Navigation Links
Ground Breaking Findings on Understanding Cancer Published in the Current Issue of 'Science'
Date:10/5/2010

Ground Breaking Findings on Understanding Cancer Published in the Current Issue of... -- GIESSEN, Germany, October 5, 2010 /PRNewswire/ --


Advanced Search Search

  
Close
  1. Send a release
  2. Member sign in
  3. Become a member
  4. For journalists
  5. Global sites
PR Newswire: news distribution, targeting and monitoring
  1. Products & Services
  2. Knowledge Center
  3. Browse News Releases
  4. Contact PR Newswire
Biotechnology, Health Care & Hospitals, Medical Pharmaceuticals, Pharmaceuticals, Clinical Trials & Medical Discoveries Click to view news release full screen  

Ground Breaking Findings on Understanding Cancer Published in the Current Issue of 'Science'

 

GIESSEN, Germany, October 5, 2010 /PRNewswire/ --

- Biomarker 'M2-PK' Identified as Key Enzyme in Cancer Diagnosis and Therapy

- Warburg hypothesis (named after the Nobel prize winner) confirmed

- Cancer cells can be recognised by their metabolism

- Scientists from Harvard Medical School in Boston report on the enzyme 'M2-PK' in a study in the renowned specialist journal 'Science'

- Tests for detecting M2-PK in blood or also in stool samples are already available

- Extremely promising new compounds target 'M2-PK'

Cancer research is facing a radical change of direction. Cancer cells do not obtain their energy from the breakdown of sugar to carbon dioxide and water, but from energy-rich intermediates of sugar metabolism instead. This confirms the hypothesis developed by the German Noble prizewinner Otto Warburg over 80 years ago, that an altered energy production in human metabolism is characteristic of cancer. The key enzyme 'M2-PK' (PKM2) hereby plays a decisive role, as scientists from Harvard Medical School report in the current issue of the world-renowned specialist magazine 'Science'.

The results of these experiments represent a significant change in direction in the field of cancer research. They also confirm the earlier findings of scientists such as Warburg, Eigenbrodt and Mazurek that tumour cells express their own characteristic isoform of the glycolytic key enzyme pyruvate kinase. M2-PK is the synonym for both the dimeric and also the tetrameric forms of the M2 pyruvate kinase isoenzyme (also known as PKM2). The dimeric form of M2-PK is dominant in tumour cells.

A simple commercial test is already available to measure the biomarker M2-PK in stool and blood

M2-PK in stool samples can be used to screen for bowel (colorectal) cancer and in blood for monitoring therapy response and patient follow-up of various cancers. Effective and simple tests are already available for the detection of this enzyme, which have been developed and patented by the company ScheBo Biotech AG situated in Giessen, Germany, and are already marketed as commercial test kits.

Biomarker M2-PK in stool samples for the screening and early detection of bowel cancer and polyps

Clinical studies from Germany, Great Britain and Ireland, which tested M2-PK in stool samples as a metabolic marker for the early detection of bowel cancer, show detection rates between 78% and 97%. That means that in the various studies between 78 and 97 people out of every 100 people with bowel cancer are detected by the M2-PK Stool Test. For polyps >1cm the detection rate lay at 60%; for polyps <1cm it was 25%. The sensitivity for all polyps was 40%.

It is therefore possible to detect bowel polyps as well as bowel tumours with high sensitivity using the biomarker 'M2-PK' in faecal samples, without the need to detect blood in the stool. The result is not affected by diet or specific foods, so a special diet is not required. There are no false positive results from haemorrhoids or other sources of bleeding into the bowel. The test can detect non-bleeding as well as bleeding bowel polyps or tumours. These scientific findings represent a change in direction in the early detection and screening for polyps and cancer of the bowel.

