Navigation Links
Genomic Health Announces Positive Results of First Clinical Outcomes Study for Biomarker Discovery Using Next Generation Sequencing at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium
Date:12/8/2011

SAN ANTONIO, Dec. 8, 2011 /PRNewswire/ -- Genomic Health, Inc. (Nasdaq: GHDX) today announced the presentation of the first-of-its-kind clinical outcomes study for biomarker discovery applying next generation sequencing (NGS) for whole transcriptome profiling of archival formalin-fixed paraffin embedded (FFPE) tumor specimens.  Results presented at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium demonstrate that a proprietary RNA-Seq method developed at the company is capable of identifying validated genes that previously had been discovered by RT-PCR, the technology used to develop the Oncotype DX® breast cancer test.  RNA-Seq refers to the use of high-throughput sequencing to identify which RNAs are expressed in a given sample and generate a quantitative gene expression profile by counting the number of RNA copies that match each gene or region of the genome.  The technology allows Genomic Health scientists to assay the entire genome simultaneously to discover regions of the genome that are turned on or off in disease.  From these changes, researchers are focused on predicting disease outcomes.  In addition to re-confirming the original 21 Oncotype DX genes originally identified by RT-PCR, this study also revealed more than 1,800 new biological relationships associated with breast cancer recurrence.

"This study marks an important milestone in the clinical application of next generation sequencing by establishing the biological and technical validity of a new proprietary method that accommodates very low amounts of RNA from fixed paraffin-embedded tumor tissue, and therefore is practical to use broadly for biomarker discovery and clinical development," said Joffre Baker, Ph.D, chief scientific officer, Genomic Health.  "These findings position Genomic Health to lead in the delivery of next generation cancer diagno
'/>"/>

