Navigation Links
Genomas Clinical Study Finds Increased Prevalence of Drug Metabolism Deficiencies in Patients With Serious Psychotropic Side Effects
Date:12/9/2008

Data Support Case for DNA-Guided Medicine in Psychiatry

HARTFORD, Conn., Dec. 9 /PRNewswire/ -- Results from a clinical study published in the current issue of the Future Medicine Group (London) journal Personalized Medicine (Vol. 5, No. 6, pp. 579-587, 2008) are helping to point the way toward the application of DNA-guided medicine to predict psychotropic side effects. The study was conducted at The Institute of Living of Hartford Hospital in collaboration with Genomas.

The CYP2C9, CYP2C19 and CYP2D6 genes from the cytochrome P450 family were chosen for DNA typing because their common variants result in deficient metabolic capacity for many psychotropic drugs. Combinatorial gene analysis revealed that 57 percent of individuals in the psychiatric population were carriers of multiple gene variations associated with no or poor drug metabolism capacity on 2 or 3 genes compared to 36 percent of individuals in the control population. Individuals that are multiply deficient in CYP450 metabolic routes are at risk for developing serious side effects to a variety of psychotropic medications.

"We found clear evidence that there were significantly more innate drug metabolism deficiencies based on the gene variants predominantly observed in the population experiencing side effects," said Gualberto Ruano, M.D., Ph.D., President and CEO of Genomas, and Director of Genetics Research, Hartford Hospital. "Our goal is to enhance patient safety by preventing predictable side effects and at the same time build the case for DNA typing in the optimized utilization of health care resources. We are integrating this clinical experience with development of our PhyzioType Systems for DNA-Guided Medicine."

ABOUT GENOMAS

Genomas(R) Inc. is a biomedical company advancing DNA-guided medicine and personalized healthcare. The company develops revolutionary Phyzio
'/>"/>