M2-PK in blood as a biomarker for therapy response and patient follow-up in various cancers

Studies from research groups around the world have shown that the concentration of M2-PK is significantly increased in the blood of patients with renal, lung, breast,cervical and gastrointestinal (colon, rectal, gastric [stomach], pancreatic, oesophageal) tumours, as well as melanoma, and correlates with the severity of the disease.

The monitoring of patients receiving therapy is an important application for the detection of M2-PK in EDTA-plasma, which assists with the early recognition of the success or failure of a therapy and in predicting the chances of recovery.

Newly developed compounds which target 'M2-PK' successfully block cancer metabolism

ScheBo Biotech AG is not only a pharmaceutical biotech company which is active in the development of in-vitro diagnostics, but has also already developed extremely promising candidate compounds targeted against 'M2-PK' which sequentially block cancer metabolism. Significant successes in blocking cancer cells have already been achieved in preclinical studies with these innovative compounds. The company is extremely confident that a fundamental breakthrough has been achieved with this new approach, according to board members Dr. Ursula Scheefers-Borchel and Dr. Hans Scheefers.

Source: Science 17 September 2010: Vol. 329. no. 5998, pp. 1492 - 1499; DOI: 10.1126/science.1188015 ScheBo(r)-Biotech AG Tel: +49-641-4996-0 Fax: +49-641-4996-78 E-Mail: info@schebo.com http://www.schebo.com http://www.metabolic-database.com
'/>"/>

SOURCE ScheBo Biotech AG
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. The Leukemia & Lymphoma Society and Cleveland Clinic Taussig Cancer Institute Announce Groundbreaking Partnership to Accelerate Drug Approvals
2. Groundbreaking Study Proves Personalized Diet Based on Genetics Leads to Significant Advances in Long Term Weight Management and Blood Glucose Levels
3. Mitchell, Military TBI Task Force Highlight the Importance of Traumatic Brain Injury Research; Mitchell Endorses Ground Breaking Traumatic Brain Injury Study
4. Groundbreaking American Journal of Play from Strong National Museum of Play(R) Premiers July 2008
5. Groundbreaking Paper Publishes Long Term Results of a Successful Phase I Clinical Trial Using Autologous Neural Stem Cells to Treat Parkinsons Disease
6. Lake Hospital System Receives $60,000 Grant for Groundbreaking Music Therapy Study
7. Ground-Breaking Combination of All-Oral Agents Demonstrates Potential as Hepatitis C Treatment Regimen
8. Stand Up To Cancer Awards $73.6 Million for Novel, Groundbreaking Cancer Research
9. UNT Health Science Centers Groundbreaking Research Applied to Protecting Brain After Traumatic Injury
10. Shanghai ChemPartner Is Pleased to be Part of Agios Groundbreaking Cancer Research
11. Groundbreaking Ceremony in Port-au-Prince, Haiti for FilterPure Water Filtration Factory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... 24, 2016  Global Blood Therapeutics, Inc. (GBT) (NASDAQ: ... novel therapeutics for the treatment of grievous blood-based ... closing of its previously announced underwritten public offering ... public offering price of $18.75 per share. All ... by GBT. GBT estimates net proceeds from the ...
(Date:6/24/2016)... The Academy of Managed Care Pharmacy (AMCP) ... would allow biopharmaceutical companies to more easily share health ... and coverage decisions, a move that addresses the growing ... The recommendations address restrictions in the sharing of ... label, a prohibition that hinders decision makers from accessing ...
(Date:6/24/2016)... , June 24, 2016 ... Market by Type (Standard Pen Needles, Safety Pen Needles), ... (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) ... MarketsandMarkets, This report studies the market for the forecast ... to reach USD 2.81 Billion by 2021 from USD ...
Breaking Medicine Technology:
(Date:6/26/2016)... , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal ... personalized through a fitness app. The fitness app plans to fix the two major problems ... offer a one size fits all type program , They don’t eliminate all ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding emergency ... its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. Ogunleye ... M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. Ogunleye ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
Breaking Medicine News(10 mins):