Navigation Links
Ground-Breaking Combination of All-Oral Agents Demonstrates Potential as Hepatitis C Treatment Regimen
Date:4/25/2009

- Combination of R7227, protease inhibitor, and R7128, nucleoside polymerase inhibitor, shows significant potency in reducing viral load in patients with hepatitis C -

NUTLEY, N.J., BRISBANE, Calif., and PRINCETON, N.J., April 25 /PRNewswire-FirstCall/ -- Roche, InterMune, Inc. (Nasdaq: ITMN) and Pharmasset (Nasdaq: VRUS) today announced the first results from their innovative, interferon-free regimen of direct acting antiviral (DAA) combination therapy for the treatment of patients chronically infected with the hepatitis C virus (HCV)(1). The study combined two oral DAAs, R7227 (also known as ITMN-191) and R7128, for the first time in patients. There were no serious adverse events reported during the 14 days of dosing, and the reductions in levels of HCV RNA were significant.

Results of the INFORM-1 study were presented today during the late-breaker session at the 44th Annual Meeting of the European Association for the Study of the Liver (EASL) in Copenhagen.

The trial, conducted in centers in New Zealand and Australia, is the first to investigate the combination of two oral antiviral medicines in the absence of interferon and ribavirin. The results demonstrated for the first time that the combination of an oral protease inhibitor and an oral nucleoside polymerase inhibitor resulted in significant HCV viral load reduction in patients with HCV. Roche is developing R7227, a protease inhibitor, with InterMune, and R7128, a nucleoside polymerase inhibitor, with Pharmasset.

Further studies will test the activity and safety of the combination of R7227 and R7128 with and without interferon and/or ribavirin. The current standard of care for HCV is a combination of pegylated interferon plus ribavirin, w
'/>"/>

SOURCE Roche; InterMune; Pharmasset
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine technology :

