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Genomic Health Presents Ten New Studies in Breast, Colon and Prostate Cancers at the American Society of Clinical Oncology (ASCO) Annual Meeting
Date:6/4/2011

ickman Urological and Kidney Institute at the Cleveland Clinic in Cleveland, Ohio. "If physicians had a better tool for more accurately determining whether or not a patient's disease is clinically significant, many men could avoid radiation therapy or surgery, as well as common treatment-related side effects such as loss of sexual function and incontinence."  

Results of a quantitative RT-PCR analysis of RNA specimens from 441 prostate cancer patients treated with radical prostatectomy (RP) at Cleveland Clinic between 1987 and 2004 identified 295 genes strongly associated with clinical cancer recurrence following radical prostatectomy.  The study, "Quantitative gene expression in primary and highest Gleason pattern cancer specimens identifies genes associated with clinical recurrence and prostate cancer -- specific survival after radical prostatectomy" (Abstract #4663) will be presented on Sunday, June 5.

A separate analysis of RNA from the same specimens indicated that there is no association of expression of TMPRSS2-ERG fusions or ERG expression with aggressiveness of prostate cancer after RP.  The study, "Use of TMPRSS2-ERG gene rearrangement and quantitative ERG expression to predict clinical recurrence after radical prostatectomy" (Abstract #4541) will be presented during a poster discussions session on Saturday, June 4.

Breast Cancer:

"This new analysis in the Canadian healthcare system reinforces evidence from multiple countries that use of the Oncotype DX assay to predict recurrence and response to adjuvant chemotherapy for women with early stage breast cancer provides good value for money," said John Hornberger, MD, MS, CEO, Cedar Associates and Adjunct Professor of Medicine, Stanford.  "Appropriate use of a clinically validated test that uncovers underlying biology that cannot be predicted by traditional clinical-pathologic measures, such as Oncotype DX
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SOURCE Genomic Health, Inc.
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