Date:3/15/2010

affiliated with the Beth Israel Deaconess Medical Center, and Dr. Barton Haynes of Duke University, used a distinct HIV mosaic vaccine construct that stimulated an immune response emphasizing "Helper T cells"—the kinds of cells required to stimulate and control many aspects of an immune response. This study also showed an increased breadth and depth of anti-HIV immune responses to the vaccine. Both approaches demonstrated that mosaic vaccines improve the immune response against genetically diverse HIV-1 viruses.

"This research indicates that mosaic vaccines represent a promising strategy to expand coverage for genetically diverse pathogens such as HIV-1," Korber said. "The next step is to see whether the improved immune response found in Rhesus monkeys will hold up in humans, so small-scale human safety and immune response studies are being launched at Harvard and at Duke to explore that possibility."

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