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HUYA Bioscience Int'l Announces First Pre-IND Outcome for a Development Stage Compound Sourced From China - HBI-8000, Promising New Cancer Compound
Date:4/14/2008

and pharmaceutical properties that may translate into a superior clinical profile over other HDAC inhibitors currently marketed or in development.

About HDACs

HDAC inhibitors, a new class of cancer drugs, work by controlling how tightly DNA is wound around accessory proteins, histones. By deacetylating (removing an acetyl group from) histones, HDACs appear to promote tighter winding of DNA around histone proteins, which leads to reduced access by gene transcription factors. This results in decreased expression of proteins involved in cell differentiation, cell cycle arrest and apoptotic elimination of damaged cells -- all of which contribute to the development of cancer. HDAC inhibitors are able to restore expression of cancer suppressing genes in a highly selective manner. Treatment with HDAC inhibitors also leads, indirectly, to the suppression of angiogenesis factors, helping to choke off the blood supply to tumors.

Although significant preclinical and clinical activity has been observed with HDAC inhibitors, most of the compounds currently in development have characteristics which may limit their potential for clinical success or broad applicability. In contrast, benzamide class HDAC inhibitors, of which HBI-8000 is a third generation member, have exhibited greater target specificity and fewer serious side effects. In particular, they have the best potential for combination with existing anti-tumor agents.

HUYA's Integrated Co-development Model (ICM)

The global pharmaceutical industry faces a pressing need for new untapped sources of pre-clinical and clinical stage compounds for the drug development process. HUYA was one of the first companies to recognize China's potential to help meet this need through its burgeoning biotechnology industry and world-class talent pool. HUYA pioneered an innovative approach -- the HUYA Integrated Co-development Model -- for partnering with Chinese research institutions and pharmaceutical compa
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SOURCE HUYA Bioscience International
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