Navigation Links
Genomas Clinical Study Finds Increased Prevalence of Drug Metabolism Deficiencies in Patients With Serious Psychotropic Side Effects
Date:12/9/2008

Data Support Case for DNA-Guided Medicine in Psychiatry

HARTFORD, Conn., Dec. 9 /PRNewswire/ -- Results from a clinical study published in the current issue of the Future Medicine Group (London) journal Personalized Medicine (Vol. 5, No. 6, pp. 579-587, 2008) are helping to point the way toward the application of DNA-guided medicine to predict psychotropic side effects. The study was conducted at The Institute of Living of Hartford Hospital in collaboration with Genomas.

The CYP2C9, CYP2C19 and CYP2D6 genes from the cytochrome P450 family were chosen for DNA typing because their common variants result in deficient metabolic capacity for many psychotropic drugs. Combinatorial gene analysis revealed that 57 percent of individuals in the psychiatric population were carriers of multiple gene variations associated with no or poor drug metabolism capacity on 2 or 3 genes compared to 36 percent of individuals in the control population. Individuals that are multiply deficient in CYP450 metabolic routes are at risk for developing serious side effects to a variety of psychotropic medications.

"We found clear evidence that there were significantly more innate drug metabolism deficiencies based on the gene variants predominantly observed in the population experiencing side effects," said Gualberto Ruano, M.D., Ph.D., President and CEO of Genomas, and Director of Genetics Research, Hartford Hospital. "Our goal is to enhance patient safety by preventing predictable side effects and at the same time build the case for DNA typing in the optimized utilization of health care resources. We are integrating this clinical experience with development of our PhyzioType Systems for DNA-Guided Medicine."

ABOUT GENOMAS

Genomas(R) Inc. is a biomedical company advancing DNA-guided medicine and personalized healthcare. The company develops revolutionary Phyzio
'/>"/>

SOURCE Genomas Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. EpiCept Reports Expansion of Clinical Development For Licensed Cancer Compound
4. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
5. Romark Initiates Clinical Trial of Alinia(R) for Chronic Hepatitis C in the United States
6. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
7. Millennium Initiates Clinical Trial to EVOLVE the Treatment of Patients with Newly Diagnosed Multiple Myeloma
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. Clinical Trial Effectiveness: How Pharmas & Biotechs Save Cost with Savvy Investigator Management
10. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
11. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2015)... According to a new market research report ... Oximeter), Therapeutic [CPAP, APAP, BPAP, Masks (Full Face Mask), ... Settings, Hospitals) - Analysis & Global Forecasts to 2020", ... Apnea Devices Market for the forecast period of 2015 ... Billion by 2020 from $3.7 Billion in 2015 at ...
(Date:7/29/2015)... , July 29, 2015   KaloBios Pharmaceuticals, Inc ... focused on developing innovative therapies to benefit patients with ... oncology, announced today that the U.S. Food and Drug ... (IND) application for KB003, an anti-GM-CSF monoclonal antibody (mAb), ... the IND is now active. The acceptance ...
(Date:7/29/2015)... July 27, 2015 Research and Markets ( ... "3D Metrology Market by Product (CMM, ODS, and VMM), ... & Geography (North America, Europe, APAC, RoW) - Global ... The 3D metrology market was valued ... grow at a rate of 7.11% during the forecast ...
Breaking Medicine Technology:Sleep Apnea Devices Market Worth $5.3 Billion by 2020 2Sleep Apnea Devices Market Worth $5.3 Billion by 2020 3Sleep Apnea Devices Market Worth $5.3 Billion by 2020 4KaloBios Announces FDA Clearance of Investigational New Drug Application for KB003 in Patients with Chronic Myelomonocytic Leukemia 2KaloBios Announces FDA Clearance of Investigational New Drug Application for KB003 in Patients with Chronic Myelomonocytic Leukemia 3KaloBios Announces FDA Clearance of Investigational New Drug Application for KB003 in Patients with Chronic Myelomonocytic Leukemia 4KaloBios Announces FDA Clearance of Investigational New Drug Application for KB003 in Patients with Chronic Myelomonocytic Leukemia 5Global 3D Metrology Market 2015-2020: Products (CMM, ODS, and VMM) & Applications (Automotive, Aerospace, Energy & Power, Medical and Electronics) 2
... Reportlinker.com announces that a new market research report ... The Outlook for Pharmaceuticals to 2012 ... Pharmaceuticals to 2012 is a new collection of management ... individual and highly-detailed analysis of each market, looking at ...
... announces that a new market research report is available ... http://www.reportlinker.com/p098222/Mammography-World-Markets.html The ... phase of growth fueled by the availability of new ... and the higher interest of individual patients and general ...
Cached Medicine Technology:Reportlinker Adds E7: The Outlook for Pharmaceuticals to 2012 2Reportlinker Adds E7: The Outlook for Pharmaceuticals to 2012 3Reportlinker Adds E7: The Outlook for Pharmaceuticals to 2012 4Reportlinker Adds E7: The Outlook for Pharmaceuticals to 2012 5Reportlinker Adds Mammography World Markets 2
(Date:7/29/2015)... ... ... " Core Organizer ” was featured on NewsWatch as part of its monthly AppWatch, ... iOS, Android, and Windows. Joe Toohey, the host of AppWatch and technology expert, conducted ... organized. , Wouldn’t it be great if everyone could be a little more organized? ...
(Date:7/29/2015)... ... July 29, 2015 , ... More ... and service providers of children living with autism will converge upon Penn State ... demographic. , The National Autism Conference will be held Aug. 3-6 at ...
(Date:7/29/2015)... ... July 29, 2015 , ... According to The Spirits Business ... is directly responsible for stimulating and perpetuating alcohol use disorders. Humans have the same ... of the National academy of Sciences, and has given researchers inklings to explore Rsu1 ...
(Date:7/29/2015)... ... July 29, 2015 , ... ... has once again teamed up with Stillwaters Cancer Support Services and announced a ... Stillwaters provides individual and family counseling, support groups, workshops and educational programs at ...
(Date:7/29/2015)... ... July 29, 2015 , ... Wedding season is in full swing, which means bridal ... pressure of looking good on the big day. Every bride wants to look and feel ... level. , According to a recent study by the American Academy ...
Breaking Medicine News(10 mins):Health News:Get More Organized with the Core Organizer App 2Health News:Penn State Conference to Address Instruction, Success for Children with Autism 2Health News:Study Reveals Potential for Gene Manipulation to Stop Alcohol Addiction 2Health News:Study Reveals Potential for Gene Manipulation to Stop Alcohol Addiction 3Health News:Scott Campbell Agency and Nonprofit Stillwaters Cancer Support Services Initiate New Charity Campaign in Waukesha, WI to Provide Help for People Touched by Cancer 2Health News:Scott Campbell Agency and Nonprofit Stillwaters Cancer Support Services Initiate New Charity Campaign in Waukesha, WI to Provide Help for People Touched by Cancer 3Health News:Say I Do To Surgery: Bridal Beauty On The Rise According to New Survey 2Health News:Say I Do To Surgery: Bridal Beauty On The Rise According to New Survey 3
... By Steven Reinberg HealthDay Reporter , FRIDAY, Jan. ... moratorium on controversial research into a modified avian flu virus ... Although the investigators believe their research has a public ... others that the genetically altered virus could escape from labs ...
... , SATURDAY, Jan. 21 (HealthDay News) -- Talking on ... makes it difficult to walk in a straight line, researchers ... in their 20s whose walking abilities were tested when they ... on a cellphone or texting. The participants, walking ...
... -- More than half (51.4 percent) of American adults at ... new study says. People at risk for hepatitis B ... share needles when using injectable drugs and those who engage ... percent of new hepatitis B infections occur among people with ...
... with gynecologic cancer have new hope in a novel ... University Hospitals (UH) Case Medical Center. A team ... among the first in the nation to launch a ... ovarian, endometrial and select other cancers. Performed immediately ...
... , FRIDAY, Jan. 20 (HealthDay News) -- A new ... during pregnancy and common birth defects. However, the ... defects and mothers with asthma, and potentially with their medication ... was a loss of oxygen from less than well-controlled asthma ...
... Jan. 20 (HealthDay News) -- Job-related injuries and illnesses in ... per year, according to a new study. The figure ... more than the direct and indirect costs of all cancers, ... billion more than the costs of stroke, the researchers say. ...
Cached Medicine News:Health News:Scientists Agree to Delay Controversial Bird Flu Research 2Health News:Scientists Agree to Delay Controversial Bird Flu Research 3Health News:Many U.S. Adults Not Vaccinated for Hepatitis B 2Health News:UH Case Medical Center offers new therapy for gynecologic cancer patients 2Health News:UH Case Medical Center offers new therapy for gynecologic cancer patients 3Health News:Asthma Meds Likely Safe During Pregnancy: Study 2Health News:Asthma Meds Likely Safe During Pregnancy: Study 3Health News:U.S. Work-Related Injuries, Illnesses Take Toll on the Till 2
The DePuy ACE Titanium Active Compression Plate offers ingenuity in the art of fracture management....
Coronet Vacuum Trephine - All metal, ergonomic design and ultra sharp blade with cross hairs....
Corneal Trephine Punch - Stainless steel unit with titanium jaws, complete with PTFE cutting block. 1 reusable unit....
Coronet Donor Punch Set - Unique design providing precise control and full visualization throughout the procedure. Corneal marking pen included....
Medicine Products: