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Groundbreaking Paper Publishes Long Term Results of a Successful Phase I Clinical Trial Using Autologous Neural Stem Cells to Treat Parkinson's Disease
Date:2/16/2009

oration and treatment of Parkinson's disease. Our original methodology is based on the replication of several steps in human neurogenesis to regenerate millions of mature neurons characterized before transplantation. These steps are essential to establish safety, efficacy and to understand mechanisms of brain repair. The autologous approach mitigates the long term risks associated with allogenic transplants, including infection, inflammatory response, immune rejection, and poor biologic efficacy. In addition, we believe it was the combination of dopaminergic and GABA-ergic neurons that produced the long- lasting motor improvement. This suggests that in humans, Parkinson's disease is more than a chronic dopaminergic dysfunction and involves the GABA-ergic system with its glial environment. The relevance of this discovery cannot be understated because it questions the classical dopaminergic model of Parkinson's disease," says Levesque.

Scientists at NeuroGeneration are planning a larger prospective clinical trial for Parkinson's disease. "It's our hope that this trial will result in the launch of a cost-effective and lasting therapies for the millions of patients suffering from debilitating neurodegenerative disorders," concludes Levesque.

ABOUT NEUROGENERATION:

NeuroGeneration, a biotechnology company, is engaged in the development of biological products for the repair of neurological disorders. The company has completed a Phase I clinical trial for Parkinson's disease using adult derived neural stem cells. It intends to start a Phase II study for the treatment of Parkinson's disease as soon as it received final approval from the FDA. It is also planning Phase I studies for multiple systems atrophy, atypical parkinsonism, stroke, spinal cord and brain injuries, and Alzheimer's disease. The company was founded in 1998 and is headquartered in Los Angeles, California.

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