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Genomic Health Announces New Data Reinforcing Clinical Utility of Oncotype DX(R) in Multiple Breast Cancer Populations
Date:12/15/2009

T-PCR analysis by Oncotype DX can successfully be performed on core biopsies that have been fixed and paraffin-embedded.
  • Previous studies have shown the Recurrence Score result to be associated with the likelihood of response to neoadjuvant therapy (i, ii, iii). Patients with a higher Recurrence Score result had a greater chance of experiencing a response from neoadjuvant chemotherapy while patients with a lower Recurrence Score appeared to be more likely to achieve a response from endocrine therapy. Genomic Health plans to further assess the role of Oncotype DX in the neoadjuvant setting through a number of ongoing clinical trials.

Exploratory Analysis of Gene Expression Identifies New Potential Therapeutic Targets, Biomarkers Associated with Recurrence

  • In a study presented Saturday, December 12, researchers analyzed 371 genes and compared expression levels between hormone receptor-positive breast cancer cases and hormone receptor-negative cases. A number of the genes tested exhibited significantly higher expression in hormone receptor-positive breast cancer and pathway analysis showed substantial interconnectivity among these genes. The analysis further revealed several pathways that exhibit higher expression in hormone receptor-positive disease - some of which were also associated with a higher risk of recurrence after chemohormonal therapy - suggesting that they may be potential therapeutic targets and providing a rationale for evaluating both currently available and investigational agents that target these pathways.

Oncotype DX and FISH Testing Both Detect Amplified HER2 Expression with Extra Copies of Chromosome 17

  • On Sunday, December 13, Genomic Health researchers presented results of a large retrospective case-control study assessing the diagnosis of HER2 status, by both fluorescent in situ hybridization (FISH) testing and qua
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SOURCE Genomic Health, Inc.
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