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Genomic Health Announces Publication of Study Using Oncotype DX(R) in Node-Negative and Node-Positive Breast Cancer Patients Treated With Aromatase Inhibitors
Date:3/8/2010

The study used Oncotype DX to analyze tumor samples from 1,231 patients involved in the landmark ATAC (Arimidex®, Tamoxifen, Alone or in Combination) trial, which established the extensive use of aromatase inhibitors for adjuvant treatment of postmenopausal women with hormone receptor-positive breast cancer. Nine-year distant recurrence was assessed for women in the anastrozole and tamoxifen monotherapy arms of the ATAC trial, including patients with disease that had spread to the lymph nodes (0 nodes, 1-3 nodes and 4 or more nodes).

Researchers collected tumor blocks primarily from patients in the United Kingdom and tested the significance of adding the RS result to a clinical model consisting of age, tumor size, grade and treatment, as well Adjuvant! Online, a valid risk assessment tool that evaluates clinical variables to help physicians and patients assess the risks and benefits of getting additional therapy after surgery.

Results indicated that the RS result provided statistically significant prognostic value beyond that provided by Adjuvant! Online in node-negative (p<0.001) patients. While the study confirmed the performance of the RS result in a large contemporary patient population of postmenopausal hormone receptor-p
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SOURCE Genomic Health
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