SOURCE Genomic Health, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Harvard Medical School-Partners HealthCare Center for Genetics and Genomics Successfully Completes Evaluation of AutoGenomics 2C9-VKORC1 Panel to Assess Warfarin Sensitivity
2. Harvard Medical School-Partners HealthCare Center for Genetics and Genomics Successfully Completes Evaluation of AutoGenomics 2C9-VKORC1 Panel to Assess Warfarin Sensitivity
3. Personalized Medicine - The Genomic Revolution in Cardiac Care
4. Virogenomics, Inc. Awarded $2 Million National Institute of Standards and Technology (NIST) Advanced Technology Program Grant to Develop Integrated Diagnostic Biosensors
5. Genomic Health Announces Preliminary Results From a Study of Oncotype DX(TM) in Node-Positive Breast Cancer Patients
6. Microarray Sequence Capture Speeds Large-Scale Resequencing of Targeted Genomic Regions
7. BiPar Genomic Biomarker Data Demonstrate Overexpression of PARP-1 Gene in Multiple Cancer Types
8. Genomic Health Announces Eight Oncotype DX(R) Studies to Be Presented at 30th Annual San Antonio Breast Cancer Symposium
9. Orion Genomics Announces the Discovery of Novel Breast Cancer Biomarkers
10. Genomic Health Announces Identification of Genes Associated With Colon Cancer Recurrence Across Multiple Studies
11. Transgenomic Announces New Contracts for Phase II Trials With Two Major Pharmaceutical Companies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... , Sept. 19, 2014 /PRNewswire-iReach/ -- Market ... Hydrochloride Industry, 2009-2019 is a professional and ... Oxybutynin Hydrochloride industry. The report firstly reviews ... its classification, application and manufacturing technology. The ... manufacturers of Oxybutynin Hydrochloride listing their product ...
(Date:9/19/2014)... CHICAGO, Ill. , Sept. 19, 2014  The ... ABBV ) declared a quarterly cash dividend of $0.42 ... payable Nov. 17, 2014 to stockholders of record at ... About AbbVie AbbVie is a global, research-based biopharmaceutical ... company,s mission is to use its expertise, dedicated people ...
(Date:9/19/2014)... -- Merck (NYSE: MRK ), known as MSD outside ... , is teaming with celebrity chef and cookbook author Leticia ... an educational program encouraging Hispanics with type 2 diabetes to achieve ... to help reduce the risk of serious health problems. Hispanics in ... risk for developing type 2 diabetes than non-Hispanic white adults, and ...
Breaking Medicine Technology:Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 3Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 4Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 5Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 2Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 3Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 4Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 5
(Date:9/22/2014)... 2014 One key emerging trend in ... investing in R&D to develop new and advanced biomaterial ... implants. The introduction of third-generation orthopedic biomaterials such as ... will increase the growth of the market in the ... market to grow at a CAGR of 10.78 ...
(Date:9/22/2014)... (PRWEB) September 22, 2014 AttorneyOne.com, a recognized ... latest information from the FDA on Twix . , ... Twix Unwrapped Bites 7 oz. Stand Up Pouch with specific ... for the recall is that Twix Unwrapped Bites ... contain peanuts and eggs without writing them on the ingredient ...
(Date:9/22/2014)... In CHAMPS Patient Experience's most recent blog ... Summer Meeting , Toya Gorley shares her thoughts on ... The Leader’s Board meeting this summer, which was comprised ... experience to be exhilarating! Many topics were discussed, including:, ... on the patient experience , Technology ...
(Date:9/22/2014)... September 22, 2014 Fancyflyingfox.com, the well-known wedding ... of 2014 plus size wedding dresses . In addition, ... for these fashionable plus size outfits. Each item in the ... up to 65% off. , The company has thousands ... them are now available at extremely affordable prices. Its products ...
(Date:9/21/2014)... cancer patients who smoke, those using e-cigarettes (in addition ... or less likely to have quit smoking traditional cigarettes ... a peer-reviewed journal of the American Cancer Society, the ... for helping cancer patients give up smoking. , Because ... who smoke should be advised to quit. But the ...
Breaking Medicine News(10 mins):Health News:Orthopedic Biomaterials Market to Grow at 10.78% CAGR by 2018, Forecasts a New Research Report at ReportsnReports.com 2Health News:Orthopedic Biomaterials Market to Grow at 10.78% CAGR by 2018, Forecasts a New Research Report at ReportsnReports.com 3Health News:Orthopedic Biomaterials Market to Grow at 10.78% CAGR by 2018, Forecasts a New Research Report at ReportsnReports.com 4Health News:Mars Chocolate North America Recalls Twix Bites: AttorneyOne Monitors and Keeps Consumers Informed 2Health News:CHAMPS' Toya Gorley Discusses the Thought-Provoking Conversation at The Leader’s Board Summer Meeting 2Health News:Discounted Plus Size Wedding Dresses Available At Fancyflyingfox.com 2Health News:E-cigarettes unhelpful in smoking cessation among cancer patients 2
... a changed version of dopamine// transporter in healthy ... with substance abuse or attention deficit hyperactivity disorder ... the hypothalamus and some areas of the central ... play an important role in hormonal, cardiovascular, renal ...
... is possible to increase the heights of children who ... improved dosages of the growth hormones. ,The researchers ... that the administration of the growth hormone GH-dependent hormone ... (IGF-I) can affect the growth of children in height. ...
... have found out new information about how neuro ... be possibly slowed. ,Researchers at the Rocky ... found novel insights into how abnormal prion proteins ... mice producing prion protein without a glycophosphoinositol (GPI) ...
... be used to detect cancer, says a new study that ... and son research team had been able to bind the ... that will make the tracing of cancer cells much easier. ... factor receptor (EFGR) over their surface. This protein is not ...
... be at less risk from colorectal// cancer. And women who ... B may have even reduced chance of having colorectal cancer. ... of abnormal or malignant cells within the lining of colon ... American researchers, said that inadequate intake of dietary vitamin B ...
... problems// like cognitive impairment in children. ,Researchers across the ... of pollutants like noise from the traffic and aircrafts on ... of 2844 children in the age group of 9 to ... Netherlands, Spain, and UK. Researchers had taken the help of ...
Cached Medicine News:
... The ACMI AEH-4 Electrohydraulic Lithotriptor combines efficient ... maintenance. Features include a large, clear LED ... power range setting according to probe size. ... to predict probe end-of-life, and can also ...
P-Series Cystourethroscope Short Bridge, examining...
Used for stone manipulation and removal in the urinary tract. The hollow shaft allows protected delivery of a laser fiber to an entrapped stone for fragmentation of the stone. Supplied sterile in pee...
Used for ureteral dilation and stone manipulation in the ureter. Supplied sterile in peel-open packages. Intended for one-time use....
Medicine Products: