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Global Markets for Membrane Technology for Pharmaceuticals
Date:9/6/2012

NEW YORK, Sept. 6, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Global Markets for Membrane Technology for Pharmaceuticals

http://www.reportlinker.com/p0958081/Global-Markets-for-Membrane-Technology-for-Pharmaceuticals.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biopharmaceutical

INTRODUCTION

REASONS FOR DOING THE STUDY Membrane technology is used in all phases of the pharmaceutical development processes, from laboratory research to large-scale pharmaceutical manufacturing. Applications include lab-scale DNA and protein separation and analysis, sample preparation, drug screening, cell culturing and examination, laboratory and process water purification, virus removal, and bench-, pilot-, and production-scale drug manufacturing.

Substantial changes in the pharmaceutical and biopharmaceutical industries have made membrane separations processes an important part of the production of drugs. Membrane separation processes help ensure safety and efficacy of drugs by eliminating contaminants from the laboratory through large-scale production.

This study is an update of a previous report from 2005; it combines bio-pharmaceutical, life science research, and pharmaceutical membrane separation technologies.

STUDY GOALS AND OBJECTIVES This report provides an in-depth analysis of the market for membrane technology in pharmaceuticals, life sciences, and biopharmaceutical applications. Areas in the report include laboratory analysis (e.g., gene and protein analysis, drug candidate screening, laboratory separations and water treatment), biopharmaceutical development (e.g., cell culturing, protein purification, virus removal) and pharmaceutical manufacturing.

Technical and market drivers are considered in evaluating the current value of the technologies and in projecting growth and trends over the next five years. Conclusions are illustrated with statistical information on markets, applications, industry structure and dynamics, and technological developments.

In addition to coverage of membrane technology by type, the report will segment the market by region, including the Americas (U.S., Canada, Latin America, South America); Europe, Middle East, Russia, and Africa (EMRA); and Asia (Japan, Australia/New Zealand, India, China, other Asia-Pacific areas).

SCOPE AND FORMAT The study is intended for individuals requiring an in-depth analysis of the life science, pharmaceutical, and biopharmaceutical membrane separation technology industries. It traces significant developments and forecasts important trends, quantifies the various market sectors, and highlights companies active in those areas.

The report will not cover membranes used in the healthcare or medical diagnostics fields, or membranes used in air and gas venting on medical devices.

INTENDED AUDIENCE

This study will be of interest to membrane device manufacturers, membrane material manufacturers, and venture capitalists and financial institutions involved in the healthcare industry.

METHODOLOGIES AND INFORMATION SOURCES

Both primary and secondary research methodologies were used in preparing this study. A comprehensive literature, patent, and Internet search was conducted. Additionally, business, scientific, and industry journals; government reports; annual reports; conference literature; and Securities and Exchange Commission (SEC) reports were consulted. Industry experts were consulted as necessary.

Growth rates were calculated based on existing and proposed device and equipment sales during the forecast period. Membrane consumables were also taken into account.

Values are given in U.S. dollars; forecasts are made in constant U.S. dollars, and growth rates are compounded. Calculations do not include design nor installation costs or validation expenses.

ANALYST CREDENTIALS

Peggy S Lehr is the BCC Research analyst of this report. Ms. Lehr holds a BS in Journalism from the University of Colorado, Boulder, and an MS in Communication from the University of Denver. Ms. Lehr has worked in the publishing industry for both for-profit and not-for-profit organizations, and she has completed more than 20 reports for BCC.

TABLE OF CONTENTS CHAPTER 1 INTRODUCTION 1

REASONS FOR DOING THE STUDY 1

STUDY GOALS AND OBJECTIVES 1

SCOPE AND FORMAT 1

INTENDED AUDIENCE 2

METHODOLOGIES AND INFORMATION SOURCES 2

ANALYST CREDENTIALS 2

RELATED BCC REPORTS 2

BCC ON-LINE SERVICES 2

DISCLAIMER 3

CHAPTER 2 SUMMARY 5

MEMBRANE TECHNOLOGY AND THE PHARMACEUTICAL INDUSTRY 5

SUMMARY TABLE GLOBAL MARKET FOR MEMBRANE TECHNOLOGY, THROUGH 2016 ($

MILLIONS) 6

SUMMARY FIGURE GLOBAL MARKET FOR MEMBRANE TECHNOLOGY, 2011 AND 2016 (%) 6

CHAPTER 3 OVERVIEW 9

ABBREVIATIONS USED IN THE MEMBRANE SEPARATION INDUSTRY 9

TABLE 1 ABBREVIATIONS USED IN MEMBRANE SEPARATION INDUSTRY 9

MARKET TRENDS IN THE PHARMACEUTICAL AND BIOPHARMACEUTICAL MARKETS 10

GLOBAL DEMOGRAPHIC TRENDS 10

BIOMANUFACTURING TRENDS 10

Investments in Personalized Medicine 11

PHARMACEUTICAL SECTOR TRENDS 11

TABLE 2 DRUGS THAT LOSE PATENT PROTECTION BETWEEN 2010 AND 2012 11

EXPANSION OF SINGLE-USE TECHNOLOGIES 12

EXPANSION OF INDICATIONS 13

BRIEF HISTORY OF MEMBRANE TECHNOLOGY 13

DEVELOPMENT OF PHARMACEUTICALS 13

PHARMACEUTICALS AND BIOPHARMACEUTICALS 13

Small Molecule Pharmaceuticals 13

Development of Biopharmaceuticals 14

Table 3 BIOLOGIC DRUG DEVELOPMENT VERSUS CONVENTIONAL DRUG DEVELOPMENT 14

DRUG DISCOVERY, DEVELOPMENT, AND MANUFACTURING 14

Drug Discovery 15

FIGURE 1 NEW DRUGS: FROM DISCOVERY TO MANUFACTURING 15

DRUG DEVELOPMENT COSTS 15

RESEARCH FUNDING 16

European Research Funding 16

Biopharmaceutical Pipeline 16

HARMONIZATION 16

GLOBAL DEVELOPMENT OF COMPOUNDS 16

CHAPTER 4 COMPETITION WITHIN THE GLOBAL MEMBRANE INDUSTRY 18

FIGURE 2 MARKET SHARE OF GLOBAL MEMBRANE TECHNOLOGY MANUFACTURERS, 2011

(%) 18

RESEARCH AND DEVELOPMENT SPENDING 18

TABLE 4 GLOBAL R&D SPENDING BY TOP 10 COUNTRIES, 2012 ($ BILLIONS/%) 19

TABLE 5 MAJOR MANUFACTURERS OF MEMBRANE PRODUCTS AND PRODUCT TYPES 19

PURCHASERS OF DISPOSABLE MEMBRANES 20

ECONOMICS OF DISPOSABLE FILTRATION SYSTEMS 20

DISPOSABLE DEMAND AND GOVERNMENT REGULATIONS 21

DISPOSABLE DEMAND AND APPLICATION POTENTIAL 21

CONCERNS REGARDING SUT 21

COMPETITIVE TECHNOLOGIES 21

CHROMATOGRAPHY 22

CENTRIFUGATION 22

Disadvantages of Centrifugation 22

ELECTROPHORESIS 22

MEMBRANE CHROMATOGRAPHY 22

ADVANTAGES/DISADVANTAGES OF MEMBRANE CHROMATOGRAPHY 23

Disadvantages of Membrane Chromatography 23

DIFFERENCES IN SCALING-UP PROCEDURES 24

MARKET SIZES OF MEMBRANE AND COMPETITIVE METHODS 24

FIGURE 3 ESTIMATED GLOBAL MARKET SIZE FOR MEMBRANE CHROMATOGRAPHY AND

COMPETITIVE BIOSEPARATION METHODS IN PHARMACEUTICAL AND

BIOPHARMACEUTICAL PRODUCTION, 2011 (%)

24

ACQUISITIONS IN THE MEMBRANE TECHNOLOGY MARKET 25

TABLE 6 SELECTED ACQUISITIONS WITHIN THE MEMBRANE TECHNOLOGY MARKET,

JANUARY 2005 THROUGH APRIL 2012 ($ MILLIONS) 25

REGIONAL ANALYSIS OF REGULATORY AND REIMBURSEMENT ENVIRONMENTS 26

REGULATORY ENVIRONMENTS 26

The Americas 26

EMRA 26

Asia 27

Japan 27

Australia 27

China 27

India 27

REIMBURSEMENT ENVIRONMENTS 28

The Americas 28

EMRA 28

Asia 28

Japan 28

China 29

India 29

INTRODUCTION OF RAPID MICROBIOLOGICAL METHODS 29

MARKET FOR MEMBRANE TECHNOLOGY, BY GEOGRAPHIC REGION 29

TABLE 7 PROJECTED MARKET FOR MEMBRANE TECHNOLOGY, BY REGION, THROUGH 2016

($ MILLIONS) 29

THE AMERICAS 30

Canadian Pharmaceutical Manufacturing Market 30

South American Pharmaceutical Manufacturing Market 30

Americas Market for Membrane Technology Products 30

Table 8 PROJECTED AMERICAS MARKET FOR MEMBRANE TECHNOLOGY PRODUCTS BY

REGION, THROUGH 2016 ($ MILLIONS) 30

FIGURE 4 AMERICAS MARKET FOR MEMBRANE TECHNOLOGY PRODUCTS, IN 2011 AND

2016 (%) 31

EMRA 32

Western Europe 32

Eastern European 32

Russia 32

Middle East 32

Africa 33

PROJECTED EMRA MEMBRANE TECHNOLOGY MARKET 33

TABLE 9 PROJECTED EMRA MARKET FOR MEMBRANE TECHNOLOGY BY REGION,

THROUGH 2016 ($ MILLIONS) 33

FIGURE 5 EMRA MARKET FOR MEMBRANE TECHNOLOGY PRODUCTS, 2011 AND 2016 (%) 33

ASIA 35

Japan 35

China 35

Australia 35

PROJECTED ASIAN MEMBRANE TECHNOLOGY MARKET 35

TABLE 10 PROJECTED ASIAN MARKET FOR MEMBRANE TECHNOLOGY PRODUCTS BY

REGION, THROUGH 2016 ($ MILLIONS) 35

FIGURE 6 ASIAN MARKET FOR MEMBRANE TECHNOLOGY PRODUCTS, 2011 AND 2016 (%) 36

CHAPTER 5 MEMBRANE MATERIALS AND PROCESSES 39

MEMBRANE MATERIALS 39

TABLE 11 CHARACTERISTICS OF POLYMER MEMBRANE MATERIALS 39

MOLECULAR WEIGHT CUTOFF 40

FLUX 40

FOULING 40

CERAMIC MEMBRANES 40

MODULES 41

MODULE FORMATS 41

Flat Plate Membranes 41

Spiral Wound Membranes 41

Hollow Fiber Membranes 42

Table 12 MODULE MANUFACTURERS/PRODUCTS, 2011 42

CONFIGURATION APPLICATIONS 42

MEMBRANE SEPARATION PROCESSES 43

TABLE 13 FILTERS FOR PHARMACEUTICAL AND BIOPHARMACEUTICAL PROCESSES 43

GLOBAL MARKET FOR MEMBRANE TECHNOLOGY 43

TABLE 14 PROJECTED GLOBAL MARKET FOR MEMBRANES IN PHARMACEUTICAL

PROCESSES, BY TYPE, THROUGH 2016 ($ MILLIONS) 43

REVERSE OSMOSIS 44

PROJECTED GLOBAL MARKET FOR REVERSE OSMOSIS MEMBRANES IN

PHARMACEUTICAL PROCESSES 44

TABLE 15 PROJECTED GLOBAL MARKET FOR REVERSE OSMOSIS MEMBRANES IN

PHARMACEUTICAL PROCESSES, THROUGH 2016 ($ MILLIONS) 44

NANOFILTRATION 44

PROJECTED MARKET FOR NANOFILTRATION MEMBRANES IN PHARMACEUTICAL

PROCESSES 45

TABLE 16 PROJECTED GLOBAL MARKET FOR NANOFILTRATION MEMBRANES IN

PHARMACEUTICAL PROCESSES, THROUGH 2016 ($ MILLIONS) 45

ULTRAFILTRATION 45

PROJECTED GLOBAL MARKET FOR ULTRAFILTRATION MEMBRANES IN

PHARMACEUTICAL PROCESSES 45

TABLE 17 PROJECTED GLOBAL MARKET FOR ULTRAFILTRATION MEMBRANES IN

PHARMACEUTICAL PROCESSES, THROUGH 2016 ($ MILLIONS) 46

MICROFILTRATION 46

PROJECTED GLOBAL MARKET FOR MICROFILTRATION MEMBRANES IN

PHARMACEUTICAL PROCESSES 46

TABLE 18 PROJECTED GLOBAL MARKET FOR MICROFILTRATION MEMBRANES IN

PHARMACEUTICAL PROCESSES, THROUGH 2016 ($ MILLIONS) 47

MICROFILTRATION AND ULTRAFILTRATION IN BIOSEPARATION 47

Ultrafiltration Systems 47

Table 19 BIOPHARMACEUTICAL APPLICATIONS OF UF AND MF 47

ION EXCHANGE MEMBRANES 48

PROJECTED GLOBAL MARKET FOR ION EXCHANGE MEMBRANES IN PHARMACEUTICAL

PROCESSES 48

TABLE 20 PROJECTED GLOBAL MARKET FOR ION EXCHANGE MEMBRANES IN

PHARMACEUTICAL PROCESSES, THROUGH 2016 ($ MILLIONS) 48

METHODS OF FILTRATION 48

PRESSURE-DRIVEN TANGENTIAL FLOW FILTRATION 49

TABLE 21 ACTIONS OF VARIOUS FILTRATION COMPONENTS IN TFF PROCESS 49

TABLE 22 COMPARISON OF SEPARATION METHODS 49

DIRECT-FLOW FILTRATION 50

ELECTRODEIONIZATION 50

CHAPTER 6 MEMBRANE FILTRATION IN PHARMACEUTICAL MANUFACTURING 52

TRENDS IN PHARMACEUTICAL MANUFACTURING 52

R&D IN PHARMACEUTICAL DEVELOPMENT 52

TABLE 23 NUMBER OF DRUGS IN DEVELOPMENT, 2000-2010 52

TABLE 24 R&D EXPENDITURES BY TOP 10 PHARMACEUTICAL COMPANIES BY R&D

SPENDING, 2010 ($ BILLIONS) 53

SHIFTING MARKETPLACE FOR PHARMACEUTICAL MEMBRANE FILTRATION 53

GLOBAL MARKET FOR MEMBRANE FILTRATION IN PHARMACEUTICAL DEVELOPMENT 53

TABLE 25 PROJECTED GLOBAL MARKET FOR MEMBRANE FILTRATION IN THE

PHARMACEUTICAL MARKET, THROUGH 2016 ($ MILLIONS) 54

FIGURE 7 PROJECTED MARKET FOR PHARMACEUTICAL MEMBRANE FILTRATION BY TYPE

OF FILTER, 2011 AND 2016 (%) 54

REGIONAL ANALYSIS OF R&D SPENDING FOR THE DEVELOPMENT OF

PHARMACEUTICAL DRUGS 55

FIGURE 8 MARKET SHARE OF GLOBAL R &D SPENDING, BY REGION, 2012 (%) 55

REGIONAL ANALYSIS OF PHARMACEUTICAL MEMBRANE FILTRATION MARKET 56

TABLE 26 PROJECTED MARKET FOR PHARMACEUTICAL MEMBRANE FILTRATION, BY

REGION, THROUGH 2016 ($ MILLIONS) 56

FIGURE 9 GLOBAL MARKET FOR PHARMACEUTICAL MEMBRANE FILTRATION, BY REGION,

2011 AND 2016 (%) 56

GLOBAL PHARMACEUTICAL MEMBRANE FILTRATION MARKET, BY REGION 58

THE AMERICAS 58

TABLE 27 PROJECTED AMERICAS MARKET FOR PHARMACEUTICAL MEMBRANE

FILTRATION, BY REGION, THROUGH 2016 ($ MILLIONS) 58

FIGURE 10 PROJECTED AMERICAS MARKET FOR PHARMACEUTICAL MEMBRANE

FILTRATION, BY TYPE OF FILTER, 2011 AND 2016 (MILLIONS) 58

EMRA 60

TABLE 28 PROJECTED EMRA MARKET FOR PHARMACEUTICAL MEMBRANE FILTRATION, BY

REGION, THROUGH 2016 ($ MILLIONS) 60

FIGURE 11 PROJECTED EMRA MARKET FOR PHARMACEUTICAL MEMBRANE FILTRATION BY

TYPE OF FILTER, 2011 AND 2016 (MILLIONS) 60

ASIA 62

TABLE 29 PROJECTED ASIAN MARKET FOR PHARMACEUTICAL MEMBRANE FILTRATION, BY

REGION, THROUGH 2016 ($ MILLIONS) 62

FIGURE 12 PROJECTED ASIAN MARKET FOR PHARMACEUTICAL MEMBRANE FILTRATION

BY TYPE OF FILTER, 2011 AND 2016 (MILLIONS) 62

CHAPTER 7 MEMBRANE TECHNOLOGY APPLICATIONS IN LIFE SCIENCES RESEARCH 65

PROJECTED GLOBAL MARKET FOR MEMBRANE TECHNOLOGIES IN THE LIFE SCIENCES 65

TABLE 30 PROJECTED GLOBAL MARKET FOR MEMBRANE TECHNOLOGIES IN LIFE SCIENCE

APPLICATIONS, BY DEVICE/SYSTEM TYPE, THROUGH 2016 ($ MILLIONS) 66

FIGURE 13 GLOBAL MARKET FOR MEMBRANE TECHNOLOGIES IN LIFE SCIENCES

RESEARCH, 2011 AND 2016 (%) 66

MEMBRANE CHROMATOGRAPHY 68

Membrane Adsorbers 68

Hydrophobic-Interaction Membrane Chromatography (HIC) 68

MANUFACTURERS OF MEMBRANE CHROMATOGRAPHY PRODUCTS 69

TABLE 31 MANUFACTURERS/PRODUCTS FOR MEMBRANE CHROMATOGRAPHY, 2011 69

ADVANTAGES OF MEMBRANE CHROMATOGRAPHY TECHNOLOGY IN LARGE-SCALE

BIOMANUFACTURING 69

GLOBAL MARKET FOR MEMBRANE CHROMATOGRAPHY IN BIOPHARMACEUTICAL

APPLICATIONS 70

TABLE 32 PROJECTED GLOBAL MARKET FOR MEMBRANE CHROMATOGRAPHY IN

BIOPHARMACEUTICAL APPLICATIONS, THROUGH 2016 ($ MILLIONS) 70

TRANSFER MEMBRANES 70

Types of Blots 70

Southern Blot 70

Western Blot 71

Colony or Plaque Blots 71

Dot Blots 71

Transfer Membrane Manufacturers/Products 71

Table 33 TRANSFER MEMBRANE MANUFACTURER/PRODUCTS, 2011 71

PROJECTED GLOBAL MARKET FOR TRANSFER MEMBRANES 72

TABLE 34 PROJECTED GLOBAL MARKET FOR TRANSFER MEMBRANE PRODUCTS, THROUGH

2016 ($ MILLIONS) 72

MICROARRAYS 73

PROJECTED GLOBAL MARKET FOR MICROARRAY PRODUCTS 73

TABLE 35 PROJECTED GLOBAL MARKET FOR MICROARRAY PRODUCTS FOR LIFE SCIENCE

APPLICATIONS, THROUGH 2016 ($ MILLIONS) 73

PROTEOMICS AND GENOMICS 73

PROTEOMICS 73

Protein Arrays 74

Protein Array Applications 74

Protein Array Membranes 74

Protein Array Manufacturers/Products 74

Table 36 PROTEIN ARRAY MANUFACTURERS/PRODUCTS, 2011 75

PROJECTED GLOBAL MARKET FOR PROTEIN MICROARRAY PRODUCTS 75

TABLE 37 PROJECTED GLOBAL MARKET FOR PROTEIN MICROARRAY PRODUCTS FOR LIFE

SCIENCE APPLICATIONS, THROUGH 2016 ($ MILLIONS) 76

GENOMICS 76

DNA Macroarrays/Microarrays 76

DNA Microarray Membranes 76

Charging Characteristics of Nylon and NC Membranes 77

DNA Array Manufacturers/Products 77

Table 38 DNA MICROARRAY MANUFACTURERS/PRODUCTS, 2011 77

GLOBAL MARKET FOR DNA MICROARRAY PRODUCTS 78

TABLE 39 PROJECTED GLOBAL MARKET FOR DNA MICROARRAY PRODUCTS FOR LIFE

SCIENCE APPLICATIONS, THROUGH 2016 ($ MILLIONS) 78

DRUG SCREENING 78

THE ODDS AGAINST SUCCESS 78

TOOLS TO ACCESS POTENTIAL PRODUCTS 78

Multiwell Filter Plates 79

ADMET Screening 79

Microwell Plates 79

Solubility Assays 79

Parallel Artificial Membrane Permeation Assays 80

Caco-2 and Other Cell-Based Transport Assays 80

Bound Versus Free Drug Assays 80

Total Drug Analysis 80

DNA Sample Preparation 80

MULTIWELL FILTER PLATE MANUFACTURERS/PRODUCTS 81

TABLE 40 MULTIWELL FILTER PLATE MANUFACTURERS/PRODUCTS, 2011 81

GLOBAL MARKET FOR MULTIWELL FILTER PLATES 84

TABLE 41 PROJECTED GLOBAL MARKET FOR MULTIWELL FILTER PLATES, THROUGH 2016

($ MILLIONS) 84

LAB-SCALE SEPARATIONS 85

GLOBAL MARKET FOR LAB-SCALE MEMBRANE SEPARATION DEVICES 85

TABLE 42 PROJECTED GLOBAL MARKET FOR LAB-SCALE MEMBRANE SEPARATION

DEVICES, THROUGH 2016 ($ MILLIONS) 85

SYRINGE FILTERS 85

Syringeless Filters 86

Syringe /Syringeless Filter Manufacturers/Products 86

Table 43 SYRINGE MEMBRANE FILTER MANUFACTURERS AND PRODUCTS, 2011 86

PROJECTED GLOBAL MARKET FOR SYRINGE FILTERS 87

TABLE 44 PROJECTED GLOBAL MARKET FOR SYRINGE FILTERS, THROUGH 2016 ($

