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GeoVax Labs' CEO Update Letter to Shareholders
Date:1/9/2012

potential revenue value of such a product are in excess of $4 billion annually.

Preventative Vaccine Program

We are extremely fortunate to have the U.S. National Institutes of Health (NIH)-supported HIV Vaccine Trials Network (HVTN) continuing to conduct and fund our preventative vaccine trials. During 2011, several milestones were accomplished: (a) the publication of the results of our phase 1 clinical trial involving 120 participants, (b) the completion of enrollment of our phase 2a trial involving 300 participants and, (c) preparations for launching human clinical testing of the GM-CSF-adjuvanted form of our vaccine.

In the non-human primate model, the adjuvanted vaccine, which co-expresses GM-CSF in the DNA priming component, has shown outstanding and long lasting prevention (not just control) of infection. Because of its superior ability to prevent infection, our plan is to take the adjuvanted vaccine into efficacy trials launched as soon as late 2013.

Last month, it was announced that an application for FDA approval is being sought for a once-daily drug to reduce the risk of HIV infection among uninfected adults. While this made headlines and is a wonderful step toward the prevention of HIV infection, this is not a long-term practical solution to prevent infection. Medication and physician costs, side effects and patient compliance continue to be significant issues that such a drug regimen doesn't adequately address. Although you will read that individuals can achieve 73% protection if they faithfully take this drug, required strict adherence to the necessary prescribed drug therapy is rare. Once a vaccine is available, this method of prevention will no longer be an attractive option.  Similar to the market value for a therapeutic vaccine, current market estimates for a preventative vaccine exceed $4 billion annually.

An article in Nature published this month by researchers at Harvard Medical School
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SOURCE GeoVax Labs, Inc.
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Related medicine technology :

1. GeoVax Labs First Patient Inoculated in Phase 1/2 Clinical Trial for HIV/AIDS Therapeutic Vaccine
2. GeoVax Phase 2a Clinical Trial Completes Enrollment
3. GeoVax $3.6 Million Award Increased to $4.4 Million by U.S. Government
4. GeoVax Labs, Inc. Announces Second Quarter Financial Results
5. GeoVax Labs HIV/AIDS Vaccine Development Leadership to be Highlighted During 2011 World Vaccine Congress
6. GeoVax Announces Publication of Phase 1 Clinical Trial in The Journal of Infectious Diseases
7. GeoVax Launches a Second Clinical Site to Test the Therapeutic Benefit of its HIV Vaccine
8. David A. Dodd Appointed Chairman of the Board of GeoVax Labs
9. GeoVax Announces Expansion of Phase 2a Human HIV/AIDS Vaccine Trial
10. GeoVax Awarded Federal Grant Under the Qualifying Therapeutic Discovery Project Program
11. GeoVax Labs Engages The Investor Relations Group
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