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vaccine regimen employs a two-vaccine "prime-boost strategy." Trial
participants will be administered GeoVax HIV-1 DNA vaccine which
"primes" the immune system followed by GeoVax's HIV-1 MVA (Modified
Vaccinia Virus) boost. Both vaccines deliver over 50% of the AIDS virus
components but can not cause AIDS. Safety and immunological results
from earlier as well as ongoing human trials are very encouraging thus
supporting planned acceleration of large scale Phase 2 clinical
studies.
-- In September, GeoVax announced receipt of an estimated $15 million
Integrated Preclinical/Clinical AIDS Vaccine Development [IPCAVD] Grant
to support its HIV/AIDS vaccine program. This large Grant was awarded
by the National Institutes of Health-National Institute of Allergy &
Infectious Disease [NIH-NIAID], an agency of the U.S. Government. The
grant funding period is over a five year period commencing October
2007. Only meritorious HIV/AIDS prevention vaccine candidates are
considered to receive an IPCAVD award. Candidate companies are highly
scrutinized and must supply substantial positive AIDS vaccine data to
support their application. IPCAVD grants are awarded on a competitive
basis and are designed to support later stage vaccine research,
development and human trials. GeoVax will utilize this funding to
further its HIV/AIDS vaccine development, optimization, production and
human clinical trial testing.
GeoVax announced in January 2008 that it had been recognized by Georgia
Bio, the state trade organization, as a 2007 "Deal of the Year" award
winner for receipt of the $15 million IPCAVD grant.
-- In September, GeoVax announced the presentation of successful human
trial results for its HIV/AIDS vaccines at the
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