Navigation Links
Genocea Reports Positive Initial Phase 1/2a Results for GEN-003, its Pioneering Therapeutic Vaccine Candidate for the Treatment of Herpes Simplex Virus-2 (HSV-2), at ICAAC 2013
Date:9/12/2013

ory Medicine, University of Washington, Member, Fred Hutchinson Cancer Research Center. "The ability to reduce viral shedding is critical, as that is the main driver of transmission of HSV-2 to sexual partners and newborns."

"These initial results are unprecedented in the clinical development of vaccines for HSV-2. We are proud to be pioneers in the field of T cell-directed vaccines. We believe these results validate the potential of our unique ATLAS™ platform to discover and develop vaccines for unmet medical needs," noted Chip Clark, President and Chief Executive Officer of Genocea. "We will complete this study and continue clinical development of GEN-003 with urgency, in order to bring this promising treatment to this large patient population that is in dire need of an approved vaccine that can prevent or treat their disease."

About the Clinical Trial  
The ongoing study is a double-blind, placebo-controlled dose escalation Phase 1/2a clinical trial to evaluate the safety and immunogenicity of GEN-003. The study enrolled 143 volunteers with a history of moderate-to-severe recurrent HSV-2 infection at seven clinics in the U.S. Patients were sequentially enrolled into one of three dose cohorts (10, 30 or 100 ug of each protein) and randomized within cohorts to receive either GEN-003, vaccine antigens without adjuvant or placebo. Patients received three injections of the assigned treatment into an arm muscle at 21 day intervals. Antibody (B cell) and T cell immune responses to the two protein antigens contained in the vaccine were measured. Safety was monitored by an independent Data Safety Monitoring Committee. A secondary objective of the study was to compare the quantitative presence of HSV-2 ("shedding") before and after the treatments. Viral shedding is considered an important marker for risk of recurrence and transmission of infection.  For more information about this clinical study of GEN-
'/>"/>

SOURCE Genocea Biosciences Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Genocea Biosciences Selected To Present Late-Breaking Oral Presentation At ICAAC 2013
2. Genocea Publishes Preclinical Data For Investigational Vaccine Candidate For HSV-2
3. Industry Veteran Katrine Bosley Joins Genocea Biosciences Board Of Directors
4. Omeros Reports Additional Positive Results from OMS824 Program
5. S&P Capital IQ Initiates Coverage on Epigenomics AG in Standard & Poors Factual Stock Reports
6. CorMedix Reports Receipt of European Patent Office Decision to Allow Prosl Patent to Proceed in European Union
7. Market Research Reports: Biologics, Biosimilars, Bioseparation Systems for Biopharmaceutical Markets
8. South East Asia Medical Device Market Reports
9. CIVETS Medical Device Market Reports
10. Central Europe and Baltic States Medical Device Market Reports
11. Northen Europe Medical Device Market Reports
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... , Oct. 20, 2014  AnaptysBio, Inc., ... therapeutic antibodies, today announced the appointment of ... Dr. Londei will lead the preclinical and clinical ... "We are pleased to welcome Dr. Londei ... Suria , President and Chief Executive Officer of ...
(Date:10/20/2014)... 20, 2014   Mary,s Medicinals today announced ... a 4-Star Sponsor of Operation Grow4Vets , a ... products, programs and services to assist them in living ... Key Facts: , An ever-increasing number of ... and effective treatment for pain, Post-traumatic Stress Disorder (PTSD) ...
(Date:10/19/2014)... SEATTLE, Wash. , Oct. 20, 2014 ... today that it will report its third quarter 2014 ... close of the U.S. financial markets. Following the announcement, ... conference call to discuss the results and provide a ... PDT). Access to the event can be obtained as ...
Breaking Medicine Technology:AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2Mary's Medicinals Announces 4-Star Sponsorship of Operation Grow4Vets 2Mary's Medicinals Announces 4-Star Sponsorship of Operation Grow4Vets 3CTI BioPharma to Report Third Quarter 2014 Financial Results on October 29, 2014 2
(Date:10/20/2014)... Pittsburgh, PA (PRWEB) October 20, 2014 ... new, minimally-invasive procedure that enables physicians to repair a ... , The MitraClip system, developed by ... regurgitation (MR), a progressive and life-threatening condition in which ... allowing blood to flow backward from the heart’s left ...
(Date:10/20/2014)... 2014 T.E.N., a technology and ... today that William H. Murray, renowned author and ... Luminary Leadership Award winner. Presented annually, the ISE® ... outstanding leader and industry practitioner for his or ... the information security industry. , Formerly with IBM, ...
(Date:10/20/2014)... 2014 My Clients Plus ( http://www.MyClientsPlus.com ... The new module enables easy administration and routing ... quality care. , This application allows users such as ... attach a to-do item to a specific client, categorize ... up reoccurring reminders for follow-ups. It's designed to ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Rockynol ... Living Center on Oct. 14. The $11 million project ... services, and a cooked-to-order kitchen with full-service restaurant style ... premier choice for first class Assisted Living apartments,” said ... residents deserve the highest quality of care and this ...
(Date:10/20/2014)... Final Cut Pro X Plugin developers from Pixel Film ... FCPX filmmakers . , “Fun, cool, and simple are ... Says Christina Austin, CEO of Pixel Film Studios. “It has ... comes with all the tools needed for a full ... added style, a title screen for an introduction, two lower ...
Breaking Medicine News(10 mins):Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 2Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 4Health News:My Clients Plus Announces New Workflow Management Software 2Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Today Pixel Film Studios Announced the Release of the Citrus theme for Final Cut Pro X 2
... ... Pole Fitness, Women’s Answer to a Male Dominated Gym scene. Embody Pole gives the women ... ... notion of physical fitness were completely male-centered. Where do women go when they want to ...
... for spike between 2008 and 2009, analysis finds , ... injuries appear to be on the rise, warns the ... sports and baseball/softball are the main culprits. , The ... trends as they transpired between 2008 and 2009, based ...
... disease remission in patients with rheumatoid arthritis (RA) ... including work productivity and quality of life according ... Annual Congress of the European League Against Rheumatism ... reported in addition to improvements in measures of ...
... drinkers were 39% less likely to get these malignancies ... help protect against head and neck cancers, a new ... the International Head and Neck Cancer Epidemiology consortium. They ... a day) were 39 percent less likely to develop ...
... cost of brain-tumor surgery might both be reduced if surgery ... procedure, according to a new study conducted at The Ohio ... Richard J. Solove Research Institute. The study, published online June ... outcomes of 39 patients treated for glioma, a type of ...
... being a good dad, expert suggests , FRIDAY, June 18 ... new ties and other tokens of gratitude, they might think ... a promise that they,ll watch their health, suggests a family ... die younger than women and are more likely to die ...
Cached Medicine News:Health News:“Embody Pole Fitness” Puts a Sexy Spin on Fitness in the Inland Empire 2Health News:Bump in Head Injury Numbers Linked to Summer Play 2Health News:Targeting disease remission has socio-economic benefits over low disease activity 2Health News:Targeting disease remission has socio-economic benefits over low disease activity 3Health News:Awake sedation for brain surgery may shorten hospital stay 2Health News:On Father's Day, Give Dad Gift of Health 2
... a patented Per-fit™ flexible PVC tube with ... cuff specifically designed to reduce insertion force ... anatomy. The kit s unique obturator/dilator design ... allowing for an easier transition through the ...
... Per-fit™ flexible PVC tube with a tapered ... designed to reduce insertion force and more ... kit s unique obturator/dilator design is engineered ... an easier transition through the tissue into ...
... Self-contained kits provide convenience and cost ... tracheostomy care trays offer a variety of ... and management of the tracheostomized patient. , ... trays, and trays with disposable inner cannula ...
... and cost control. , ,Our full ... variety of wound dressing components for the ... patient. , ,Tray configurations include full ... inner cannula for both rigid and flexible ...
Medicine Products: