Navigation Links
Glybera(TM) Shows Long-Term Health Benefits
Date:6/17/2009

AMSTERDAM, The Netherlands, June 18 /PRNewswire-FirstCall/ -- Amsterdam Molecular Therapeutics (Euronext: AMT), a leader in the field of human gene therapy, announced today new data showing that a one-time administration of its lead product GlyberaTM results in significant long-term health benefits. Long-term follow-up data from two clinical trials show that one administration with GlyberaTM brings significant and clinically important reduction in acute pancreatitis in lipoprotein lipase deficient patients. Recurrent acute pancreatitis is the most debilitating complication of lipoprotein lipase deficiency (LPLD) and is associated with significant morbidity and mortality. These data were presented at the International Symposium on Atherosclerosis in Boston, one on the most prestigious conferences on arterial disease well-attended by expert physicians.

The three year follow-up data for the eight patients from the first clinical trial show a statistically significant, tenfold decrease in the incidence of acute pancreatitis. From the second trial in fourteen patients one year data are available showing similar results. The data from both trials also confirm that the treatment is well-tolerated and safe.

AMT has developed Glybera as a treatment for patients with the genetic disorder lipoprotein lipase deficiency. LPLD is an orphan disease for which no treatment exists today. The disease is caused by mutations in the LPL gene, resulting in highly decreased or absent activity of LPL protein in patients. This protein is needed in order to break down large fat-carrying particles that circulate in the blood after each meal. When such particles, called chylomicrons, accumulate in the blood, they may obstruct small blood vessels. Excess chylomicrons result in recurrent and severe acute inflammation of the pancreas, called pancreatitis, the most debilitating complication of LPLD. In the second trial it was observed t
'/>"/>

SOURCE Amsterdam Molecular Therapeutics B.V
Copyright©2009 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related medicine technology :

1. Iomai Trial Shows 100 Percent Immune Response in Elderly Subjects Vaccinated With Novel Travelers Diarrhea Patch Vaccine
2. Study Shows Combination Therapy Incorporating AVODART(R) and Tamsulosin Provides Continuous Symptom Improvement Over 2 Years
3. Largest Study to Date Shows Significant Reductions in Risks of Blood Clots and Reintervention With CYPHER(R) Sirolimus-eluting Coronary Stent Compared to Taxus Stent
4. Kosans Second-Generation Hsp90 Inhibitor, Alvespimycin, Shows 42% Clinical Benefit in Phase 1 HER2-Positive Metastatic Breast Cancer Trial
5. Study Shows Plasma-Derived Human Thrombin Equivalent to Bovine Thrombin in Achieving Hemostasis in Surgery
6. Cleveland Clinic Study Shows the Diabetes Drug Pioglitazone Reduces Risk of Death, Heart Attack and Stroke, but Increases Risk of Heart Failure
7. New Data From Large Safety Analysis of MYCAMINE Shows Favorable Clinical Safety Profile
8. Feeling Anxious or Distracted? New Research Shows a Cup of Tea Could Help
9. New Study Shows Once-Monthly Boniva(R) is as Clinically Effective as Once-Weekly Fosamax(R) at Increasing Bone Mineral Density in Postmenopausal Women With Osteoporosis
10. Study Shows Vasopressin Receptor Antagonist VAPRISOL(R) (Conivaptan Hydrochloride Injection) Significantly Increased Serum Sodium Concentration in Patients with Euvolemic & Hypervolemic Hyponatremia
11. Newly Published Phase II Study Shows the Investigational Drug Vandetanib Prolongs Progression-Free Survival in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2010)... -- LIVESTRONG Quarterly is a ... .  The magazine features profiles of survivors and supporters ... cancer prevention and treatment; and general articles about health, ... survivor, I understand the worries and concerns other survivors ... President and CEO Doug Ulman .  "Our goal ...
(Date:2/9/2010)... Feb. 9 Echo Therapeutics, Inc. (OTC ... tCGM System as a non-invasive, wireless, transdermal continuous glucose ... transdermal drug delivery, announced today that Patrick T. ... be interviewed on " Steve Crowley ,s American Scene ... at 9:34 AM ET and Thursday, ...
(Date:2/9/2010)... Feb. 9 The rapid increase of ... to the CRO and CMO businesses there. However, DS ... manufacturing organization that focuses on fine and pharmaceutical chemicals, ... not only low costs," said Dr. Aaron Shen ... "What makes Chemphy so attractive to our customers? The ...
Breaking Medicine Technology:SPOT ON media and LIVESTRONG(R) Launch LIVESTRONG Quarterly 2SPOT ON media and LIVESTRONG(R) Launch LIVESTRONG Quarterly 3SPOT ON media and LIVESTRONG(R) Launch LIVESTRONG Quarterly 4Echo Therapeutics Chairman and CEO to be Interviewed on Steve Crowley's American Scene Radio Program and Featured on Money Channel Inc. 2Echo Therapeutics Chairman and CEO to be Interviewed on Steve Crowley's American Scene Radio Program and Featured on Money Channel Inc. 3Echo Therapeutics Chairman and CEO to be Interviewed on Steve Crowley's American Scene Radio Program and Featured on Money Channel Inc. 4DS Chemphy Focusing on CRO/CMO Business 2Warady 26amp 3B Davis LLP Named One of 26apos 3BTop 50 Employers for Generation Y Chicago 26apos 3B 60302 1Warady 26amp 3B Davis LLP Named One of 26apos 3BTop 50 Employers for Generation Y Chicago 26apos 3B 60302 2Warady 26amp 3B Davis LLP Named One of 26apos 3BTop 50 Employers for Generation Y Chicago 26apos 3B 60302 3Presentations of Cempra Pharmaceuticals CEM 102 28fusidic acid 29 at the Infectious Diseases Society of America Annual Meeting Highlight Properties T 5811 1Presentations of Cempra Pharmaceuticals CEM 102 28fusidic acid 29 at the Infectious Diseases Society of America Annual Meeting Highlight Properties T 5811 2Presentations of Cempra Pharmaceuticals CEM 102 28fusidic acid 29 at the Infectious Diseases Society of America Annual Meeting Highlight Properties T 5811 3Anti tumor necrosis factor treatment does not increase cancer Risk in RA patients 60299 1Anti tumor necrosis factor treatment does not increase cancer Risk in RA patients 60299 2
... Test to help chronic symptoms such as obesity, IBS, ... researchers from Dubai today reported in the April ,09 ... (The Effect of The ALCAT Test Diet Therapy for ... to achieve goal weight loss by calorie restriction alone ...
... Torax Medical Inc., a medical device company focused on ... has commenced a pivotal clinical trial of its LINX(TM) ... conducted at 15 leading academic and private medical centers ... and effectiveness of the LINX System in patients suffering ...
Other Medicine Technology:Study Confirms: Your Hidden Food Allergies Are Making You Fat 2Study Confirms: Your Hidden Food Allergies Are Making You Fat 3Torax Medical Launches Pivotal Clinical Study of New Acid Reflux Treatment 2
(Date:2/9/2010)... EAST LANSING, Mich.- Michigan State University has launched ... designed to address product counterfeiting- which the FBI ... , The counterfeiting of products- from pharmaceuticals to ... of billions of dollars in global trade and ... the economy, the environment and national security. Terrorist ...
(Date:2/9/2010)... fictional television drama may be more effective in persuading ... program on the same issue, according to a new ... a televised drama about a teen pregnancy felt more ... led to more support for using birth control. , ... difficulties caused by teen pregnancies were unmoved, and had ...
(Date:2/9/2010)... MD -- The first results from a large-scale ... African countries reveal that a high percentage of ... quality and thus may contribute to the growth ... the most virulent form of malaria. The findings, ... Medicines (PQM) Program, a USAID-funded program implemented by ...
(Date:2/9/2010)... The following is a statement by PolicyLink ... childhood obesity epidemic will require the kind of clear-eyed ... ,, "As the First Lady stressed, too many ... soda -- and few healthy food options. For many ... extends far beyond the school yard. Millions of poor ...
(Date:2/9/2010)... The Quantum Foundation is proud to be ... Palm Beach County that will help kids and ... Johnson Foundation (RWJF) recently announced a $360,000 grant ... healthy foods for children and families in Lake Worth ... a rigorous selection process that drew more than 500 proposals ...
Breaking Medicine News(10 mins):Health News:MSU launches first anti-counterfeiting research program 2Health News:MSU launches first anti-counterfeiting research program 3Health News:TV drama can be more persuasive than news program, study finds 2Health News:TV drama can be more persuasive than news program, study finds 3Health News:TV drama can be more persuasive than news program, study finds 4Health News:One-third of antimalarial medicines sampled in 3 African nations found to be substandard 2Health News:One-third of antimalarial medicines sampled in 3 African nations found to be substandard 3Health News:Planting Seeds to Fight Childhood Obesity 2
... stages of pregnancy seems to increase the size of the infant, ... fish // may boost the fetal growth rate during pregnancy. They ... was to deliver a low birth weight baby. ,Researchers ... pregnancies. In women who ate no fish, that rate increased to ...
... Recent research show individuals in lower socioeconomic groups, as measured ... with // higher socioeconomic status, but their stress is more ... those with more education have more days of stress, they ... more than 1,000 adults were interviewed daily for eight days, ...
... link between certain types of bedding and frequent wheezing ... an association between frequent wheezing and synthetic quilts and ... were those reported as foam, sponge, tontine, polyester or ... were classified as synthetic. ,The study also shows ...
... to a complex disorder that combines a chronic activation of ... of T-cells, which are involved in immune response. If the ... weakened immune system is less able to fight infections, and ... drug that suppresses the immune system can delay the onset ...
... caffeine throughout the day is found to be a more ... their findings researchers say, most of the population is using caffeine ... tea in the morning, or three cups on the way to ... falling as the day goes on. ,Nearly 20 male participants ...
... Researchers say they now think they have discovered a way ... called the early // prostate cancer antigen, or EPCA can ... development of cancer . ,However specialists, says one ... of prostate cancer is that PSA levels often fluctuate. They ...
Other Medicine News:
... Healing Shoe offers the most advanced design ... allowing patients to maintain their mobility. Thanks ... even larger portion of the forefoot is ... heads and toes to heal faster. OrthoWedge ...
The choice for inclement weather. This boot provides both closed toe and heel with a moisture resistant vinyl upper....
Ideal for use with thinner casting materials such as polyester or fiberglass. Conforms to any casting material....
This lightweight cast boot features a sturdy canvas upper. The three layer EVA rocker outsole provides excellent shock absorption....
Medicine Products: