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Global Hormone Replacement Therapy (HRT) Industry
Date:11/7/2011

NEW YORK, Nov. 7, 2011 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Global Hormone Replacement Therapy (HRT) Industry

http://www.reportlinker.com/p0681889/Global-Hormone-Replacement-Therapy-HRT-Industry.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biologica

This report analyzes the worldwide markets for Hormone Replacement Therapy (HRT) in US$ Million. The report provides separate comprehensive analytics for the US, Canada, Europe, Asia-Pacific, and Rest of World. Annual estimates and forecasts are provided for the period 2009 through 2017. A six-year historic analysis is also provided for these markets. The report profiles 42 companies including many key and niche players such as Bayer HealthCare Pharmaceuticals, Inc., Besins Healthcare SA, Hisamitsu Pharmaceutical Co., Inc., Noven Pharmaceuticals, Inc., Mylan Canada, Novartis AG, Novo Nordisk A/S, Orion Corporation, Pfizer, Inc., Wyeth Pharmaceuticals, Inc., Rottapharm SpA, Teva Pharmaceutical Industries Ltd., Theramex, Warner Chilcott, and Watson Pharmaceuticals, Inc. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

1. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS 1

Study Reliability and Reporting Limitations 1

Disclaimers 2

Data Interpretation & Reporting Level 3

Quantitative Techniques & Analytics 3

Product Definition and Scope of Study 3

2. INDUSTRY OVERVIEW 5

WHI Study- A Major Blow to the HRT Market 5

An Overview 6

Milestones and Downfalls in the Hormone Replacement Therapy

Market 7

Current and Future Analysis 7

Wyeth's Premarin Family Tops the List in terms of Number of

New HRT Prescriptions Dispensed 8

Table 1: Hormone Replacement Therapy (HRT) Market by Major

Brands (HRT/ERT): Market Share Breakdown of New

Prescriptions for Premarin, PremPro, and Others (includes

corresponding Graph/Chart) 8

3. MARKET TRENDS 9

Standard Oral Doses Continue to Dominate Over Relatively Safer

Low Dose and Transdermal Alternatives 9

HRT for Menopause Symptoms: A Highly Underserved Market 9

Table 2: Decline in HRT Prescriptions (2001-2009) (includes

corresponding Graph/Chart) 10

Safety Issues: A Major Deterrent to the HRT Market 10

Market Size Restricted by Lesser Number of Women Opting for

Treatments 10

Market to Stabilize with Sales of Transdermal HRT Making up

for Decline in Oral HRT Sales 11

Growth Remains Sluggish, New Products Slated for Release

Likely to Drive the HRT Market 11

Transdermal Products Facilitating Localized Absorption: Need

of the Hour 11

Non-Hormonal Products to Gain Focus as Market Continues to

Decline with Hormonal Products still Facing Safety Issues 12

Promising Non-Hormonal Drug/Product Pipeline to Augur Well for

HRT Market 13

Select Non-Hormonal Products Under Development 13

HRT Market to Witness Positive Growth as New Promising Drugs/

Products Set for Release Post 2011 13

Select Hormonal Drug/Product Pipeline by Company 14

Select Non-Hormonal Drug/Product Pipeline by Company 14

Menerba: A Promising Non-Hormone Therapy for Menopausal Hot

Flashes 14

Seala®: Bionovo's Pipeline Product for Vaginal Dryness 15

Serada (Extended Release Tablets): A Promising Non-HRT Drug

for Hot Flash 15

Mesafem™ for Vasomotor Symptoms 15

Select Hormone Therapies for the Treatment of Postmenopausal

Symptoms by Manufacturer 15

Select Hormone Therapies for the Treatment of Postmenopausal

Symptoms by Manufacturer 16

Select Hormone Therapies for Post Menopausal Women by Year of

Patent Expiry 16

Select Hormone Therapies for Treatment of Postmenopausal

Symptoms by Generic Manufacturers 17

4. PRODUCT OVERVIEW 18

What are Hormones? 18

What is Menopause? 19

Menopause Symptoms and Complaints 19

What is Hormone Replacement Therapy? 19

Why HRT? 20

FDA-Approved Hormones 21

Estrogen 21

Progestins 21

Contraindications of HRT 21

Hormones Currently under the FDA's Consideration 21

Testosterone 21

Dehydroepiandrosterone (DHEA) 22

Historical Progression 22

Advantages and Disadvantages of Using HRT 22

Benefits of Hormone Therapy 23

Relief from Vasomotor Symptoms 23

Vaginal Symptoms 23

Improvement in Sexual Functioning 23

Urinary Health 23

Management of Variations in Body Weight/ Mass 23

Ensuring Quality of Life 24

Osteoporosis 24

Diabetes Mellitus (DM) 24

Impact on Overall Mortality 24

Risks Involved in Hormone Therapy 24

Hormone Therapies in HRT and their Effect 25

Potential Benefits and Risks of HRT in Menopausal Symptoms 26

Common and Less Common Side Effects of Using Estrogen-alone,

Progesterone-alone or Combination Therapies 26

Potential Issues 26

Cardiovascular Problems 26

Coronary Heart Disease (CHD) 26

Stroke 27

Venous Thromboembolism (VTE) 27

Endometrial Cancer 27

Breast Cancer 27

Estrogen-Progestogen Therapy 27

Estrogen Therapy 27

Lung Cancer 28

Depression and Mood Swings 28

Ovarian Cancer 28

Routes of Administration 28

Systemic Treatment 28

Pills 28

Vaginal Estrogen Ring 28

Transdermal Estrogen Skin Patches 28

Localized Treatment 29

Vaginal Estrogen Tablets 29

Estrogen Creams 29

Intrauterine Progestin System (IUS) 29

Lower Dose Vaginal Estrogen Ring 29

Vaginal Progesterone Gel 29

Bioidentical Hormone Replacement Therapy (BHRT) 30

Divigel: A BHRT 30

Historical Background 31

More Claims than Evidence 31

Regulatory Scenario in the US 32

Other Alternatives 32

Prescription Medication 32

Gabapentin 33

Clonidine 33

SNRIs and SSRIs 33

Botanicals 33

Black Cohosh 33

Phytoestrogens (Isoflavones) 33

Other Botanical Products 33

Non-botanical Supplements 34

Mind/Body therapies 34

Exercise and Diet 34

5. RECENT INDUSTRY ACTIVITY 35

BioNovo to Conduct Phase III Clinical Trials for Menerba 35

Novo Nordisk Unveils Vagifem® 10µg 35

Pfizer Global Manufacturing to Reconfigure Global Plant Network 36

Amgen Obtains FDA Approval for Prolia in Treating

Postmenopausal Women at Greater Risk of Osteoporosis 36

Watson Enters into Agreement to Acquire US rights of CLI's

Bioadhesive Progesterone Gel 36

Solvay Divests Pharmaceutical Business 37

NaturalNectar Introduces EaseFemin Menopausal Support 37

Hisamitsu Pharmaceutical Acquires Noven Pharmaceuticals 37

Wyeth Receives FDA Approval for Premarin Vaginal Cream 0.5 gm 38

Wyeth Conducts Phase III SMART-1 Clinical Trial for

Bazedoxifene/Conjugated Estrogens 38

The Competition Bureau Enters Into Agreement with Pfizer and

Wyeth for Resolving Competition Concerns 38

BodyLogicMD Introduces Updated Website 39

Bayer Launches Angeliq® in Canada 39

ASKA Receives Approval for Menoaid Combipatch 39

Depomed Initiates Gabapentin GR Phase III Trials 39

Dutch Authority Accepts Clinical Trial Application for Radius

Health's RAD1901 40

US FDA Approves Duramed's SCE-A Vaginal Cream 40

6. FOCUS ON SELECT KEY PLAYERS 41

Bayer HealthCare Pharmaceuticals, Inc. (US) 41

Besins Healthcare SA (Belgium) 41

Hisamitsu Pharmaceutical Co., Inc. 41

Noven Pharmaceuticals, Inc. (US) 42

Noven: Select HRT Drugs/Products Marketed in the US and Abroad 42

Mylan 43

Mylan Canada (Canada) 43

Novartis AG (Switzerland) 43

Novo Nordisk A/S (Denmark) 44

Table 3: Novo-Nordisk (2008-2010): Worldwide Annual Sales for

HRT Drugs/Products (In DKKm) (includes corresponding

Graph/Chart) 44

Orion Corporation (Finland) 44

Pfizer, Inc. (US) 45

Wyeth Pharmaceuticals, Inc. 45

Table 4: Wyeth: Select HRT Drug/Product Sales in the US

(2009) (In US$ Million) (includes corresponding Graph/Chart) 46

Rottapharm SpA (Italy) 46

Teva Pharmaceutical Industries Ltd. (Israel) 46

Theramex (France) 47

Warner Chilcott (US) 47

Table 5: Warner Chilcott (2008-2010): Global Sales of HRTs in

US$ Million (includes corresponding Graph/Chart) 48

Watson Pharmaceuticals, Inc. (US) 48

7. GLOBAL MARKET PERSPECTIVE 49

Table 6: World Recent Past, Current & Future Analysis for

Hormone Replacement Therapy (HRT) Market by Geographic Region

- US, Canada, Europe, Asia-Pacific, and Rest of World

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2009 through 2017 (includes corresponding

Graph/Chart) 49

Table 7: World Historic Review for Hormone Replacement Therapy

(HRT) Market by Geographic Region US, Canada, Europe,

Asia-Pacific, and Rest of World Independently Analyzed with

Annual Sales Figures in US$ Million for Years 2003 through

2008 (includes corresponding Graph/Chart) 50

Table 8: World 15-Year Perspective for Hormone Replacement

Therapy (HRT) Market by Geographic Region - Percentage

Breakdown of Dollar Sales for US, Canada, Europe,

Asia-Pacific, and Rest of World for Years 2003, 2010 & 2017

(includes corresponding Graph/Chart) 51

8. THE UNITED STATES 52

A.Market Analysis 52

The US Prescriptions of Menopause Hormone Therapy Witnessing

a Downtrend 52

Oral Premarin: Favored Estrogen Therapy in the US 52

Prempro: Most Dispensed Estrogen-Progestogen Combination in

the US 52

Baby Boomers Offering Exciting Market Opportunity to HRT Makers 52

Bioidentical HRT Witnessing Growing Popularity in the US 53

Bioidentical Hormones Approved by FDA (As of 2008) 53

BHRT Makers under US FDA-Scanner for Using Dubious Marketing

Techniques 54

Alternatives to HRT 54

Currently Available Off-label Drugs for Treatment of

Menopausal Symptoms 54

Cost of Hormone Replacement Therapy 55

Table 9: Cost of Estrogen-Only Pills (2008) 55

Table 10: Cost of Estrogen-only Skin Patches (2008) 55

Table 11: Cost of Estrogen-only Skin Creams and Sprays

(2008) 56

Table 12: Cost of Estrogen plus Progesterone Pills (2008) 56

Table 13: Cost of Estrogen plus Progesterone Skin Patches

(2008) 56

Table 14: Cost of Estrogen-only Vaginal Creams, Tablets or

Rings (2008) 56

Mylan's Generic Version of Climara Out in the Market 56

Oral Estrogen Therapy Products for Treating Menopausal

Symptoms 57

Transdermal and Topical Estrogen Therapy Products for

Treating Menopausal Symptoms 57

Vaginal Estrogen Therapy Products for Treating Menopausal

Symptoms 58

Combination Estrogen Therapy Products for Treating

Menopausal Symptoms 58

Select Combination Estrogen Therapy Products for Treating

Menopausal Symptoms 58

Progestogens in EPT 59

Strategic Corporate Developments 59

Focus on Select Key Players 63

Bayer HealthCare Pharmaceuticals, Inc. (US) 63

Pfizer, Inc. (US) 63

Wyeth Pharmaceuticals, Inc. 64

Table 15: Wyeth: Select HRT Drug/Product Sales in the US

(2009) (In US$ Million) (includes corresponding

Graph/Chart) 64

Table 16: Hormone Replacement Therapy/ Estrogen

Replacement Therapy (HRT/ERT): Decline in

Oral/Transdermal-Prescriptions (in Million) (includes

corresponding Graph/Chart) 65

Warner Chilcott (US) 65

Table 17: Warner Chilcott (2008-2010): Sales of HRTs in

US$ Million (includes corresponding Graph/Chart) 65

Watson Pharmaceuticals, Inc. (US) 66

B.Market Analytics 66

Table 18: The US Recent Past, Current & Future Analysis for

Hormone Replacement Therapy (HRT) Market Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2009 through 2017 (includes corresponding Graph/Chart) 66

Table 19: The US Historic Review for Hormone Replacement

Therapy (HRT) Market Independently Analyzed with Annual

Sales Figures in US$ Million for Years 2003 through 2008

(includes corresponding Graph/Chart) 67

9. CANADA 68

A.Market Analysis 68

Oral Estrogen Therapy Products for Treating Menopausal Symptoms 68

Transdermal and Topical Estrogen Therapy Products for

Treating Menopausal Symptoms (Canada) 69

Vaginal Estrogen Therapy Products for Treating Menopausal

Symptoms 69

Combination Estrogen Therapy Products for Treating

Menopausal Symptoms 69

Progestogens used for EPT in the Treatment of Menopausal

Symptoms 70

Strategic Corporate Development 70

Bayer Launches Angeliq® in Canada 70

B.Market Analytics 71

Table 20: Canadian Recent Past, Current & Future Analysis

for Hormone Replacement Therapy (HRT) Market Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2009 through 2017 (includes corresponding Graph/Chart) 71

Table 21: Canadian Historic Review for Hormone Replacement

Therapy (HRT) Market Independently Analyzed with Annual

Sales Figures in US$ Million for Years 2003 through 2008

(includes corresponding Graph/Chart) 72

10. EUROPE 73

Market Analysis 73

Table 22: European Recent Past, Current & Future Analysis

for Hormone Replacement Therapy (HRT) Market by Geographic

Region - France, Germany, Italy, UK, and Rest of Europe

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2009 through 2017 (includes corresponding

Graph/Chart) 73

Table 23: European Historic Review for Hormone Replacement

Therapy (HRT) Market by Geographic Region - France, Germany,

Italy, UK, and Rest of Europe Independently Analyzed with

Annual Sales Figures in US$ Million for Years 2003 through

2008 (includes corresponding Graph/Chart) 74

Table 24: European 15-Year Perspective for Hormone

Replacement Therapy (HRT) Market by Geographic Region -

Percentage Breakdown of Dollar Sales for - France, Germany,

Italy, UK, and Rest of Europe for Years 2003, 2010 & 2017

(includes corresponding Graph/Chart) 75

10a. FRANCE 76

Market Analysis 76

Table 25: French Recent Past, Current & Future Analysis for

Hormone Replacement Therapy (HRT) Market Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2009 through 2017 (includes corresponding Graph/Chart) 76

Table 26: French Historic Review for Hormone Replacement

Therapy (HRT) Market Independently Analyzed with Annual

Sales Figures in US$ Million for Years 2003 through 2008

(includes corresponding Graph/Chart) 77

10b. GERMANY 78

Market Analysis 78

Table 27: German Recent Past, Current & Future Analysis for

Hormone Replacement Therapy (HRT) Market Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2009 through 2017 (includes corresponding Graph/Chart) 78

