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Georgia Reproductive Specialists Participates in Largest-Ever In Vitro Fertilization Clinical Trial in the World
Date:8/19/2007

lity treatments, these medications can be mixed in a single syringe for convenient, once-daily administration.

ENDOMETRIN answers an unmet, significant patient need. ENDOMETRIN is not apainful shot, melting suppository, has no build-up, provides dose-to-dose consistency and is easily self-administered. If you would like to learn more about ENDOMETRIN, contact Georgia Reproductive Specialists at 404-843-2229. Georgia Reproductive Specialists can also provide you with information about MENOPUR and BRAVELLE.

Landmark IVF Trial

The safety and efficacy of ENDOMETRIN compared with an active control were evaluated in a multicenter, randomized, open-label, assessor-blinded trial in 1,211 women, ages 18-42, undergoing IVF. Efficacy was measured by continuing pregnancy and live birth rates. An analysis was also conducted to evaluate once-daily compared with twice-daily dosing of gonadotropins during the stimulation phase.

MENOPUR and BRAVELLE were used for the stimulation phase of IVF, with a minimum of one vial of MENOPUR per day. The centers had the option of combining Menopur and Bravelle and administering them as one single daily injection, which was done for approximately two-thirds of the patients (777). On the day of egg retrieval, patients were randomized to ENDOMETRIN 100 mg twice daily, ENDOMETRIN 100 mg three times daily, or an active control ((progesterone vaginal gel (90 mg) QD)).* In the study, 97 percent of patients randomized to participate in the trial received an embryo transfer.

The results showed that ENDOMETRIN was efficacious, with no significant differences in efficacy parameters between treatment arms. Continuing pregnancy rates were 44 percent with ENDOMETRIN TID and 40 percent with ENDOMETRIN BID. Live birth rates were also high: ENDOMETRIN BID 37 percent, ENDOMETRIN TID 40 percent. The groups showed equivalent tolerability, with no significant differences in the incidence of adverse events.

The efficacy of ENDOMET
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SOURCE Georgia Reproductive Specialists

Copyright©2007 PR Newswire.

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