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HIV Immunity Study Could Pave Way for Vaccine Development
Date:7/17/2012

LOS ALAMOS, N.M., July 17, 2012 /PRNewswire-USNewswire/ -- Two Los Alamos National Laboratory scientists are among the team recently funded to explore ways to create the precise immune factors needed for effective vaccines against HIV.

The Duke University-led consortium will largely concentrate on inducing broadly neutralizing antibodies that can prevent HIV-1 infection, as well as on generating protective T-cell and innate immune system responses.

"A vaccine-elicited broadly neutralizing antibody response has the potential to block HIV infection; T-cell responses will support that response, and are likely to be able to help control and contain the virus if it breaks through the neutralizing antibody response," said Bette Korber, one of the LANL researchers.

"Some HIV infected individuals eventually make good neutralizing responses during their infection," she noted. The scientists will use the body's occasional ability to create these antibodies as roadmaps for candidate vaccines to stimulate protective antibody responses. Los Alamos scientists from the theoretical biology group will provide analyses and design.

The research funding is provided through the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). NIAID originally established CHAVI in response to recommendations of the Global HIV Vaccine Enterprise, a virtual consortium endorsed by world leaders at a G-8 summit in June 2004.  

That project was directed towards understanding the human immune response to natural HIV infection and to better understand how to approach a vaccine. Los Alamos scientists worked on that grant as well, helping to understand the evolution of the virus at transmission and the dynamics of the early immune response. The new CHAVI-ID grant now will focus on projects that are critical to creating the most effective vaccines for prevention.

Barton Haynes, M.D., will be the D
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SOURCE Los Alamos National Laboratory
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