MILLIONS) 87

BOTTLE-TOP FILTERS 87

BOTTLE-TOP FILTER MANUFACTURERS/PRODUCTS 88

TABLE 45 BOTTLE TOP FILTER MANUFACTURERS/PRODUCTS 88

PROJECTED GLOBAL MARKET FOR BOTTLE TOP FILTERS 89

TABLE 46 PROJECTED GLOBAL MARKET FOR BOTTLE TOP FILTERS, THROUGH 2016 ($

MILLIONS) 89

MOLECULAR SEPARATIONS SYSTEMS 89

STIRRED CELL SYSTEMS 89

Stirred Cell Manufacturers/Products 90

Table 47 STIRRED CELL MANUFACTURERS/PRODUCTS 90

CENTRIFUGAL DEVICES 90

Centrifuge Filter Manufacturers/Products 90

Table 48 CENTRIFUGAL FILTER MANUFACTURERS 90

TFF SYSTEMS 91

TFF Replacing Centrifugal, Stirred Cell Systems 91

TFF SYSTEM MANUFACTURERS/PRODUCTS 92

TABLE 49 LAB-SCALE, PILOT-SCALE, SMALL PRODUCTION-SCALE TFF SYSTEMS 92

GLOBAL MARKET FOR MOLECULAR SEPARATION SYSTEMS 93

TABLE 50 PROJECTED GLOBAL MARKET FOR MOLECULAR SEPARATION SYSTEMS,

THROUGH 2016 ($ MILLIONS) 93

LABORATORY WATER SYSTEMS 94

VALIDATING LAB WATER SYSTEMS 94

LAB WATER SYSTEM MANUFACTURERS/PRODUCTS 95

TABLE 51 LABORATORY WATER SYSTEM MANUFACTURERS/PRODUCT 95

PROJECTED MARKET FOR LABORATORY WATER SYSTEMS 95

TABLE 52 PROJECTED GLOBAL MARKET FOR LABORATORY WATER SYSTEMS, THROUGH

2016 ($ MILLIONS) 95

REGIONAL ANALYSIS 96

THE AMERICAS 96

TABLE 53 PROJECTED AMERICAS MARKET FOR MEMBRANE TECHNOLOGY IN THE LIFE

SCIENCES ($ MILLIONS) 96

FIGURE 14 PROJECTED AMERICAS MARKET FOR MEMBRANE TECHNOLOGY IN THE LIFE

SCIENCES, 2011 AND 2016 (%) 96

EMRA 97

PROJECTED MARKET FOR LIFE SCIENCE MEMBRANE TECHNOLOGY IN THE EMRA 98

TABLE 54 PROJECTED EMRA MARKET FOR MEMBRANE TECHNOLOGY IN THE LIFE

SCIENCES, THROUGH 2011 ($ MILLIONS) 98

FIGURE 15 PROJECTED EMRA MARKET FOR MEMBRANE TECHNOLOGY IN THE LIFE

SCIENCES, 2011 AND 2016 (MILLIONS) 98

ASIA 99

PROJECTED ASIAN MARKET FOR MEMBRANE TECHNOLOGY IN THE LIFE SCIENCES 100

TABLE 55 PROJECTED ASIAN MARKET FOR MEMBRANE TECHNOLOGY IN THE LIFE

SCIENCES, THROUGH 2016 ($ MILLIONS) 100

FIGURE 16 PROJECTED ASIAN MARKET FOR MEMBRANE TECHNOLOGY IN THE LIFE

SCIENCES, 2011 AND 2016 (%) 100

CHAPTER 8 BIOPHARMACEUTICAL APPLICATIONS FOR MEMBRANE TECHNOLOGY 103

DEVELOPMENT OF BIOPHARMACEUTICAL APPLICATIONS FOR MEMBRANE

TECHNOLOGY 103

CONSIDERATIONS FOR SCALE-UP 103

BIOPHARMACEUTICAL PRODUCTS 104

TABLE 56 EXAMPLES OF BIOPHARMACEUTICAL PRODUCTS, BY TYPE, PRODUCT,

COMPONENTS, AND APPLICATION 104

GLOBAL MARKET FOR MEMBRANE TECHNOLOGIES IN BIOPHARMACEUTICAL

APPLICATIONS 105

TABLE 57 PROJECTED GLOBAL MARKET FOR MEMBRANE TECHNOLOGIES IN

BIOPHARMACEUTICAL APPLICATIONS, BY PROCESS, THROUGH 2016 ($ MILLIONS) 105

MANUFACTURING PROCESSES 105

FIGURE 17 BIOPHARMACEUTICAL MANUFACTURING PROCESS 105

FIGURE 18 VACCINE MANUFACTURING PROCESS 106

FIGURE 19 VITAMIN, ANTIBIOTIC MANUFACTURING PROCESS 107

MANUFACTURERS USING MEMBRANES IN APPROVED BIOPHARMACEUTICALS 108

TABLE 58 MANUFACTURERS USING MEMBRANES IN APPROVED BIOPHARMACEUTICAL

PRODUCTION 109

BIOMANUFACTURING OBSTACLES 109

EXPANDING CAPACITY 109

PROJECTED MARKET FOR CELL CULTURING SYSTEMS 109

TABLE 59 PROJECTED GLOBAL MARKET FOR CELL CULTURING SYSTEMS, THROUGH 2016

($ MILLIONS) 110

CELL CULTURE SYSTEMS 110

CELL CULTURE INSERTS 110

MEMBRANE INSERT MANUFACTURERS/PRODUCTS 110

TABLE 60 MANUFACTURERS AND PRODUCTS FOR MULTIWELL MEMBRANE INSERTS, 2011 110

CELL CULTURE BIOREACTORS 111

HOLLOW FIBER REACTORS 111

Advantages and Disadvantages of Hollow Fiber Bioreactors 112

CELL CULTURE REACTOR MANUFACTURERS/PRODUCTS 112

TABLE 61 CELL CULTURE REACTOR MANUFACTURERS, 2011 112

DISPOSABLE USE IN CELL CULTURING 113

PROTEIN PURIFICATION MEMBRANES 113

PROJECTED GLOBAL MARKET FOR PROTEIN PURIFICATION WITH MF AND UF 114

TABLE 62 PROJECTED GLOBAL MARKET FOR MICROFILTRATION AND ULTRAFILTRATION

OF PROTEIN SOLUTIONS, THROUGH 2016 ($ MILLIONS) 114

VIRUS FILTERS 115

TABLE 63 VIRAL PURIFICATION MEMBRANE FILTER MANUFACTURERS AND PRODUCTS,

2011 115

PROCESS WATER TREATMENT 115

PROJECTED GLOBAL MARKET FOR PROCESS WATER IN BIOPHARMACEUTICAL

MANUFACTURING 116

TABLE 64 PROJECTED GLOBAL MARKET FOR PROCESS WATER TREATMENTS IN

BIOPHARMACEUTICAL MANUFACTURING, THROUGH 2016 ($ MILLIONS) 116

LARGE-SCALE BIOSEPARATIONS 116

REGIONAL ANALYSIS 116

THE AMERICAS 116

TABLE 65 PROJECTED AMERICAS MARKET FOR MEMBRANE TECHNOLOGY IN

BIOPHARMACEUTICAL APPLICATIONS, THROUGH 2016 ($ MILLIONS) 117

FIGURE 20 PROJECTED AMERICAS MARKET FOR MEMBRANE TECHNOLOGY IN

BIOPHARMACEUTICAL APPLICATIONS, 2011 AND 2016 (%) 117

EMRA 118

TABLE 66 PROJECTED EMRA MARKET FOR MEMBRANE TECHNOLOGY IN

BIOPHARMACEUTICAL APPLICATIONS, THROUGH 2016 ($ MILLIONS) 118

FIGURE 21 PROJECTED EMRA MARKET FOR MEMBRANE TECHNOLOGY IN

BIOPHARMACEUTICAL APPLICATIONS, 2011 AND 2016 (%) 118

ASIA 120

TABLE 67 PROJECTED ASIAN MARKET FOR MEMBRANE TECHNOLOGY IN

BIOPHARMACEUTICAL APPLICATIONS, THROUGH 2016 ($ MILLIONS) 120

FIGURE 22 PROJECTED ASIAN MARKET FOR MEMBRANE TECHNOLOGY IN

BIOPHARMACEUTICAL APPLICATIONS, 2011 AND 2016 (%) 120

CHAPTER 9 EMERGING TECHNOLOGIES AND PATENTS 123

EMERGING TECHNOLOGIES 123

DISPOSABLE MEMBRANE ADSORBERS 123

SALT TOLERANT INTERACTION CHROMATOGRAPHY (STIC) 123

BIOREACTOR BAGS 123

AUTOMATICALLY CONTROLLED FEEDING PROCESS FOR RECOMBINANT PROTEIN

PRODUCTION 124

PATENTS 124

PATENTS, BY COMPANY, 2008 TO 2011 124

TABLE 68 ISSUED PATENTS, BY COMPANY AND NUMBER OF PATENTS, 2008-2011

(NUMBER/%) 125

FIGURE 23 ISSUED PATENTS, BY COMPANY, 2008-2012 (%) 125

PATENTS ISSUED FOR MEMBRANE TECHNOLOGIES, FROM 2008 THROUGH 2012,

BY YEAR 126

TABLE 69 PATENTS ISSUED BETWEEN 2008 AND 2012 BY DATE, PATENT NUMBER,

COMPANY, AND DESCRIPTION OF THE PRODUCT OR PROCESS 126

PATENTS LISTED BY NUMBER 128

TABLE 70 PATENTS ISSUED BETWEEN 2008 AND 2012, BY PATENT NUMBER AND COMPANY 128

PATENT LISTED BY NUMBER AND DESCRIPTION 129

TABLE 71 PATENTS ISSUED BETWEEN 2008 AND 2012 BY DESCRIPTION AND PATENT

NUMBER 129

CHAPTER 10 COMPANY DIRECTORY 131

20/20 GENE SYSTEMS 131

3M HEALTHCARE, MEDICAL DIVISION 131

ADVANTEC MFS, INC. 131

AMGEN 132

AMAZON FILTERS LTD. 132

APPLIKON BIOTECHNOLOGY B.V. 132

ASAHI KASEI CORPORATION 133

ATMI LIFE SCIENCES 133

BECTON DICKINSON BIOSCIENCES 133

BIOVEST INTERNATIONAL 134

CLONTECH/TAKARA BIO, INC. 134

CORNING LIFESCIENCES 134

CUNO, INC. 135

EMD MILLIPORE 135

FIBERCELL SYSTEMS, INC 135

GEN-PROBE, INC. 136

GE HEALTHCARE BIOSCIENCES AB (U.S. OFFICE) 136

GE OSMONICS 136

HIKMA PHARMACEUTICALS PLC 136

INTAS BIOPHARMACEUTICALS 137

BUSINESS OVERVIEW 137

KOCH MEMBRANE SYSTEMS 137

LIFE TECHNOLOGIES 137

MACHEREY-NAGEL GMBH 138

MECO BIOPHARMACEUTICALS 138

MEISSNER FILTRATION PRODUCTS 138

NOVASEP 139

PALL CORP. 139

PANACEA BIOTEC, LTD (INDIA) 140

PBS BIOTECH 140

PROMETIC LIFESCIENCES 140

PROMEGA 141

QIAGEN NV 141

ROCHE DIAGNOSTICS 141

SARTORIUS CORP. 142

BUSINESS OVERVIEW 142

SIEMENS CORPORATION (WATER TECHNOLOGIES) 142

SIGMA ALDRICH CORPORATION 142

SPECTRUM LABORATORIES 143

STERLITECH CORPORATION 143

SYNDER FILTRATION 143

SYNKERA TECHNOLOGIES, INC. 143

SYNTHECON, INC. 144

TAMI INDUSTRIES 144

TRISEP CORP. 145

US. FILTER/SIEMENS WATER TECHNOLOGIES 145

WHATMAN PLC 145

XCELLEREX 145

LIST OF TABLES

SUMMARY TABLE GLOBAL MARKET FOR MEMBRANE TECHNOLOGY, THROUGH 2016 ($MILLIONS) 6TABLE 1 ABBREVIATIONS USED IN MEMBRANE SEPARATION INDUSTRY 9TABLE 2 DRUGS THAT LOSE PATENT PROTECTION BETWEEN 2010 AND 2012 11TABLE 3 BIOLOGIC DRUG DEVELOPMENT VERSUS CONVENTIONAL DRUG DEVELOPMENT 14TABLE 4 GLOBAL R&D SPENDING BY TOP 10 COUNTRIES, 2012 ($ BILLIONS/%) 19TABLE 5 MAJOR MANUFACTURERS OF MEMBRANE PRODUCTS AND PRODUCT TYPES 19TABLE 6 SELECTED ACQUISITIONS WITHIN THE MEMBRANE TECHNOLOGY MARKET,JANUARY 2005 THROUGH APRIL 2012 ($ MILLIONS) 25TABLE 7 PROJECTED MARKET FOR MEMBRANE TECHNOLOGY, BY REGION, THROUGH 2016($ MILLIONS) 29TABLE 8 PROJECTED AMERICAS MARKET FOR MEMBRANE TECHNOLOGY PRODUCTS BYREGION, THROUGH 2016 ($ MILLIONS) 30TABLE 9 PROJECTED EMRA MARKET FOR MEMBRANE TECHNOLOGY BY REGION, THROUGH2016 ($ MILLIONS) 33TABLE 10 PROJECTED ASIAN MARKET FOR MEMBRANE TECHNOLOGY PRODUCTS BYREGION, THROUGH 2016 ($ MILLIONS) 35TABLE 11 CHARACTERISTICS OF POLYMER MEMBRANE MATERIALS 39TABLE 12 MODULE MANUFACTURERS/PRODUCTS, 2011 42TABLE 13 FILTERS FOR PHARMACEUTICAL AND BIOPHARMACEUTICAL PROCESSES 43TABLE 14 PROJECTED GLOBAL MARKET FOR MEMBRANES IN PHARMACEUTICALPROCESSES, BY TYPE, THROUGH 2016 ($ MILLIONS) 43TABLE 15 PROJECTED GLOBAL MARKET FOR REVERSE OSMOSIS MEMBRANES INPHARMACEUTICAL PROCESSES, THROUGH 2016 ($ MILLIONS) 44TABLE 16 PROJECTED GLOBAL MARKET FOR NANOFILTRATION MEMBRANES INPHARMACEUTICAL PROCESSES, THROUGH 2016 ($ MILLIONS) 45TABLE 17 PROJECTED GLOBAL MARKET FOR ULTRAFILTRATION MEMBRANES INPHARMACEUTICAL PROCESSES, THROUGH 2016 ($ MILLIONS) 46TABLE 18 PROJECTED GLOBAL MARKET FOR MICROFILTRATION MEMBRANES INPHARMACEUTICAL PROCESSES, THROUGH 2016 ($ MILLIONS) 47TABLE 19 BIOPHARMACEUTICAL APPLICATIONS OF UF AND MF 47TABLE 20 PROJECTED GLOBAL MARKET FOR ION EXCHANGE MEMBRANES INPHARMACEUTICAL PROCESSES, THROUGH 2016 ($ MILLIONS) 48TABLE 21 ACTIONS OF VARIOUS FILTRATION COMPONENTS IN TFF PROCESS 49TABLE 22 COMPARISON OF SEPARATION METHODS 49TABLE 23 NUMBER OF DRUGS IN DEVELOPMENT, 2000-2010 52TABLE 24 R&D EXPENDITURES BY TOP 10 PHARMACEUTICAL COMPANIES BY R&DSPENDING, 2010 ($ BILLIONS) 53TABLE 25 PROJECTED GLOBAL MARKET FOR MEMBRANE FILTRATION IN THEPHARMACEUTICAL MARKET, THROUGH 2016 ($ MILLIONS) 54TABLE 26 PROJECTED MARKET FOR PHARMACEUTICAL MEMBRANE FILTRATION, BYREGION, THROUGH 2016 ($ MILLIONS) 56TABLE 27 PROJECTED AMERICAS MARKET FOR PHARMACEUTICAL MEMBRANE FILTRATION,BY REGION, THROUGH 2016 ($ MILLIONS) 58TABLE 28 PROJECTED EMRA MARKET FOR PHARMACEUTICAL MEMBRANE FILTRATION, BYREGION, THROUGH 2016 ($ MILLIONS) 60TABLE 29 PROJECTED ASIAN MARKET FOR PHARMACEUTICAL MEMBRANE FILTRATION, BYREGION, THROUGH 2016 ($ MILLIONS) 62TABLE 30 PROJECTED GLOBAL MARKET FOR MEMBRANE TECHNOLOGIES IN LIFE SCIENCEAPPLICATIONS, BY DEVICE/SYSTEM TYPE, THROUGH 2016 ($ MILLIONS) 66TABLE 31 MANUFACTURERS/PRODUCTS FOR MEMBRANE CHROMATOGRAPHY, 2011 69TABLE 32 PROJECTED GLOBAL MARKET FOR MEMBRANE CHROMATOGRAPHY INBIOPHARMACEUTICAL APPLICATIONS, THROUGH 2016 ($ MILLIONS) 70TABLE 33 TRANSFER MEMBRANE MANUFACTURER/PRODUCTS, 2011 71TABLE 34 PROJECTED GLOBAL MARKET FOR TRANSFER MEMBRANE PRODUCTS, THROUGH2016 ($ MILLIONS) 72TABLE 35 PROJECTED GLOBAL MARKET FOR MICROARRAY PRODUCTS FOR LIFE SCIENCEAPPLICATIONS, THROUGH 2016 ($ MILLIONS) 73TABLE 36 PROTEIN ARRAY MANUFACTURERS/PRODUCTS, 2011 75TABLE 37 PROJECTED GLOBAL MARKET FOR PROTEIN MICROARRAY PRODUCTS FOR LIFESCIENCE APPLICATIONS, THROUGH 2016 ($ MILLIONS) 76TABLE 38 DNA MICROARRAY MANUFACTURERS/PRODUCTS, 2011 77TABLE 39 PROJECTED GLOBAL MARKET FOR DNA MICROARRAY PRODUCTS FOR LIFESCIENCE APPLICATIONS, THROUGH 2016 ($ MILLIONS) 78TABLE 40 MULTIWELL FILTER PLATE MANUFACTURERS/PRODUCTS, 2011 81TABLE 41 PROJECTED GLOBAL MARKET FOR MULTIWELL FILTER PLATES, THROUGH 2016 ($MILLIONS) 84TABLE 42 PROJECTED GLOBAL MARKET FOR LAB-SCALE MEMBRANE SEPARATION DEVICES,THROUGH 2016 ($ MILLIONS) 85TABLE 43 SYRINGE MEMBRANE FILTER MANUFACTURERS AND PRODUCTS, 2011 86TABLE 44 PROJECTED GLOBAL MARKET FOR SYRINGE FILTERS, THROUGH 2016 ($ MILLIONS) 87TABLE 45 BOTTLE TOP FILTER MANUFACTURERS/PRODUCTS 88TABLE 46 PROJECTED GLOBAL MARKET FOR BOTTLE TOP FILTERS, THROUGH 2016 ($MILLIONS) 89TABLE 47 STIRRED CELL MANUFACTURERS/PRODUCTS 90TABLE 48 CENTRIFUGAL FILTER MANUFACTURERS 90TABLE 49 LAB-SCALE, PILOT-SCALE, SMALL PRODUCTION-SCALE TFF SYSTEMS 92TABLE 50 PROJECTED GLOBAL MARKET FOR MOLECULAR SEPARATION SYSTEMS, THROUGH2016 ($ MILLIONS) 93TABLE 51 LABORATORY WATER SYSTEM MANUFACTURERS/PRODUCT 95TABLE 52 PROJECTED GLOBAL MARKET FOR LABORATORY WATER SYSTEMS, THROUGH 2016($ MILLIONS) 95TABLE 53 PROJECTED AMERICAS MARKET FOR MEMBRANE TECHNOLOGY IN THE LIFESCIENCES ($ MILLIONS) 96TABLE 54 PROJECTED EMRA MARKET FOR MEMBRANE TECHNOLOGY IN THE LIFESCIENCES, THROUGH 2011 ($ MILLIONS) 98TABLE 55 PROJECTED ASIAN MARKET FOR MEMBRANE TECHNOLOGY IN THE LIFESCIENCES, THROUGH 2016 ($ MILLIONS) 100TABLE 56 EXAMPLES OF BIOPHARMACEUTICAL PRODUCTS, BY TYPE, PRODUCT,COMPONENTS, AND APPLICATION 104TABLE 57 PROJECTED GLOBAL MARKET FOR MEMBRANE TECHNOLOGIES INBIOPHARMACEUTICAL APPLICATIONS, BY PROCESS, THROUGH 2016 ($ MILLIONS) 105TABLE 58 MANUFACTURERS USING MEMBRANES IN APPROVED BIOPHARMACEUTICALPRODUCTION 109TABLE 59 PROJECTED GLOBAL MARKET FOR CELL CULTURING SYSTEMS, THROUGH 2016 ($MILLIONS) 110TABLE 60 MANUFACTURERS AND PRODUCTS FOR MULTIWELL MEMBRANE INSERTS, 2011 110TABLE 61 CELL CULTURE REACTOR MANUFACTURERS, 2011 112TABLE 62 PROJECTED GLOBAL MARKET FOR MICROFILTRATION AND ULTRAFILTRATION OFPROTEIN SOLUTIONS, THROUGH 2016 ($ MILLIONS) 114TABLE 63 VIRAL PURIFICATION MEMBRANE FILTER MANUFACTURERS AND PRODUCTS,2011 115TABLE 64 PROJECTED GLOBAL MARKET FOR PROCESS WATER TREATMENTS INBIOPHARMACEUTICAL MANUFACTURING, THROUGH 2016 ($ MILLIONS) 116TABLE 65 PROJECTED AMERICAS MARKET FOR MEMBRANE TECHNOLOGY INBIOPHARMACEUTICAL APPLICATIONS, THROUGH 2016 ($ MILLIONS) 117TABLE 66 PROJECTED EMRA MARKET FOR MEMBRANE TECHNOLOGY INBIOPHARMACEUTICAL APPLICATIONS, THROUGH 2016 ($ MILLIONS) 118TABLE 67 PROJECTED ASIAN MARKET FOR MEMBRANE TECHNOLOGY INBIOPHARMACEUTICAL APPLICATIONS, THROUGH 2016 ($ MILLIONS) 120TABLE 68 ISSUED PATENTS, BY COMPANY AND NUMBER OF PATENTS, 2008-2011(NUMBER/%) 125TABLE 69 PATENTS ISSUED BETWEEN 2008 AND 2012 BY DATE, PATENT NUMBER,COMPANY, AND DESCRIPTION OF THE PRODUCT OR PROCESS 126TABLE 70 PATENTS ISSUED BETWEEN 2008 AND 2012, BY PATENT NUMBER AND COMPANY 128TABLE 71 PATENTS ISSUED BETWEEN 2008 AND 2012 BY DESCRIPTION AND PATENTNUMBER 129

