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Genzyme and Isis Begin Second Phase 3 Trial Of Mipomersen
Date:8/6/2008

Broad New Patent Granted

CAMBRIDGE, Mass. and CARLSBAD, Calif., Aug. 6 /PRNewswire-FirstCall/ -- Genzyme Corp. (Nasdaq: GENZ) and Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) today announced that they have begun a phase 3 study of mipomersen in patients with heterozygous familial hypercholesterolemia (heFH), a genetic disorder that causes exceptionally high levels of LDL cholesterol. It is the first of four new trials the companies plan to initiate by the end of this year, and the second late-stage study of mipomersen, a novel lipid-lowering drug that utilizes antisense technology.

The companies also announced that the United States Patent and Trademark Office granted the patent entitled "Antisense Modulation of Apolipoprotein B (apoB) Expression," U.S. Patent No. 7,407,943. The patent broadly covers the use of antisense compounds targeting the apoB messenger RNA except a ribozyme.

"We are making excellent progress in implementing our comprehensive development plan for mipomersen," stated John P. Butler, president of Genzyme's renal, endocrine and cardiovascular business units. "The start of the heFH study puts us on track to meet our goal of beginning four new mipomersen studies this year. In addition, the recent patent issuance increases the overall value of mipomersen, which we believe has enormous potential to help patients."

The new trial will evaluate the safety and efficacy of mipomersen in patients who have heFH and coronary artery disease. It is a randomized, dou
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SOURCE Genzyme Corp.; Isis Pharmaceuticals, Inc.
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