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HTI-501 Data Support Commencement of Phase 2 Portion of Clinical Trial
Date:1/31/2012

s of the trial, respectively.

About HTI-501

HTI-501, a recombinant human proteinase known as cathepsin-L (rHuCAT-L), is under development by Halozyme. HTI-501 is being investigated as a potential treatment for dermatologic and aesthetic conditions, as well as other indications. As a conditionally active biologic, HTI-501 is designed to allow local degradation of the collagenous fibrous components of the extracellular matrix at the injection site by tightly controlling the extent and duration of enzyme activity once injected into the body.

About Cellulite

Edematous fibrosclerotic panniculopathy, more commonly known as cellulite, is a condition found in 80-90 percent of post-adolescent women. It presents as a modification of skin topography evident by skin dimpling that occurs mainly on the pelvic region of women. In subcutaneous tissue, fibrous septae, made of types I and III collagen, connect the dermis to the deeper hypodermis. In cellulite, subcutaneous fat cells swell and push upwards while the septae act as an anchor to pull the epidermis downward to form the classic cellulite dimple lesion.

About Halozyme

Halozyme Therapeutics is a biopharmaceutical company dedicated to developing and commercializing innovative products that advance patient care. With a diversified portfolio of enzymes that target the extracellular matrix, the Company's research focuses primarily on a family of human enzymes, known as hyaluronidases, that increase the absorption and dispersion of biologics. Halozyme's pipeline addresses therapeutic areas, such as diabetes, oncology and dermatology that have significant unmet medical need. The Company markets HYLENEX® recombinant (hyaluronidase human injection) and has partnerships with Roche, Baxter, ViroPharma and Intrexon. Halozyme is headquartered in San Diego, CA. For more information on how we are innovating, please visit our corporate website at

SOURCE Halozyme Therapeutics, Inc.
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