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GlaxoSmithKline Share Their Insight on Understanding DDI With a View to Better Prediction and Control

LONDON, June 28, 2012 /PRNewswire/ --

Pharma IQ has released a new interview with Dr. James Clarke, Senior Scientist, GlaxoSmithKline, on the biggest challenges for clinically relevant drug transporters that GSK faces.

In this exclusive podcast Dr. Clarke shares his knowledge on how drug transporters exert a vital influence on drug absorption, disposition, metabolism and elimination and why they are an essential part of predicting drug disposition. He provides ideas on how the current technology landscape changed following the publication of the ITC white paper and the progress we can expect to see in clinically relevant drug transporters.

This interview was created as a part of the pre-conference research for the 3rd Annual Clinically Relevant Drug Transporters, taking place from the 22nd- 24th  October, 2012 in London.

The interview helped to shape the summit agenda which features among others - Eva Gil Berglund, PhD, Medical Products Agency, Sweden and Keith Hoffmaster, Senior Investigator from Novartis (ITC member) who provide an insight into new developments in the FDA / EMA transporter interaction Draft Guidance Papers.

Other important topics which will be discussed at the event include:

  • Model-based Prediction of Transporter-mediated Disposition and DDIs (Manthena Varma, Principle Scientist, Pfizer)
  • Drug Targeting: how can we use Uptake Transporters to achieve CNS or Tumour Penetration  (Maarten Huisman, Janssen Pharmaceutical Companies)
  • De-risking conjugated metabolites for causing transporter DDI with toxicological implications (Timothy Shultz - Utermoehl, Shire Pharmaceuticals)
  • Impact of "transporter-metabolism" and "transporter-transporter" interplay in Raloxifene Disposition (Jae Chang, Research Scientist, Genentech)

Press are invited to attend this important industry forum. If you would like to a complimentary press pass please email Joanna Checinska (

To access Dr. James Clarke's full interview or find out more about the Clinically Relevant Drug Transporters Summit please visit http://www.drugrtransporters/news, email or call +44(0)207-930-1300.

Media contact: Joanna Checinska, +44(0)20-7368-9807,  - Please contact for more information or images.

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