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Genzyme Announces Presentation of New Positive Data on Carticel(R)
Date:3/10/2008

d not undergone a marrow stimulation technique prior to treatment with ACI.

"The data show that in this patient population marrow stimulation techniques like microfracture are not benign and can compromise a patient's ability to benefit from a subsequent treatment with ACI, effectively limiting their future treatment options," said Tom Minas, MD, an internationally renowned orthopaedic surgeon for his extensive work in the field of Cartilage Repair and principal investigator in this study. "Orthopaedic surgeons should reconsider using marrow stimulation techniques as first-line treatment for patients with larger chondral lesions. These techniques should be reserved for patients with smaller defects, in younger patients, where a good result is more predictable."

A Unique Cell Therapy

More than 14,000 patients in the United States have had Carticel implants. Carticel is used by orthopaedic surgeons to treat patients who have clinically significant articular cartilage lesions on the thigh bone part of the knee caused by acute or repetitive trauma that have not responded to a prior cartilage repair procedure. Carticel should only be used in conjunction with debridement, placement of a periosteal flap and rehabilitation. The independent contributions of the autologous cultured chondrocytes and other components of the therapy to outcome are unknown. Carticel employs a unique process to grow a patient's own cartilage cells for implantation to correct certain types of damage. The treatment starts when an orthopaedic surgeon trained in the use of Carticel provides Genzyme with a biopsy of healthy cartilage taken from a patient's knee in an arthroscopic procedure. Technicians at Genzyme's cell culture laboratory in Cambridge, MA, use proprietary methods to grow millions of cells from this biopsy. The cells are then delivered to the hospital, where the surgeon implants them into the patient's knee defect in a surgical procedure.

Carticel was the fir
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SOURCE Genzyme Corporation
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