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Genomic Health Presents Ten New Studies in Breast, Colon and Prostate Cancers at the American Society of Clinical Oncology (ASCO) Annual Meeting
Date:6/4/2011

" (Abstract #592) will be presented on Monday, June 6.
  • Initial data from the prospective, multicenter West German Study Group (WSG) Plan B trial examined the relationship between tumor grade and the tumor immunohistochemistry biomarker, Ki-67, the invasion markers uPA (urokinase-type plasminogen activator) and its inhibitor PAI-1, and the Oncotype DX Recurrence Score. Results from a preliminary analysis of 1,795 patients showed that there were only weak correlations between all the markers and the Recurrence Score. These results reinforce the conclusion that the Recurrence Score result cannot be predicted by other clinicopathologic measures. The study, "Prospective comparison of recurrence score, uPA/PAI-1, central grade and molecular classification in early breast cancer: Interim results from the WSG-Plan B trial" (Abstract #10594) will be presented on Monday, June 6.
  • Results from an analysis of 5,644 early-stage breast cancer patients from a large US-based oncology group practice concluded that younger patients and patients who had better performance status and higher grade tumors were more likely to receive the Oncotype DX test.  The study, "Evaluating utilization characteristics for the Oncotype DX recurrence score in early-stage breast cancer" (Abstract #625) will be presented on Monday, June 6.
  • Finally, an analysis of 1,543 early-stage breast cancer patients from a large US-based oncology group practice demonstrated a strong association between RS values and adjuvant chemotherapy administration.  This study, "Evaluation of relation between Oncotype DX recurrence score and adjuvant chemotherapy administration" (Abstract #e11105) will be published online in conjunction with the 2011 Annual Meeting and citable to the Journal of Clinical Oncology as a supplement, but will not be presented at the meeting. 

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