Navigation Links
HIV Immunity Study Could Pave Way for Vaccine Development
Date:7/17/2012

LOS ALAMOS, N.M., July 17, 2012 /PRNewswire-USNewswire/ -- Two Los Alamos National Laboratory scientists are among the team recently funded to explore ways to create the precise immune factors needed for effective vaccines against HIV.

The Duke University-led consortium will largely concentrate on inducing broadly neutralizing antibodies that can prevent HIV-1 infection, as well as on generating protective T-cell and innate immune system responses.

"A vaccine-elicited broadly neutralizing antibody response has the potential to block HIV infection; T-cell responses will support that response, and are likely to be able to help control and contain the virus if it breaks through the neutralizing antibody response," said Bette Korber, one of the LANL researchers.

"Some HIV infected individuals eventually make good neutralizing responses during their infection," she noted. The scientists will use the body's occasional ability to create these antibodies as roadmaps for candidate vaccines to stimulate protective antibody responses. Los Alamos scientists from the theoretical biology group will provide analyses and design.

The research funding is provided through the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). NIAID originally established CHAVI in response to recommendations of the Global HIV Vaccine Enterprise, a virtual consortium endorsed by world leaders at a G-8 summit in June 2004.  

That project was directed towards understanding the human immune response to natural HIV infection and to better understand how to approach a vaccine. Los Alamos scientists worked on that grant as well, helping to understand the evolution of the virus at transmission and the dynamics of the early immune response. The new CHAVI-ID grant now will focus on projects that are critical to creating the most effective vaccines for prevention.

Barton Haynes, M.D., will be the Duke director of the seven-year grant for the Duke Center for HIV/AIDS Vaccine Immunology-Immunogen Discovery (CHAVI-ID). Haynes previously led the original Center for HIV/AIDS Vaccine Immunology (CHAVI) consortium, the grant for which just ended in June 2012. Scripps Research Institute was also selected as a second center to receive CHAVI-ID grant funding.            

"We were privileged to have the CHAVI grant over the past seven years, and the work in this consortium helped us understand what needed to be done to make a successful AIDS vaccine," said Haynes, who is also director of the Duke Human Vaccine Institute and the Frederic M. Hanes Professor of Medicine and Immunology. "The CHAVI-Immunogen Discovery grant will be used to learn how to do what we need to do."

Members of the Duke CHAVI-ID Scientific Leadership Group and their participating institutions who submitted the grant with Haynes are Andrew McMichael of Oxford University, UK; George Shaw, University of Pennsylvania; Bette Korber of Los Alamos National Laboratory; Garnett Kelsoe at Duke; and Joseph Sodroski and the late Norman Letvin of Harvard University. Bette Korber and Alan Perelson of Los Alamos will each be leading analysis projects for the new grant at Los Alamos.

Approximately 34 million people are living with HIV/AIDS globally, and the rate of new HIV infections continues to exceed 7,100 per day, according to 2010 data from the Joint United Nations Program on HIV/AIDS.

In the United States, more than a million people are living with HIV/AIDS, and about 21 percent are unaware of their infection. Although AIDS drugs have extended the lives of many in wealthy nations, according to global health experts, an effective HIV vaccine would be a valuable addition to the comprehensive prevention strategies needed to stop the spread of HIV everywhere.

About Los Alamos National Laboratory (www.lanl.gov)

Los Alamos National Laboratory, a multidisciplinary research institution engaged in strategic science on behalf of national security, is operated by Los Alamos National Security, LLC, a team composed of Bechtel National, the University of California, The Babcock & Wilcox Company, and URS Corporation for the Department of Energy's National Nuclear Security Administration.

Los Alamos enhances national security by ensuring the safety and reliability of the U.S. nuclear stockpile, developing technologies to reduce threats from weapons of mass destruction, and solving problems related to energy, environment, infrastructure, health, and global security concerns.


'/>"/>
SOURCE Los Alamos National Laboratory
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Study Finds Utilizing Integrated Medical and Pharmacy Data Improves Ability to Forecast Use of High-cost Specialty Treatments
2. Study Showed Patients Treated With The miraDry© System Experienced 82 Percent Sweat Reduction On Average
3. Asubio Initiates Landmark Clinical Study in Spinal Cord Injury
4. New Veridex Alliance Drives Study Of Circulating Tumor Cells In Men With Metastatic Prostate Cancer
5. Shingles Vaccine is Safe, According to New Study
6. Structural Trends to Profoundly Change Life Sciences Industry, Genpact Study Shows
7. Argos Therapeutics Secures $25 million Series D Financing to Commence Phase 3 ADAPT Study in Patients with Metastatic Renal Cell Carcinoma (mRCC) in Mid-2012
8. Anthera Announces the Completion of Patient Dosing in Phase 2b PEARL-SC Study
9. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
10. Accuray Launches First Study to Compare CyberKnife® SBRT to Surgery and IMRT for Treatment of Early-Stage Prostate Cancer
11. Interim results of VITOBA™ (VImpaT® added to One Baseline AED) Study Presented at the 64th Annual Meeting of the American Academy of Neurology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... Research and Markets has ... 2015-2025: Applications, Technologies, Forecasts" report to their ... Electronics, Smart Skin, Structural Health Monitoring, Composite Smart ... electronics involves electronic and/or electrical components and circuits ... structures such as vehicle bodies or conformally placed ...
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
Breaking Medicine Technology:
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief ... a minimum wage raise to $12 an hour by 2020 and then adjusting it yearly ... lost value of the minimum wage, assure the wage floor does not erode again, and ...
(Date:6/24/2016)... ... 24, 2016 , ... EB Medicine presented its first-ever “Issue ... conference in Ponte Vedra Beach, FL. The awards honor the outstanding work of ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the ...
Breaking Medicine News(10 mins):