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Ground Breaking Findings on Understanding Cancer Published in the Current Issue of 'Science'
Date:10/5/2010

ood or also in stool samples are already available

- Extremely promising new compounds target 'M2-PK'

Cancer research is facing a radical change of direction. Cancer cells do not obtain their energy from the breakdown of sugar to carbon dioxide and water, but from energy-rich intermediates of sugar metabolism instead. This confirms the hypothesis developed by the German Noble prizewinner Otto Warburg over 80 years ago, that an altered energy production in human metabolism is characteristic of cancer. The key enzyme 'M2-PK' (PKM2) hereby plays a decisive role, as scientists from Harvard Medical School report in the current issue of the world-renowned specialist magazine 'Science'.

The results of these experiments represent a significant change in direction in the field of cancer research. They also confirm the earlier findings of scientists such as Warburg, Eigenbrodt and Mazurek that tumour cells express their own characteristic isoform of the glycolytic key enzyme pyruvate kinase. M2-PK is the synonym for both the dimeric and also the tetrameric forms of the M2 pyruvate kinase isoenzyme (also known as PKM2). The dimeric form of M2-PK is dominant in tumour cells.

A simple commercial test is already available to measure the biomarker M2-PK in stool and blood

M2-PK in stool samples can be used to screen for bowel (colorectal) cancer and in blood for monitoring therapy response and patient follow-up of various cancers. Effective and simple tests are already available for the detection of this enzyme, which have been developed and patented by the company ScheBo Biotech AG situated in Giessen, Germany, and are already marketed as commercial test kits.

Biomarker M2-PK in stool samples for the screening and early detection of bowel cancer and polyps

Clinical studies from Germany, Great Britain and Ireland, which tested M2-PK in stool samples as a metabolic marker for the early detection
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SOURCE ScheBo Biotech AG
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