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Genomic Health Announces New Data Reinforcing Clinical Utility of Oncotype DX(R) in Multiple Breast Cancer Populations
Date:12/15/2009

reast cancer specific survival (BCSS) benefit from chemotherapy in either the low (log-rank p=0.56) or intermediate (log-rank p=0.89) Recurrence Score categories; however, chemotherapy resulted in superior BCSS in the high Recurrence Score category (log-rank p=0.033).

Oncotype DX Leads to Fewer Recommendations of Chemotherapy for Women with Node-Positive Breast Cancer

  • A multi-institutional clinical survey presented on Friday, December 11 involving 160 physicians who currently use Oncotype DX in node-positive breast cancer patients found that treatment recommendations frequently changed based on Recurrence Score results, with an overall reduction in chemotherapy treatment recommendations. In the 138 patients with node-positive, hormone receptor-positive breast cancer where the physician had a specific treatment recommendation before obtaining the Oncotype DX Recurrence Score, recommended treatment changed from hormonal therapy plus chemotherapy to hormonal therapy alone in 46 patients (33%), and from hormonal therapy alone to hormonal therapy plus chemotherapy in 13 patients (9%) after obtaining the Recurrence Score.

Oncotype DX Can Be Successfully Performed on Breast Cancer Core Biopsy Samples, Suggesting Potential Role in Neoadjuvant Treatment Planning

  • On Sunday, December 13, researchers presented results from a study examining pathology review and quantitative RT-PCR analysis by Oncotype DX on more than 11,000 core biopsy samples processed at the Genomic Health laboratory between July 15, 2005 and May 31, 2009. Physicians use core needle biopsies to obtain breast cancer tumor tissue without surgery for the purposes of diagnosis. Surgery, adjuvant, and neoadjuvant treatment decisions are based on the analysis of core needle biopsy tissue. The overall Oncotype DX success rate in core biopsy samples was greater than 97 percent, demonstrating that R
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SOURCE Genomic Health, Inc.
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