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GeoVax Labs, Inc. Third Quarter Financial Results and Operational Update

ng Board recommended that the trial be

stopped because it was not reaching its efficacy endpoints. GeoVax

responded to the discontinuance of Merck's trial by pointing out

significant differences between the GeoVax vaccine technology and the

technology used in the Merck trial.

GeoVax AIDS vaccines advancing in human trials represent a

significantly different vaccine approach, vaccine composition and

results to date than the Merck vaccine.

* Prototypes for the GeoVax vaccines were selected from a series of

trials in non-human primates for their ability to protect against

the development of AIDS when vaccinated individuals were

administered an AIDS causing virus. At each major step along the

development pathway, GeoVax vaccines providing the best protection

against AIDS were moved forward.

* GeoVax AIDS vaccines demonstrated excellent protective results in

non-human primate models, much better protective results than

reported for Merck's vaccine in similar models. GeoVax AIDS

vaccines protected 22/23 non-human primates for over 3 1/2 years

and 5/6 non-vaccinated controls died of AIDS post-AIDS virus


* GeoVax AIDS vaccines are designed to elicit protective antibodies

(Ab) as well as protective T cells (white blood cells) against the

AIDS virus. The Merck vaccine stimulates only T cells for providing

protection and does not include the Env protein of HIV which is the

target for protective antibody (Ab).

* Protective Ab has been difficult to elicit with HIV/AIDS vaccines.

GeoVax has approached this challenge by vaccinating with the

natural form of Env (HIV envelope antigens) under conditions that

elicit tightly binding Ab. GeoVax studie

SOURCE GeoVax Labs, Inc.
Copyright©2007 PR Newswire.
All rights reserved

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