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Grant Awarded to Study Novel Therapies for Muco-Obstructive Diseases Includes Studies on Cempra's Solithromycin (CEM-101) in a Cystic Fibrosis Anti-inflammatory Model
Date:2/12/2013

CHAPEL HILL, N.C., Feb. 12, 2013 /PRNewswire/ -- Cempra, Inc. (Nasdaq: CEMP), a clinical-stage pharmaceutical company focused on developing differentiated antibiotics to meet critical medical needs in the treatment of bacterial infectious diseases, today announced that the National Institute of Allergy and Infectious Diseases (NIAID) awarded a grant to Richard C. Boucher, M.D., Kenan Professor of Medicine and director of the Cystic Fibrosis and Pulmonary Research and Treatment Center at the University of North Carolina School of Medicine, to investigate the anti-inflammatory activity of solithromycin and its effect on mucin secretion in models for cystic fibrosis (CF).

Dr. Boucher's laboratory has studied the role of mucin secretion as well as sodium transport by respiratory epithelium.  His laboratory has also investigated the anti-inflammatory activity of and inhibition of mucin production by azithromycin, a first-generation macrolide antibiotic.  Solithromycin has demonstrated greater potency than azithromycin and other antibiotics against respiratory pathogens as well as stronger anti-inflammatory properties in vitro and in animal models. Dr. Boucher's grant, entitled "Novel Therapies for Muco-Obstructive Lung Diseases," will include tests of solithromycin for its effect on mucus production and for its anti-inflammatory effects in models for CF.

"Treatment of cystic fibrosis patients is complicated by the secretion of excessive mucin, which can trap bacteria, as well as promote airway inflammation, said Dr. Boucher.  "Our research is directed toward identifying compounds that can inhib
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SOURCE Cempra, Inc.
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