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Grant Awarded to Study Novel Therapies for Muco-Obstructive Diseases Includes Studies on Cempra's Solithromycin (CEM-101) in a Cystic Fibrosis Anti-inflammatory Model
Date:2/12/2013

it mucin formation, reduce inflammation and restore normal airways physiology.  Macrolides, such as azithromycin, have been used to manage these processes in CF patients in the past.  Solithromycin is one of the promising new agents in development, because of its potent anti-inflammatory and anti-mucin activity, that could become an important option for physicians managing CF patients."

Prabhavathi Fernandes , Ph.D., president and chief executive officer of Cempra said, "Solithromycin is emerging as a truly differentiated antibiotic that may become an important option for physicians to treat serious infections such as community-acquired bacterial pneumonia (CABP) or gonococcal infections.  Solithromycin has demonstrated a broad activity spectrum, including against macrolide-resistant strains, in in vitro and in vivo models.  In a Phase 2 trial of patients with gonorrhea, all patients were cured with a single dose of solithromycin.  We have recently initiated a Phase 3 trial of oral solithromycin in CABP patients, which could result in the only macrolide being available as oral monotherapy to treat the disease.  An intravenous (IV) formulation is also in development and we plan to start an IV-to-oral trial in CABP in the second half of 2013.  The two dosing options would enable patients to step down from IV to oral therapy and presumably leave the hospital sooner while staying on the same antibiotic.  Dr. Boucher's research highlights another property of the compound, its anti-inflammatory and anti-mucin production activity.  We look forward to seeing the results of his work."

About Cempra, Inc.
Founded in 2006, Cempra, Inc. is a clinical-stage pharmaceutical company focused on developing antibiotics to meet cri
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