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Greater Efficacy on Cognition and Function Over Current Treatments Remain Neurologists' Top Unmet Need in Mild to Moderate Alzheimer's Disease
Date:9/23/2013

BURLINGTON, Mass., Sept. 23, 2013 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that drugs offering a greater effect on cognition and those offering a greater effect on function compared with current treatments remain the top unmet needs in the treatment of mild to moderate Alzheimer's disease (AD), according to surveyed U.S. and European neurologists. Currently available therapies alleviate some cognitive and functional symptoms associated with AD over the short-term, but do not slow disease progression, thus underscoring the remaining unmet need for more efficacious alternatives, which could be either symptomatic or disease-modifying.

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The DecisionBase report entitled Alzheimer's Disease (Mild to Moderate): In an Increasingly Generic Market, What Attributes Can Differentiate Novel Brands in the Minds of Physicians and Payers? also finds that, based on a product profile presented, surveyed U.S. neurologists would prescribe Eli Lilly's emerging anti-beta-amyloid monoclonal antibody solanezumab to a median 15 percent of their mild to moderate AD patients. Interviewed thought leaders are encouraged by a slowing of cognitive decline observed in solanezumab-treated mild AD patients, pooled across two completed, placebo-controlled, Phase III studies, as well as the drug's safety profile, particularly with regard to a low risk of amyloid-related imaging abnormalities.

The report also includes insights from a survey of U.S. managed care organization pharmacy directors, two-thirds of whom indicate they would reimburse a new disease-modifying therapy for the treatment of mild to moderate AD that was priced at
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SOURCE Decision Resources
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