Navigation Links
Glivec(R) is the First Adjuvant Treatment Approved in the UK to Delay Return of Gastrointestinal Cancer After Surgery
Date:5/7/2009

currence and provide reassurance to patients who live with the realities of GIST."

Glivec is now licensed to be used to treat patients at significant risk of relapse following the removal of their tumour following approval from the European Medicines Agency (EMEA). The EMEA (the body responsible for the scientific evaluation of applications for European authorisation for medicinal products) says that patients who have a low or very low risk of recurrence should not receive adjuvant treatment.(1)

What is GIST?

GIST is a type of cancer called a soft tissue sarcoma i.e. a cancer of a supportive or connective tissue in the body such as fat, muscle, blood vessels, deep skin tissues, nerves, bones and cartilage.(8) GISTs develop primarily along the gastrointestinal tract (digestive system) and often spread within the abdomen.(9)

Although the cause of GIST is unknown,(10) 75-80% of people with GIST carry KIT mutations.(11) KIT is a protein in the body that plays an important role in the growth and survival of GIST.(12) In patients with GIST, the KIT protein can mutate and become over active.(5)

The normal role of KIT is to provide the 'signal' to cells in the body to grow and divide: this signal is not given continuously but can be turned 'on' and 'off' to limit cell division and growth. However, in people with GIST, a mutation in the DNA causes KIT to be continuously activated. Left 'on' all the time, KIT signals to cells to constantly grow and divide, driving the growth of GIST.(5)

Glivec in GIST

Glivec is a type of treatment called a tyrosine kinase inhibitor.(13) It works in GIST by targeting the KIT protein, binding to it and preventing it from sending continuous signals to the cancer cells to grow and divide.(14) Glivec has been available to treat people with unresectable GIST (GIST that cannot be removed through surgery) since 2002, but currently m
'/>"/>

SOURCE Novartis Oncology
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Launch of Highly Targeted Cancer Treatment Tasigna(R) (nilotinib) Offers Potential Lifeline to Ph+ CML Patients Intolerant or Resistant to Existing Therapies, Including Glivec(R) (imatinib)
2. Bionovo Announces First Quarter 2009 Highlights and Financial Results
3. Alexza Reports 2009 First Quarter Financial Results and Updates Clinical Pipeline Status
4. BioCryst Pharmaceuticals to Announce Peramivir Update and First Quarter 2009 Financial Results on May 8, 2009
5. Poniard Pharmaceuticals Reports First Quarter 2009 Financial Results and Provides a Corporate Update
6. Transcept Pharmaceuticals to Report First Quarter 2009 Results
7. Video: ev3 Inc. Announces First Patient Enrollments in DEFINITIVE LE Post-Market Study
8. Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2009 First Quarter Results
9. Cepheid Announces European Release of First On-Demand Molecular Test for Simultaneous Detection of Mycobacterium tuberculosis (TB) and Resistance to Rifampicin
10. First Candidate from Esperances Targeted Anti-cancer Platform, EP-100, Establishes Preclinical Proof of Concept
11. Oakwood Surgeons Perform Worlds First 3D Surgery Without Special Glasses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... , July 30, 2015 ... research report with market overview, trends, DRO ... porter analysis, recent developments, competitive scenario and ... Industry Insight: Biosensors Market Development and Demand ... http://photos.prnewswire.com/prnh/20150727/756778 ) Explore more ...
(Date:7/30/2015)... , July 30, 2015 Vermillion, ... on gynecologic disease, announced today it will ... after the market close on Thursday, August ... call and webcast at 4:30pm Eastern.Conference Call ... at 4:30pm Eastern/1:30pm Pacific  Domestic: ...
(Date:7/30/2015)... What can be expected from the ... grow at the fastest rates? Visiongain ,s brand ... data, trends, opportunities and prospects there. Our ... graphs. Discover the most lucrative areas in the industry ... you assess forecasted sales at overall world market and ...
Breaking Medicine Technology:Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 2Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 3Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 4Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 5Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 2Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 3Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 4Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 5Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 6
... 2011 The University of California, Los Angeles (UCLA) ... soon become the third oncology research center in the ... a privately held medical device company. ViewRay,s new research ... patented combination of radiotherapy delivery and simultaneous magnetic resonance ...
... Nearly three quarters of the medical ... from developed markets, but the next wave of growth is ... unique needs of the India market, according to preliminary findings ... which were presented today at AdvaMed 2011, the annual MedTech ...
Cached Medicine Technology:UCLA Health System - Jonsson Comprehensive Cancer Center to Acquire ViewRay Radiation Therapy Research System 2Made in India, for India, is Next Wave of Growth for Region's Medical Technology Sector 2Made in India, for India, is Next Wave of Growth for Region's Medical Technology Sector 3
(Date:7/30/2015)... ... July 30, 2015 , ... Google recently announced that it will be ... As discussed in a June 8, 2015 article published by Nasdaq , the ... been caused by its computer-driven cars, which such industry players as Tesla CEO Elon ...
(Date:7/30/2015)... ... July 30, 2015 , ... " DevExpress ” ... a look at small, medium, and large businesses making an impact in their ... business review and shared with viewers how DevExpress has provided software development tools ...
(Date:7/30/2015)... ... , ... 24/7 Care At Home, a high-quality provider of comprehensive home health ... Centers for Medicare and Medicaid (CMS) have awarded its agency the highest star rating ... Home’s agency is one of three top Orange County agencies to earn the 5-Star ...
(Date:7/30/2015)... ... July 30, 2015 , ... The need for accessibility is never greater than ... to patients as well as visiting friends and family during these critical moments, hospitals ... The stations - powered by ChargeItSpot , a Philadelphia-based startup that recently secured ...
(Date:7/30/2015)... ... July 30, 2015 , ... OncLive®’s extensive ... UCLA’s Jonsson Comprehensive Cancer Center (JCCC) mutually agreed to collaborate on projects ... editorial and marketing groups will help spread the news about the center’s leading-edge ...
Breaking Medicine News(10 mins):Health News:New Google Policy on Reporting Driverless Auto Accidents Points Out Growing Complexity of Personal Injury Law in the 21st Century, Says Law Offices of Burg and Brock 2Health News:New Google Policy on Reporting Driverless Auto Accidents Points Out Growing Complexity of Personal Injury Law in the 21st Century, Says Law Offices of Burg and Brock 3Health News:Software to Develop High-Performance Data-Driven Apps was Featured on NewsWatch Television 2Health News:24/7 Care At Home Earns a 5-Star Rating from the Centers for Medicare and Medicaid (CMS) 2Health News:Hospitals Add Phone Charging Stations as an Amenity for Patients and Visitors 2Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 2Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 3Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 4
... Financial Flexibility - , , LAVAL, QC, June 25 ... ) today announced it has amended its debt facility agreement ... ). , Based on regulatory approval and recent launch of ... has been able to establish more favourable repayment terms. Under ...
... , Social commentator and vegan Ben Shaberman collects humorous ... , BALTIMORE, June 25 Apprentice House announces publication ... which guides readers through the world of being vegan, ... world of carnivores. Whether explaining how vegetarian guys ...
... , Product innovation designed to meet growing consumer demand for ... new line of High Fiber soups from Progresso(R), available in ... for taste, nutritional value and variety among ready-to-serve soups. , ... ingredient to positively impact health, 9 in 10 Americans are ...
... Can Help Americans Improve their Diets, Health and Energy , , NEW YORK, ... Friedrich today announced they are teaming up to help Americans make fitness and healthy ... and exercise, the partners will debut their " EB to ... etter + E at ...
... ... published in the British Journal of Nutrition (a Cambridge University Journal), clearly shows that ... , ... 2009 -- In a revolutionary healthcare finding, a peer-reviewed clinical study published in the ...
... , ... effort to more accurately reflect the service their Recruiters provide and the relationships they ... of their Recruiters to Career Consultants. , ... Omaha, NE (PRWEB) June 25, 2009 -- In an effort ...
Cached Medicine News:Health News:Labopharm amends debt facility agreement with Hercules 2Health News:Labopharm amends debt facility agreement with Hercules 3Health News:The Vegan Monologues Asks the Burning Question: Is That a Carrot in Your Pocket? 2Health News:Progresso(R) to Launch New High Fiber Soup Line in Fall 2009 2Health News:Eggland's Best and Award-Winning Fitness Trainer Cathe Friedrich Launch National Health and Fitness Program 2Health News:Eggland's Best and Award-Winning Fitness Trainer Cathe Friedrich Launch National Health and Fitness Program 3Health News:Eggland's Best and Award-Winning Fitness Trainer Cathe Friedrich Launch National Health and Fitness Program 4Health News:New Study Shows that Prebiotics, as Used by Jackson GI Medical, Increases Lifespan by 33% 2Health News:Traveling Healthcare Staffing Company, Medical Solutions, Announces a Ttitle change for its Recruiters to Career Consultants 2Health News:Traveling Healthcare Staffing Company, Medical Solutions, Announces a Ttitle change for its Recruiters to Career Consultants 3
Anti Gliadin IgA Enzyme Immunosay for quantitative determination of Gliadin-IgG antibodies in serum....
... high throughput primary or backup instrument, ... performance and reliability equal to or ... The advanced technology of the AUTION ... delivers reproducible and accurate results, limiting ...
Assay uses highly specific rabbit anti-estriol antibody reparation - negligible cross-reactivity with other estrogen metabolites. Excellent assay precision and reproducibility. Superior sensitivity ...
... Estrone Sulfate (E1S) is the most abundant ... as normal men [1,2]. Estrone Sulfate is ... and has a longer half-life in blood ... generally parallel those of estrone and estradiol, ...
Medicine Products: