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Genus Oncology, LLC Announces Initiation of Phase I Trial of GO-203-2c in Patients With Solid Tumors
Date:2/15/2011

O-203-2c. Up to 40 patients will be enrolled in the study at multiple clinical sites. The sites currently contracted to conduct the Phase I trial are the University of Texas Health Science Center at San Antonio (UTHSCSA) and the Virginia G. Piper Cancer Center at Scottsdale Healthcare Hospital. Additional sites are currently under consideration.

"We are very enthusiastic to participate in this clinical trial with a promising and innovative targeted therapy. We are excited to have identified the first patient to be treated in the study and will work diligently together with our colleagues from TGen as well as with our partners from Genus to achieve the study goals," said Dr. Alain Mita, Director of the Advanced Fellowship Program in Drug Development at UTHSCSA.

"We are excited to work with a distinguished team at Genus Oncology and Harvard Medical School," said Dr. Ramesh Ramanathan, Medical Director, TGen Clinical Research Services at Scottsdale Healthcare. "In normal cells MUC1, a mucin, coats the intestine and other organs and prevents penetration of bacteria and other pathogens. The MUC1 protein is abnormal and present in high concentrations in cancer cells and appears to be important in cancer cell growth; and GO-203-2c is one of the first peptides to specifically target this molecule."

About GO-203-2c

GO-203-2c is the optimized lead peptide drug candidate from a series of first-in-class agents synthesized to target MUC1, an oncoprotein that is over-expressed in many diverse human carcinomas including breast, prostate, lung, colon, pancreas, and ovary that have been associated with poor prognosis. Of an estimated 1.4 million cancer cases diagnosed each year in the US, about 900,000 over-express MUC1, thus making it an attractive target for developing anti-cancer drugs. To date, there are no approved agents that target MUC1.

About Genus Oncology, LLC

Genus Oncology, LLC, is a clinical-stage company formed
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SOURCE Genus Oncology, LLC
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