LIST OF FIGURES

SUMMARY FIGURE GLOBAL MARKET FOR MEMBRANE TECHNOLOGY, 2011 AND 2016 (%) 6

FIGURE 1 NEW DRUGS: FROM DISCOVERY TO MANUFACTURING 15

FIGURE 2 MARKET SHARE OF GLOBAL MEMBRANE TECHNOLOGY MANUFACTURERS, 2011

(%) 18

FIGURE 3 ESTIMATED GLOBAL MARKET SIZE FOR MEMBRANE CHROMATOGRAPHY AND

COMPETITIVE BIOSEPARATION METHODS IN PHARMACEUTICAL AND BIOPHARMACEUTICAL

PRODUCTION, 2011 (%)

24

FIGURE 4 AMERICAS MARKET FOR MEMBRANE TECHNOLOGY PRODUCTS, IN 2011 AND 2016

(%) 31

FIGURE 5 EMRA MARKET FOR MEMBRANE TECHNOLOGY PRODUCTS, 2011 AND 2016 (%) 33

FIGURE 6 ASIAN MARKET FOR MEMBRANE TECHNOLOGY PRODUCTS, 2011 AND 2016 (%) 36

FIGURE 7 PROJECTED MARKET FOR PHARMACEUTICAL MEMBRANE FILTRATION BY TYPE OF

FILTER, 2011 AND 2016 (%) 54

FIGURE 8 MARKET SHARE OF GLOBAL R &D SPENDING, BY REGION, 2012 (%) 55

FIGURE 9 GLOBAL MARKET FOR PHARMACEUTICAL MEMBRANE FILTRATION, BY REGION,

2011 AND 2016 (%) 56

FIGURE 10 PROJECTED AMERICAS MARKET FOR PHARMACEUTICAL MEMBRANE

FILTRATION, BY TYPE OF FILTER, 2011 AND 2016 (MILLIONS) 58

FIGURE 11 PROJECTED EMRA MARKET FOR PHARMACEUTICAL MEMBRANE FILTRATION BY

TYPE OF FILTER, 2011 AND 2016 (MILLIONS) 60

FIGURE 12 PROJECTED ASIAN MARKET FOR PHARMACEUTICAL MEMBRANE FILTRATION BY

TYPE OF FILTER, 2011 AND 2016 (MILLIONS) 62

FIGURE 13 GLOBAL MARKET FOR MEMBRANE TECHNOLOGIES IN LIFE SCIENCES

RESEARCH, 2011 AND 2016 (%) 66

FIGURE 14 PROJECTED AMERICAS MARKET FOR MEMBRANE TECHNOLOGY IN THE LIFE

SCIENCES, 2011 AND 2016 (%) 96

FIGURE 15 PROJECTED EMRA MARKET FOR MEMBRANE TECHNOLOGY IN THE LIFE

SCIENCES, 2011 AND 2016 (MILLIONS) 98

FIGURE 16 PROJECTED ASIAN MARKET FOR MEMBRANE TECHNOLOGY IN THE LIFE

SCIENCES, 2011 AND 2016 (%) 100

FIGURE 17 BIOPHARMACEUTICAL MANUFACTURING PROCESS 105

FIGURE 18 VACCINE MANUFACTURING PROCESS 106

FIGURE 19 VITAMIN, ANTIBIOTIC MANUFACTURING PROCESS 107

FIGURE 20 PROJECTED AMERICAS MARKET FOR MEMBRANE TECHNOLOGY IN

BIOPHARMACEUTICAL APPLICATIONS, 2011 AND 2016 (%) 117

FIGURE 21 PROJECTED EMRA MARKET FOR MEMBRANE TECHNOLOGY IN

BIOPHARMACEUTICAL APPLICATIONS, 2011 AND 2016 (%) 118

FIGURE 22 PROJECTED ASIAN MARKET FOR MEMBRANE TECHNOLOGY IN

BIOPHARMACEUTICAL APPLICATIONS, 2011 AND 2016 (%) 120

FIGURE 23 ISSUED PATENTS, BY COMPANY, 2008-2012 (%) 125

To order this report:Biopharmaceutical Industry: Global Markets for Membrane Technology for Pharmaceuticals

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