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Genomic Health Announces Positive Results of First Clinical Outcomes Study for Biomarker Discovery Using Next Generation Sequencing at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium
Date:12/8/2011

SAN ANTONIO, Dec. 8, 2011 /PRNewswire/ -- Genomic Health, Inc. (Nasdaq: GHDX) today announced the presentation of the first-of-its-kind clinical outcomes study for biomarker discovery applying next generation sequencing (NGS) for whole transcriptome profiling of archival formalin-fixed paraffin embedded (FFPE) tumor specimens.  Results presented at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium demonstrate that a proprietary RNA-Seq method developed at the company is capable of identifying validated genes that previously had been discovered by RT-PCR, the technology used to develop the Oncotype DX® breast cancer test.  RNA-Seq refers to the use of high-throughput sequencing to identify which RNAs are expressed in a given sample and generate a quantitative gene expression profile by counting the number of RNA copies that match each gene or region of the genome.  The technology allows Genomic Health scientists to assay the entire genome simultaneously to discover regions of the genome that are turned on or off in disease.  From these changes, researchers are focused on predicting disease outcomes.  In addition to re-confirming the original 21 Oncotype DX genes originally identified by RT-PCR, this study also revealed more than 1,800 new biological relationships associated with breast cancer recurrence.

"This study marks an important milestone in the clinical application of next generation sequencing by establishing the biological and technical validity of a new proprietary method that accommodates very low amounts of RNA from fixed paraffin-embedded tumor tissue, and therefore is practical to use broadly for biomarker discovery and clinical development," said Joffre Baker, Ph.D, chief scientific officer, Genomic Health.  "These findings position Genomic Health to lead in the delivery of next generation cancer diagno
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SOURCE Genomic Health, Inc.
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