Navigation Links
'Good Clostridia' in the Gut Protect from Allergy and Autoimmunity
Date:12/23/2010

BOSTON, Dec. 23, 2010 /PRNewswire/ -- Scientists at the University of Tokyo have discovered that specific gut-dwelling bacteria control key immune cells that combat allergies and autoimmune diseases.  The paper describing these findings was published in today's issue of the journal Science, and technology originating from the work is being advanced by start-up Vedanta Biosciences.  

Dr. Kenya Honda and colleagues initially showed that mice raised in sterile conditions had deficient levels of regulatory T cells in their colon compared to mice colonized with microbes.  "Regulatory T cells are the peace-keepers of the immune system," says Dr. Alexander Rudensky, tri-institutional Professor at the Memorial Sloan-Kettering Institute, the Rockefeller University, and Cornell University, whose previous work helped describe this specialized subset of T cells. "When these cells are missing, the body has trouble putting the brakes on excessive immune responses."

The team of researchers led by Honda then zeroed in on a subset of gut microbes belonging to the Clostridia class that were responsible for triggering production of regulatory T cells. Feeding these "Good Clostridia" to mice prevented the development of allergies and inflammatory bowel disease.  "For millions of years, we have co-evolved with our gut microbes, communicating in an ancient language that may hold critical clues about how autoimmune and infectious diseases develop," said Dr. Ruslan Medzhitov, Professor of Immunobiology at Yale, who authored pioneering studies of the innate immune system. "Researchers like Dr. Honda are making important strides to begin decoding this complex language."

This newly understood beneficial role of certain species of Clostridia may be reminiscent of the opposite effects on health of "good" and "bad" cholesterol.  While some species are harmful pathogens, such as C. difficile, many other Clostridia species are harmless or even beneficial as illustrated by Honda's work. "These surprising findings suggest we should revisit how we view this class of microbes," said Dr. Dan Littman, Professor of Molecular Immunology at NYU, whose previous work shed light on the development of Th17 cells in response to microbial signals. Dr. Littman added that Honda's findings "open up new treatment options for preventing and treating a number of immune-related disorders."

Honda's paper is the latest of a series of recent high profile publications that have followed the launch of the Human Microbiome Project by the NIH, and of similar international efforts aimed at exploring the roles of the human microbiome in health and disease. "The human microbiome is an exciting area of research that may enable a completely new class of therapies," said Dr. Ben Shapiro, Chairman and Senior Partner of PureTech Ventures and former EVP Worldwide Basic & External Research at Merck. "PureTech has made a significant commitment to translating research related to the microbiome, and we have a number of exciting technologies and programs under development."

About Vedanta Biosciences

Vedanta Biosciences, a privately held company, was co-founded by PureTech Ventures and a group of world renowned experts in immunology and microbiology. Vedanta Biosciences' mission is to develop a novel class of therapies that modulate pathways of interaction between the human microbiome and the host immune system. The technology developed by Dr. Honda and colleagues at the University of Tokyo forms the basis of one of several programs being advanced by the company. Dr. Medzhitov is the founding Chairman of the Scientific Advisory Board of Vedanta, and Dr. Rudensky, Dr. Littman, and Dr. Brett Finlay, Professor at the University of British Columbia and author of pioneering studies on molecular mechanisms of host-pathogen interaction, are founding members of the Scientific Advisory Board of Vedanta.  

About PureTech Ventures

PureTech Ventures is a Boston-based venture creation firm specializing in translating breakthrough research from top tier academic institutions into therapies that will significantly impact human health and well-being. PureTech's Partners include entrepreneurs and leaders from the top echelon of pharma, biotech and academia.


'/>"/>
SOURCE Vedanta Biosciences
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Slo-Niacin® Dietary Supplement Shown to Support Good Cholesterol (HDL)
2. Timothy T. Goodnow, Ph.D., Joins Sensors for Medicine and Science, Inc. Board of Directors
3. Nonprescription Drugs Cost Structures Fluctuate with Increased Cost of Goods, According to Kline
4. Goodwin Biotechnology Announces Signing New Biopharmaceutical Development & Manufacturing Agreement
5. OXIS International Executives Interviewed on StockGoodies.com Radio
6. Say Goodbye to Unwanted Love Handles: CoolSculpting by ZELTIQ™ Receives FDA Clearance for Patented, Non-Invasive Cooling Treatment for Fat Reduction
7. BMP Sunstones Hao Wawa (Good Baby) Brand Ranked First Among Chinas Top Three Pediatric Medicine Brands
8. Beijing Goodwill and IBM Team to Improve Detection of Cardiovascular Diseases
9. Purdue Pharma L.P. Provides Free Security Mobiles and Educational Safety Videos to Good Neighbor Pharmacy Members
10. LightLabs C7-XR FD-OCT Intravascular Imaging System Featured on Good Morning America
11. Watson Announces New Program to Help Promote Good Bone Health in Advanced Prostate Cancer Patients on Long-Term Androgen Deprivation Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... 24, 2016 Los innovadores ... del mundo, introduce catéteres para la intervención de ... una compañía global especializada en el suministro de ... su cartera incluyendo productos para tratar la enfermedad ... PTA son los dispositivos de primera entrada de ...
(Date:5/23/2016)... India , May 23, 2016 ... report "Patient Handling Equipment Market by Product (Wheelchair, ... of Care (Bariatric Care, Critical Care, Wound), Accessories ... - Forecast to 2021", published by MarketsandMarkets, the ... USD 17.18 Billion by 2021 at a CAGR ...
(Date:5/23/2016)... Clarifying Vision - Prospects and ... Vision Care What can be expected from ... grow at the fastest rates? This visiongain ... trends, opportunities and prospects. ,Our 190-page ... most lucrative areas in the industry and the future ...
Breaking Medicine Technology:
(Date:5/25/2016)... ... 25, 2016 , ... TransactRx announces the release of enhanced ... service claims by Pharmacy Benefit Managers that were submitted by Retail Clinics and ... Cross Benefit Clearinghouse receives standard professional medical claims submitted from the retail clinic’s ...
(Date:5/25/2016)... ... May 25, 2016 , ... The University of San Francisco ... Professions. She will lead a team of more than 100 full-time faculty and staff, ... role as dean in late August. , Baker comes to USF from the University ...
(Date:5/25/2016)... FLA (PRWEB) , ... May 25, 2016 , ... ... technology to help turn back the hands of time of female aging. The ... and childbirth. Women with symptoms such as leakage, laxity, itchiness and pain have ...
(Date:5/25/2016)... Pine Brook, NJ (PRWEB) , ... May 25, 2016 , ... ... at the 2016 Annual COVD Meeting for their work on visual evoked potential and ... , summarizes recent studies that used the Diopsys® NOVA™ ERG and VEP Vision ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... ... builder, has announced that it will join America's leading engineers at the American ... held at the Georgia World Congress Center. , Engineers, speakers and exhibitors ...
Breaking Medicine News(10 mins):