health News:Medical Group Practice Management in the US Industry Market Research Report Now Available from IBISWorld 2Health News:Medical Group Practice Management in the US Industry Market Research Report Now Available from IBISWorld 3Health News:ACP issues recommendations for management of high blood glucose in hospitalized patients 2Health News:Yves Pichon’s New Book Presents Latest Neurophysiological Discoveries 2Health News:Yves Pichon’s New Book Presents Latest Neurophysiological Discoveries 3
... The Journal of the American Dental Association ... in publishing a global theme issue on poverty ... the worlds biomedical publications., The Council of Science ... simultaneous publication by science journals throughout the world ...
... Medical Center may have solved the mystery surrounding the healing ... interest in gold salts as a treatment for rheumatoid arthritis ... gold salts in the early 1900s to ease the pain ... a high cost: The shots took months to take ...
... Sponsored by Health Improvement Institute, Consumer,Reports WebWatch, ... is organizing a one-day workshop Monday, November 12,to ... Internet., Held at the Hyatt Regency Hotel ... health experts, representatives of relevant,organizations, and consumers to ...
... Pre-Emption in Riegel v. Medtronic, Inc., WASHINGTON, Oct. ... Medical Technology Association,(AdvaMed) filed a joint amicus brief Friday ... v. Medtronic, Inc. arguing that the FDA should,continue to ... states that,no other legislative or regulatory entity is better ...
... J. Halamandaris,President of the National Association for Home Care ... the power of caring, both at home,and in their ... Hospice Month., "It is highly appropriate that we ... nurses, therapists, aides and other providers who have chosen,to ...
... publisher, is proud to be participating in a Global ... by the Council of Science Editors. , The CSE ... interest and debate on the crucial matters of poverty ... developed and developing countries will simultaneously publish papers on ...
Cached Medicine News:Health News:Journal of the American Dental Association spotlights poverty 2Health News:Scientists discover how gold eases pain of arthritis 2Health News:Can the Web Transform the U.S. Healthcare System? 2Health News:Can the Web Transform the U.S. Healthcare System? 3Health News:Amicus Brief Filed with U.S. Supreme Court in Riegel v. Medtronic, Inc. 2Health News:U.S. Celebrates National Home Care and Hospice Month in November 2Health News:9 SAGE journals participate in global theme issue on poverty and human development 2
Ultra-Slip™ endotracheal tube guide for single-patient use only., ,Caution: Not MRI Compatible....
FlexiSlip™ Plastic coated malleable metal core. Single use, Sterile, Latex Free. Soft distal tip flexes to reduce risk of trauma to patient. Malleable metal core is easy to shape. Low friction ...
Endotracheal Tube Stylet- Adult, Copper, Malleable, Non-Sterile, Latex Free, Suitable for tubes 5.0 mm I.D. or larger....
... Prevent dental and soft tissue damage. Used ... X-ray. Light-guided intubation is based upon the ... neck. This technique takes advantage of the ... the esophagus. A well-defined, circumscribed glow can ...
Medicine Products: