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GeoVax Announces Publication of Phase 1 Clinical Trial in The Journal of Infectious Diseases
Date:2/23/2011

ATLANTA, Feb. 23, 2011 /PRNewswire/ -- GeoVax Labs, Inc. (OTC Bulletin Board: GOVX) announced today the publication of the results of Phase 1 clinical trial testing of its HIV/AIDS vaccine products. The article, titled "Phase 1 Safety and Immunogenicity Testing of DNA and Recombinant Modified Vaccinia Ankara Vaccines Expressing HIV-1 Virus-like Particles," will appear in the March 1 issue of The Journal of Infectious Diseases. A PDF of the article is available at the following URL:

http://jid.oxfordjournals.org/cgi/reprint/jiq105?ijkey=nT44dx1yCxsiOjV&keytype=ref.

GeoVax is developing two vaccine components: a recombinant DNA-vectored vaccine; and a recombinant MVA-vectored vaccine. Both produce non-infectious virus-like particles in the body of a vaccine recipient. These non-infectious particles are designed to "train" the immune system of the vaccinated person to recognize HIV should the vaccinated person be exposed to the real virus. Both the DNA and MVA vaccines induce humoral (antibody) and cellular (T cell) responses. Antibodies have the potential to block virus before it infects cells. The T cells have the potential to recognize and kill cells that become infected by virus that gets past the antibody.

The publication reports the results of three different trial regimens:  (1) priming with two doses of the pGA2/JS7 recombinant DNA vaccine and boosting with two doses of MVA/HIV62B recombinant MVA vaccine (DDMM regimen); (2) priming with one dose of the recombinant DNA and boosting with two doses of the recombinant MVA (DMM regimen); and (3) priming and boosting with a total of three doses of the recombinant MVA vaccine (MMM regimen). The Phase 1 trial, initiated in 2006 and completed in 2009, included 120 participants, was sponsored by
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SOURCE GeoVax Labs, Inc.
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Related medicine technology :

1. GeoVax Launches a Second Clinical Site to Test the Therapeutic Benefit of its HIV Vaccine
2. David A. Dodd Appointed Chairman of the Board of GeoVax Labs
3. GeoVax Announces Expansion of Phase 2a Human HIV/AIDS Vaccine Trial
4. GeoVax Awarded Federal Grant Under the Qualifying Therapeutic Discovery Project Program
5. GeoVax Labs Engages The Investor Relations Group
6. GeoVax Labs, Inc. Reports Fourth Quarter and Year End 2009 Financial Results
7. GeoVax Labs, Inc. Plans Public Offering
8. GeoVax Labs, Inc. Begins Enrollment at Final Site for Preventative Vaccine; Next Step Is to Submit IND Application for Therapeutic Vaccine to FDA
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10. GeoVax Labs, Inc. Provides Third Quarter 2009 Financial Results and Operational Update
11. GeoVax Labs, Inc. Announces Results of 2009 Annual Shareholders Meeting
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