Table 28: German Historic Review for Hormone Replacement

Therapy (HRT) Market Independently Analyzed with Annual

Sales Figures in US$ Million for Years 2003 through 2008

(includes corresponding Graph/Chart) 79

10c. ITALY 80

A.Market Analysis 80

Rottapharm SpA: A Key Player 80

B.Market Analytics 81

Table 29: Italian Recent Past, Current & Future Analysis for

Hormone Replacement Therapy (HRT) Market Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2009 through 2017 (includes corresponding Graph/Chart) 81

Table 30: Italian Historic Review for Hormone Replacement

Therapy (HRT) Market Independently Analyzed with Annual

Sales Figures in US$ Million for Years 2003 through 2008

(includes corresponding Graph/Chart) 82

10d. THE UNITED KINGDOM 83

Market Analysis 83

Table 31: The UK Recent Past, Current & Future Analysis for

Hormone Replacement Therapy (HRT) Market Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2009 through 2017 (includes corresponding Graph/Chart) 83

Table 32: The UK Historic Review for Hormone Replacement

Therapy (HRT) Market Independently Analyzed with Annual

Sales Figures in US$ Million for Years 2003 through 2008

(includes corresponding Graph/Chart) 84

10e. REST OF EUROPE 85

A.Market Analysis 85

Strategic Corporate Development 85

Focus on Select Key Players 86

Novartis AG (Switzerland) 86

Novo Nordisk A/S (Denmark) 87

Table 33: Novo-Nordisk (2008-2010): Annual Sales for HRT

Drugs/Products (In DKKm) (includes corresponding

Graph/Chart) 87

B.Market Analytics 88

Table 34: Rest of European Recent Past, Current & Future

Analysis for Hormone Replacement Therapy (HRT) Market

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2009 through 2017 (includes corresponding

Graph/Chart) 88

Table 35: Rest of European Historic Review for Hormone

Replacement Therapy (HRT) Market Independently Analyzed with

Annual Sales Figures in US$ Million for Years 2003 through

2008 (includes corresponding Graph/Chart) 89

11. ASIA-PACIFIC 90

Market Analysis 90

Table 36: Asia-Pacific Recent Past, Current & Future

Analysis for Hormone Replacement Therapy (HRT) Market

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2009 through 2017 (includes corresponding

Graph/Chart) 90

Table 37: Asia-Pacific Historic Review for Hormone

Replacement Therapy (HRT) Market Independently Analyzed with

Annual Sales Figures in US$ Million for Years 2003 through

2008 (includes corresponding Graph/Chart) 91

12. REST OF WORLD 92

A. Market Analytics 92

Teva Pharmaceutical Industries Ltd. (Israel) - A Key Player 92

B.Market Analytics 93

Table 38: Rest of World Recent Past, Current & Future

Analysis for Hormone Replacement Therapy (HRT) Market

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2009 through 2017 (includes corresponding

Graph/Chart) 93

Table 39: Rest of World Historic Review for Hormone

Replacement Therapy (HRT) Market Independently Analyzed with

Annual Sales Figures in US$ Million for Years 2003 through

2008 (includes corresponding Graph/Chart) 94

COMPETITIVE LANDSCAPE

Total Companies Profiled: 42 (including Divisions/Subsidiaries - 55)

Region/Country Players

The United States 36

Canada 2

Japan 2

Europe 12

France 1

Germany 2

The United Kingdom 2

Italy 1

Rest of Europe 6

Asia-Pacific (Excluding Japan) 1

Middle-East 2

To order this report:

Biological Therapy Industry: Global Hormone Replacement Therapy (HRT) Industry

Biological Therapy Business News

More  Industry Analysis and Insights

CONTACT:
Nicolas Bombourg
Reportlinker
Email: nbo@reportlinker.com
US: (805)652-2626
Intl: +1 805-652-2626


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