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GeoVax Labs, Inc. Third Quarter Financial Results and Operational Update
Date:11/15/2007

s in non-human primates

clearly show this Ab correlates with protection.

* GeoVax vaccines use an attenuated smallpox vaccine to provide

pulses of HIV proteins (antigen) to stimulate protective anti-AIDS

vaccine responses. Pulses of antigen from the GeoVax vaccines

elicit T cell responses that rapidly mobilize and then contract

into a state called "central memory" from which they rapidly expand

to fight the appearance of HIV.

-- In November, GeoVax announced excellent safety and immunogenicity

data from its full-dose HIV/AIDS vaccine human trial which began in

September 2006. This full-dose trial is the second in a series of four

Phase 1 human trials designed to test the safety and immunogenicity of

the GeoVax HIV/AIDS vaccines. Involving 36 participants of which 30

received vaccine and 6 received placebo, this trial protocol included

vaccination with two full-doses of GeoVax's DNA vaccine to prime the

immune response followed by two full-doses of GeoVax's MVA vaccine to

boost the immune response. GeoVax's DNA and MVA vaccines express over

50% of the AIDS virus (HIV-1) protein components in order to stimulate

a broad anti-HIV immune response. The vaccines cannot cause AIDS

because they do not include complete virus. A Phase 1 human trial,

started in April 2006, evaluated the delivery of only 1/10th of the

full dosage and utilized the same vaccine regimen evaluated in the full

dose trial.

From data collected from the 26 participants who completed the

trial, the following positive conclusions were observed:

* GeoVax HIV/AIDS vaccines, both DNA and MVA, continue to demonstrate

that they are quite safe and immunogenic following the delivery of

the four full-doses (two of each vaccine) used in th
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SOURCE GeoVax Labs, Inc.
Copyright©2007 PR Newswire.
All rights reserved

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