SOURCE Genomas Inc.
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. EpiCept Reports Expansion of Clinical Development For Licensed Cancer Compound
4. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
5. Romark Initiates Clinical Trial of Alinia(R) for Chronic Hepatitis C in the United States
6. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
7. Millennium Initiates Clinical Trial to EVOLVE the Treatment of Patients with Newly Diagnosed Multiple Myeloma
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. Clinical Trial Effectiveness: How Pharmas & Biotechs Save Cost with Savvy Investigator Management
10. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
11. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)...  Hologic, Inc. (Hologic or the Company) (NASDAQ: ... and supplier of premium diagnostics, medical imaging systems ... the healthcare needs of women, today announced that ... clinical practice comparing breast cancer screening with Hologic,s ... mammography alone showed a significant reduction in recall ...
(Date:5/23/2013)... , May 23, 2013   Direct ... following mastectomy is an appropriate option for many ... to surgically reduce their breast cancer risk, or ... gradual expansion process and a second surgery to ... in the same surgery as mastectomy can be ...
(Date:5/23/2013)... , May 23, 2013  Net Medical Xpress Solutions, ... market, announced today the company has signed a letter ... company based in Huntsville, AL . ... in the staffing and recruitment of telemedicine physicians. Consideration ... the final agreement, which is expected by June 30, ...
Breaking Medicine Technology:First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 2First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 4Direct to Implant ("One Step") Mastectomy Breast Reconstruction Reduces Number of Surgeries and Time to Final Cosmetic Results 2Direct to Implant ("One Step") Mastectomy Breast Reconstruction Reduces Number of Surgeries and Time to Final Cosmetic Results 3Net Medical Xpress Announces Acquisition of Telemedicine Staffing Company 2Net Medical Xpress Announces Acquisition of Telemedicine Staffing Company 3
... with Scripps Florida and Scripps Research in La ... ... FRANCISCO, Calif., and LA JOLLA, Calif., May 14 /PRNewswire-,FirstCall/ -- Poniard ... and The Scripps Research,Institute, a non-profit biomedical research organization, today announced,that ...
... DOYLESTOWN, Pa., May 14 The Quigley,Corporation (Nasdaq: ... study,conducted by its wholly owned subsidiary, Quigley Pharma ... anti-viral activity of its compound,QR448(a). The compound was ... Bronchitis Virus (IBV). The data from the study ...
Cached Medicine Technology:Poniard Pharmaceuticals Licenses Kinase Inhibitors From The Scripps Research Institute 2Poniard Pharmaceuticals Licenses Kinase Inhibitors From The Scripps Research Institute 3Poniard Pharmaceuticals Licenses Kinase Inhibitors From The Scripps Research Institute 4Quigley Announces Successful Poultry Study of Chickens With Infectious Bronchitis; Plans to Approach the Poultry Industry for Potential Commercialization 2Quigley Announces Successful Poultry Study of Chickens With Infectious Bronchitis; Plans to Approach the Poultry Industry for Potential Commercialization 3Quigley Announces Successful Poultry Study of Chickens With Infectious Bronchitis; Plans to Approach the Poultry Industry for Potential Commercialization 4Quigley Announces Successful Poultry Study of Chickens With Infectious Bronchitis; Plans to Approach the Poultry Industry for Potential Commercialization 5
(Date:5/24/2013)... (PRWEB) May 24, 2013 Let’s face it: ... is not uncommon for the majority of people to be ... is due to a coffee addiction or simply genetics, yellowish ... procedures are so popular. , Herald Square Dental ... very effective whitening system: Venus White Max. , Teeth ...
(Date:5/24/2013)... 24, 2013 Area homeowners dreaming about owning ... hot tubs to choose from at factory-direct pricing during the ... sales event takes place at Emerald Pool and Patio ... , Jacuzzi, the industry's leading hot tub brand, scheduled the ... country. The event will feature popular hot tub models at ...
(Date:5/24/2013)... New York (PRWEB) May 24, 2013 ... lawsuit involving Intuitive Surgical Inc.’s da Vinci Surgical ... to court records, a Washington State Court jury ruled ... negligence in training a surgeon who performed a da ... later. The patient’s family had alleged in their ...
(Date:5/24/2013)... mutations central to the development of infantile myofibromatosis (IM)a ... and soft tissuemay provide new therapeutic targets, according to ... Sinai. The findings, published in the American Journal ... options for this debilitating disease, for which the only ... tumors. , IM is an inheritied disorder that develops ...
(Date:5/24/2013)... 2013 BestSatelliteProviders.com the online satellite ... of consumers compare the features and services offered ... recently released the rankings of the best ... for viewing on their website. , ... to Adam Matthews, the spokesperson for BestSatelliteProviders.com, “When ...
Breaking Medicine News(10 mins):Health News:Herald Square Dental Introduces New In-office Whitening System: Venus White Max 2Health News:Truckload of Jacuzzi® Hot Tubs Rolls into Bend, Oregon on May 24, 2013 for Sales Event 2Health News:Da Vinci Robot Lawsuit News: Bernstein Liebhard LLP Comments on Verdict in Nation’s First Trial Involving Alleged Da Vinci Complications 2Health News:Da Vinci Robot Lawsuit News: Bernstein Liebhard LLP Comments on Verdict in Nation’s First Trial Involving Alleged Da Vinci Complications 3Health News:Researchers identify first drug targets in childhood genetic tumor disorder 2Health News:Best Rural Internet Service Provider in 2013 by BestSatelliteProviders.com 2
... therapy may encourage prostate cancer cells to produce a ... the body, a new study by Johns Hopkins researchers ... to changes in this standard treatment for a sometimes ... discovery is far too preliminary for prostate cancer patients ...
... well as slight changes in eating behavior, could explain ... narcolepsy, according to a study published in the October ... authored by Dorothe Chabas, MD, PhD, of the Fdration ... on 13 patients with narcolepsy and nine healthy controls ...
... studies that have indicated the speed with which adolescents can ... Medical School have conducted the first study to determine why ... not. , We know that nicotine can have an ... that not every adolescent who tries a cigarette gets hooked, ...
... in mice that surgeons and cardiologists may be able ... , The research, published in the October issue of ... the British Heart Foundation and conducted by Saadeh Suleiman, ... and his colleagues at the Bristol Heart Institute. It ...
... suggestion questioned by experts , , SUNDAY, Sept. 30 (HealthDay ... more likely to visit emergency rooms or be hospitalized ... the finding of a new study that reaches the ... may underlie these racial disparities." , However, that genetics ...
... to not stop statin drug use , , ... disease should not stop taking cholesterol-lowering drugs before any ... this week by the American Heart Association and the ... update those published in 2002, provide a framework for ...
Cached Medicine News:Health News:Standard treatment for prostate cancer may encourage spread of disease 2Health News:Lower metabolism, eating behavior possibly explain the cause of overweight in narcolepsy 2Health News:Initial reaction to nicotine can dictate addiction 2Health News:New research suggests hearts are experts at self-preservation 2Health News:Do Blacks Have Genetic Weakness to Asthma? 2Health News:Take Care of Heart Before Any Surgery: Experts 2
Compact tray features all components for urethral catheterization....
Inquire...
Provides maximum comfort upon insertion through ultra-smooth catheter eyelets--formed with advanced ultrasonic technology....
... immunoassay for the quantification of NT-proBNP in ... Elecsys proBNP assay helps to rule-out efficiently ... also indicate the severity of the disease ... addition, NT-proBNP facilitates monitoring, allowing for the ...
Medicine Products: