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Genomic Health Announces Positive Results of First Clinical Outcomes Study for Biomarker Discovery Using Next Generation Sequencing at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium
Date:12/8/2011

ielding 43 million reads per each duplexed sample, 69 percent of which uniquely map to the human genome.  Standardized hazard ratios and p-values for the 21 Oncotype DX genes determined by RNA-Seq were comparable to those originally obtained using RT-PCR.  Additionally, whole transcriptome RNA-Seq revealed more than 1,800 new coding and non-coding RNAs associated with breast cancer recurrence risk, many of which belong to previously unrecognized gene networks. Additional research will be performed to determine whether these new genes can be observed in other cohorts and whether they add value beyond the 21 Oncotype DX genes.

The study, "Breast Cancer Recurrence Risk Probed by Whole Transcriptome Next-Generation Sequencing in 136 Patients," is presented on Thursday, December 8 at 7:00 a.m. CT.

About Genomic Health and the Oncotype DX® Tests
Genomic Health, Inc. (NASDAQ: GHDX) is a molecular diagnostics company focused on the global development and commercialization of genomic-based clinical laboratory services that analyze the underlying biology of cancer allowing physicians and patients to make individualized treatment decisions.

Its lead product, the Oncotype DX Breast Cancer test, has been shown to predict the likelihood of chemotherapy benefit as well as recurrence in early-stage breast cancer to help optimize treatment options.  Oncotype DX is the only test incorporated in published ASCO® and NCCN® breast cancer treatment guidelines for patients with node-negative breast cancer that is estrogen-receptor positive and/or progesterone-receptor positive.(1)  The test is also recognized in international guidelines issued by St. Gallen International Breast Cancer Expert Panel and European Society for Medical On
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SOURCE Genomic Health, Inc.
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