Navigation Links
Groundbreaking Approach to Predicting Cancer Patients' Response to Treatment Featured in Science Magazine
Date:10/27/2011

BOSTON and CAMBRIDGE, Mass., Oct. 27, 2011 /PRNewswire/ -- A potentially groundbreaking approach to predicting cancer patient response to certain treatments is described today in the electronic version of Science Magazine.  The paper describing the technology, called BH3 profiling, is published by Dr. Anthony Letai and colleagues at Boston's Dana Farber Cancer Institute. The technology assesses the ability of a key part of the cancer cell to respond to chemotherapies. This understanding provides a powerful tool for physicians to gauge ahead of time if a particular cancer treatment will, or will not work in a given patient and can be used to guide the use of existing drugs.

Letai explained, "Our experiments with BH3 profiling demonstrate that understanding of the pretreatment tumor mitochondria can offer valuable predictive information about clinical response.  As such, BH3 profiling has the potential to personalize therapy for cancer patients by predicting the quality of a patient's response to a given treatment."

This capability is in line with an FDA draft guidance document issued in July of this year calling for companion diagnostic tests for targeted therapies.

The job of commercializing this assay has been assumed by Cambridge, MA based Eutropics Pharmaceuticals, where Dr. Letai serves as chair of the SAB. Eutropics has exclusively licensed the technology from Dana Farber. Currently the test is being developed by the company for use in guiding treatments for multiple myeloma and acute myelogenous leukemia patients.

"Eutropics is uniquely positioned to provide this important test that will help cancer patients receive the appropriate treatments," said Dr. Michael Cardone, CEO of Eutropics Pharmaceuticals.  Eutropics' effort to commercialize the BH3 profiling assay is being done in collaboration with Dana Farber Cancer Institute, University of Massachusetts Medical School, M.D. Anderson Cancer Center, and the National Cancer Institute.

About the company:

Eutropics Pharmaceuticals was founded on research and technology that will enable delivery of personalized medicines to patients suffering from cancer. They seek to displace current treatment paradigms by developing novel therapies tailored to an individual's cancer profile identified by the proprietary BH3 profiling diagnostic technology.  This personalized approach utilizing unique diagnostics and therapeutics should result in more effective treatments and reduce unnecessary suffering.  The company is supported by private investors, grants from the NCI, and a loan from the Massachusetts Life Sciences Center.


'/>"/>
SOURCE Eutropics Pharmaceuticals
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. The Leukemia & Lymphoma Society and Cleveland Clinic Taussig Cancer Institute Announce Groundbreaking Partnership to Accelerate Drug Approvals
2. Groundbreaking Study Proves Personalized Diet Based on Genetics Leads to Significant Advances in Long Term Weight Management and Blood Glucose Levels
3. Groundbreaking American Journal of Play from Strong National Museum of Play(R) Premiers July 2008
4. Groundbreaking Paper Publishes Long Term Results of a Successful Phase I Clinical Trial Using Autologous Neural Stem Cells to Treat Parkinsons Disease
5. Lake Hospital System Receives $60,000 Grant for Groundbreaking Music Therapy Study
6. Stand Up To Cancer Awards $73.6 Million for Novel, Groundbreaking Cancer Research
7. UNT Health Science Centers Groundbreaking Research Applied to Protecting Brain After Traumatic Injury
8. Shanghai ChemPartner Is Pleased to be Part of Agios Groundbreaking Cancer Research
9. Groundbreaking Ceremony in Port-au-Prince, Haiti for FilterPure Water Filtration Factory
10. Sensitechs Groundbreaking TempTale(R)4 USB Dry Ice Temperature Monitor Provides Fast, Simple, Efficient Cold Chain Visibility
11. Lotus Pharmaceuticals Reports Groundbreaking Ceremony
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... May 4, 2016 Global ... pages, profiling 09 key companies and supported with ... and in-depth study on the current state of ... of the industry including definitions, classifications, applications and ... is provided for the international market including development ...
(Date:5/3/2016)... Research and Markets has announced ... Therapy Market Outlook 2020" report to their offering. ... ,Recombinant technology has improved significantly in past years due ... in coming years. Many cancer drugs have been developed ... are also expected to be developed with its help. ...
(Date:5/3/2016)... Ariz. , May 3, 2016  As a ... twice contracted rheumatic fever, which damaged his heart. He ... But by June 2013, Shepherd,s heart was giving ... from death. On June 20, 2013, the ... Total Artificial Heart (TAH-t). Like a heart transplant, the ...
Breaking Medicine Technology:
(Date:5/4/2016)... ... ... Recognizing that lifestyle medicine is essential to health and healthcare, About.com ... MD, MPH, president of the American College of Lifestyle Medicine, as their first senior ... said Katz. “There is so much opportunity to add years to lives, and life ...
(Date:5/4/2016)... ... May 04, 2016 , ... The preeminent surgical aftercare ... Dickinson needed following breast cancer surgery. In March 2016, the 61-year-old model and reality ... breast cancer that occurs in the milk ducts, according to an interview with ...
(Date:5/4/2016)... ... May 04, 2016 , ... ... support for knees, ankles, and elbows. Engineered with athletes in mind, OMNIFORCE ... manufacturing (opposed to ineffective circular knitting, common in the industry) produces premium ...
(Date:5/4/2016)... ... May 04, 2016 , ... With the stamp of ... the month of May as National Cancer Research Month. According to the American ... of cancer with predications of one in four Americans dying as a result. , ...
(Date:5/4/2016)... ... 04, 2016 , ... International Conference on Obesity and Chronic ... at Las Vegas. It aims to bring together academicians, scientists, dietitians, surgeons, physicians, ... across the globe; making the conference a perfect platform to share experience and ...
Breaking Medicine News(10 mins):