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Genomic Health Presents Ten New Studies in Breast, Colon and Prostate Cancers at the American Society of Clinical Oncology (ASCO) Annual Meeting
Date:6/4/2011

eatment for HER2-negative breast cancer, tumors with higher Oncotype DX Recurrence Scores at baseline were more likely to achieve a pathologic complete response.  The study, "Ixabepilone and cyclophosphamide as neoadjuvant therapy in HER2-negative breast cancer with exploratory Oncotype DX assessments: A Sarah Cannon Research Institute phase II trial" (Abstract #1066) will be presented on Monday, June 6.

Breast Cancer Recurrence Score Cannot Be Predicted by Traditional Clinicopathologic Measures

  • An analysis of 2,097 patients from Clalit Health Services and 484 patients from Maccabi Health Services in Tel Aviv, Israel who received the Oncotype DX breast cancer tests between January 2008 and June 2010 concluded that the RS result cannot be predicted by traditional clinicopathologic measures, such as patient age, tumor grade, and tumor size.  The study, "Evaluation of recurrence score and traditional clinicopathologic assessments in a large ER-positive, lymph node-negative patient cohort" (Abstract #632) will be presented on Monday, June 6.

Additional Breast Cancer Studies Expand Understanding of Tumor Biology

  • Based on published data comparing the relative efficacy of aromatase inhibitors and tamoxifen in reducing the risk of distant recurrence, researchers concluded that an individual patient's Recurrence Score and Recurrence Score-Clinical-Pathologic (RSPC) distant recurrence risk assessment can be used to determine distant recurrence risk for early-stage breast cancer patients receiving treatment with an aromatase inhibitor.  The study, "Using the 21-gene Recurrence Score (RS) and the recently developed Recurrence Score-Pathology-Clinical (RSPC) to assess recurrence risk in patients with node-negative, ER-positive early-stage breast cancer receiving aromatase inhibitor treatment alone
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SOURCE Genomic Health, Inc.
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