1. CuraGen and TopoTarget Initiate Phase I/II Clinical Trial of Belinostat (PXD101) Combination Therapy for Acute Myeloid Leukemia
2. Abbott and AstraZeneca Announce Selection of Next-Generation Fenofibrate ABT-335 and CRESTOR(R) Fixed-Dose Combination
3. Study Shows Combination Therapy Incorporating AVODART(R) and Tamsulosin Provides Continuous Symptom Improvement Over 2 Years
4. Xeloda XeNA Study Analyses of Xeloda, Docetaxel and Herceptin Combination Therapy for Metastatic Breast Cancer Featured at Major New Breast Cancer Symposium
5. Xeloda(R) XeNA Study Analyses of Xeloda, Docetaxel and Herceptin Combination Therapy for Metastatic Breast Cancer Featured at Major New Breast Cancer Symposium
6. Vion Pharmaceuticals Announces Initiation of a Phase I/II Trial of Cloretazine(R) (VNP40101M) in Combination with Temodar(R) in Adult Brain Tumors
7. New Phase 3 Study in Treatment-Naive Adults with HIV Evaluates Efficacy and Safety of Once-Daily PREZISTA(TM)/ritonavir vs. KALETRA(R) as Part of HIV Combination Therapy
8. New Data Show Ceftobiprole as Effective as Combination Therapy in Treating Patients With Complicated Skin Infections, Including MRSA
9. European Unions CHMP Issues Positive Opinion on PEGINTRON(TM) Combination Therapy for Retreating Hepatitis C Patients Who Failed Previous Therapy
10. Pharmasset Commences Dosing in 28-Day Combination Study of R7128 with Pegasys(R) plus Copegus(R) for Hepatitis C
11. New Data Show Ceftobiprole as Effective as Combination Therapy in Treating Patients with Diabetic Foot Infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/1/2015)... 1, 2015   Intarcia Therapeutics, Inc. today ... as Vice President, Human Resources, reporting directly to ... a new key member of the senior leadership team, ... Leadership Team to assure the Company advances its business, ... its core values and its dynamic culture. Another essential ...
(Date:5/1/2015)... MOUNTAIN VIEW, Calif. , May 1, 2015 /PRNewswire/ ... the United States launch of ... an integrated, fast and easy system for exosome collection ... International Society for Extracellular Vesicles ("ISEV") Annual Meeting, April ... , D.C.  Both products are intended for research use ...
(Date:5/1/2015)... Following yesterday,s release of Center for Medicaid and Medicare services ... need to know: ... programs. , As ... of Medicare and other government programs because it relies on ... drug benefits to enrollees. , Competition and rebates have ...
Breaking Medicine Technology:Intarcia Appoints James P. Brady Vice President, Human Resources 2Intarcia Appoints James P. Brady Vice President, Human Resources 3Intarcia Appoints James P. Brady Vice President, Human Resources 4New Products for Exosome Isolation to mRNA Purification 25 Things to Know About the CMS Part D Data Release 25 Things to Know About the CMS Part D Data Release 3
... (DMC) achieved significant improvements in patient safety and quality ... in costs last year, thanks to efficiencies created by ... nearly all of the DMC,s patient health information via ... in the DMC system, it was the second year ...
... Life Initiative -- STOCKHOLM, August 30, 2010 ... ... var shortURL ... longUrl, so we need to grab the first one. for (var r in data.results) { first_result = ...
Cached Medicine Technology:Electronic Recordkeeping Boosts Patient Safety, Saves DMC More Than $5 Million - For Second Straight Year 2Electronic Recordkeeping Boosts Patient Safety, Saves DMC More Than $5 Million - For Second Straight Year 3Electronic Recordkeeping Boosts Patient Safety, Saves DMC More Than $5 Million - For Second Straight Year 4InspireMD Becomes a Supporting Organization in the Growing Stent for Life Initiative 2InspireMD Becomes a Supporting Organization in the Growing Stent for Life Initiative 3InspireMD Becomes a Supporting Organization in the Growing Stent for Life Initiative 4InspireMD Becomes a Supporting Organization in the Growing Stent for Life Initiative 5InspireMD Becomes a Supporting Organization in the Growing Stent for Life Initiative 6InspireMD Becomes a Supporting Organization in the Growing Stent for Life Initiative 7InspireMD Becomes a Supporting Organization in the Growing Stent for Life Initiative 8
(Date:5/2/2015)... 2015 “ ActOn ” was featured on ... look at the latest and coolest applications on the market ... AppWatch and technology expert, conducted the app review and shared ... with organizations to make a difference. , In this material ... things that aren’t about money, which is why those things ...
(Date:5/2/2015)... “ Peachtree Audio ” was featured on NewsWatch ... the latest and coolest technology products available to consumers. ... NewsWatch, conducted the review and shared with viewers how ... is an important part of people’s lives – and ... royal treatment. Peachtree Audio does just that with high-end ...
(Date:5/2/2015)... ZoomCare, the Portland-based innovator of on-demand ... offer its new healthcare insurance to individuals and small ... Insurance System is the nation’s first health insurance system ... ZOOM+ Personal Health Insurance was ZoomCare’s first such filing ... subject to review and regulation by the Oregon Insurance ...
(Date:5/1/2015)... 01, 2015 Pioneer Millworks, the largest ... latest in their reclaimed wood products at the 27th ... Javits Center in NYC this May. Their newest offerings, ... much anticipated texture and color to North America's platform ... of texture and color in the design world and ...
(Date:5/1/2015)... TROY Healthcare Solutions is proud to ... Group (RUG) Conference in Atlanta, GA from May 6 ... Conference provides a forum for client-to-client presentations, continuing education ... of electronic medical record operations, as well as showcasing ... In addition to sponsoring the event, TROY Healthcare Solutions ...
Breaking Medicine News(10 mins):Health News:An Application to Help People Make a Difference Was Featured on NewsWatch Television 2Health News:Affordable High-End Audio Equipment was Featured on NewsWatch Television 2Health News:ZoomCare Applies to be on Oregon Exchange 2Health News:Intensely Textured Reclaimed Wood to be Unveiled at ICFF in NYC by Pioneer Millworks 2Health News:Intensely Textured Reclaimed Wood to be Unveiled at ICFF in NYC by Pioneer Millworks 3Health News:TROY Healthcare to Exhibit at the Cerner Southeast Regional User Group Conference 2Health News:TROY Healthcare to Exhibit at the Cerner Southeast Regional User Group Conference 3
... know how people become addicted and why they keep using ... 75 patients hospitalized for opioid detoxification told University at Buffalo ... pain. , Another 24 began with a friend,s left-over ... remaining 20 patients said they got hooked on street drugs. ...
... S) is a gas more commonly associated with the smell ... been shown to be present naturally in our bodies and ... in the cavities of joints that reduces friction between the ... may play a role in reducing inflammation in joints. ...
... 2010) -- Casual smokers may think that smoking a few ... new research from physician-scientists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, ... may be doing more harm than people may think. The ... According to a new study published today in the ...
... at an increased risk of prostate cancer diagnosis because of ... genetic mutation that increases risk of the disease, according to ... of the National Cancer Institute. Family history ... other cancers and many epidemiological studies have shown an increased ...
... successful report of using cell-depleted lung as a natural growth ... is presented in a breakthrough article in Tissue Engineering ... Liebert, Inc. ( www.liebertpub.com ). The article is available free ... have the potential to mature into virtually any type of ...
... Steven Reinberg HealthDay Reporter , THURSDAY, Aug. 19 ... a massive recall of eggs linked to salmonella contamination dramatically ... The nationwide salmonella outbreak, which federal officials said was ... has sickened more than 250 people in at least four ...
Cached Medicine News:Health News:Drug addicts get hooked via prescriptions, keep using 'to feel like a better person,' research shows 2Health News:Drug addicts get hooked via prescriptions, keep using 'to feel like a better person,' research shows 3Health News:'Rotten eggs' gas and inflammation in arthritic joints 2Health News:'Rotten eggs' gas and inflammation in arthritic joints 3Health News:Cigarette smoke causes harmful changes in the lungs even at the lowest levels 2Health News:Brothers of prostate cancer patients undergo more diagnostic activities 2Health News:Natural lung material is promising scaffold for engineering lung tissue using embryonic stem cells 2Health News:Nationwide Recall of Eggs Linked to Salmonella Expanded 2Health News:Nationwide Recall of Eggs Linked to Salmonella Expanded 3
Finstruments 96 well washer and Cellwasher. Multi-function with touch programmable display....
... plus simple operation especially ... efficient washing of cells. ... with minimum loss of ... membrane bound labels and ...
The Finstrip 4 is an effective and reliable microplate washer offering high performance, simplicity and ease of use....
... PW 384 has set a standard for ... plates. The instrument not only processes all ... washing to further boost wash performance. This ... short wash times as no transport steps ...
Medicine Products: