Navigation Links
Genocea Reports Positive Initial Phase 1/2a Results for GEN-003, its Pioneering Therapeutic Vaccine Candidate for the Treatment of Herpes Simplex Virus-2 (HSV-2), at ICAAC 2013
Date:9/12/2013

CAMBRIDGE, Mass., Sept. 12, 2013 /PRNewswire/ -- Genocea Biosciences Inc., a clinical-stage biopharmaceutical company developing T cell vaccines to prevent and treat infectious diseases, reported today positive results from a planned analysis of a Phase 1/2a clinical study of its lead candidate, GEN-003, a first-in-class investigational protein subunit vaccine to treat patients with recurrent outbreaks of genital herpes simplex virus type 2 (HSV-2) infection. The data, presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2013), show that patients who received three doses of GEN-003 had reductions in the frequency of viral shedding of up to 51 percent (p<0.001). By contrast, those who received a placebo had no decline in viral shedding. T cell immune responses, believed to be important for the control of HSV-2 infection, increased more than twentyfold to one vaccine antigen (ICP4) and more than tenfold to the other (gD2). In addition, GEN-003 increased neutralizing antibodies to the HSV-2 virus fivefold, on average, compared to baseline values. GEN-003 was well tolerated overall.

Results from an exploratory analysis also suggest that the interval between the first immunization and the next recurrence of genital herpes may be prolonged in patients who received GEN-003 compared to those who received placebo, though this first-in-human clinical trial was not designed to test whether GEN-003 improves symptoms or reduces the frequency of recurrent disease.

"These are the first data that provide compelling evidence that a vaccine administered to people with genital herpes can affect their infection. We are excited that GEN-003 reduced viral shedding as this finding paves the way for future trials that will measure the impact on clinical outbreaks," said Anna Wald, MD, MPH, Principal Investigator of the study and Professor of Medicine, Epidemiology and Laborat
'/>"/>

SOURCE Genocea Biosciences Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Genocea Biosciences Selected To Present Late-Breaking Oral Presentation At ICAAC 2013
2. Genocea Publishes Preclinical Data For Investigational Vaccine Candidate For HSV-2
3. Industry Veteran Katrine Bosley Joins Genocea Biosciences Board Of Directors
4. Omeros Reports Additional Positive Results from OMS824 Program
5. S&P Capital IQ Initiates Coverage on Epigenomics AG in Standard & Poors Factual Stock Reports
6. CorMedix Reports Receipt of European Patent Office Decision to Allow Prosl Patent to Proceed in European Union
7. Market Research Reports: Biologics, Biosimilars, Bioseparation Systems for Biopharmaceutical Markets
8. South East Asia Medical Device Market Reports
9. CIVETS Medical Device Market Reports
10. Central Europe and Baltic States Medical Device Market Reports
11. Northen Europe Medical Device Market Reports
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... -- Bronstein, Gewirtz & Grossman, LLC is investigating potential ... Celladon Corporation ("Celladon" or the "Company") (NasdaqGM: CLDN -News).  ... or his investor relations coordinator Eitan Kimelman ... The investigation concerns whether Celladon and certain of its ... of the Securities Exchange Act of 1934.  ...
(Date:4/27/2015)... 2015 Vermillion, Inc. (VRML), a ... announced today it will report first quarter ... on Monday, May 11, 2015, followed by ... 4:30pm Eastern.Conference Call & Webcast: Monday, May ... , 888-556-4997International: , 719-457-2628Conference ID: , ...
(Date:4/27/2015)... Pa. , April 27, 2015  Novira Therapeutics, ... therapies for curative treatment of chronic hepatitis B virus ... data for its lead HBV core inhibitor candidate, NVR ... Association for the Study of the Liver (EASL) in ... antiviral activity of NVR 3-778 from studies performed in ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Bronstein, Gewirtz & Grossman, LLC Announces Investigation of Celladon Corporation 2Novira Therapeutics Announces Presentation of Preclinical Antiviral Data for NVR 3-778 at EASL 2Novira Therapeutics Announces Presentation of Preclinical Antiviral Data for NVR 3-778 at EASL 3
... SAN DIEGO, May 3, 2012  Gen-Probe Incorporated (NASDAQ: ... the following three upcoming investor conferences previously announced on April ... of these investor conferences: , Deutsche Bank 37th ... 1:30 p.m. Eastern Time;  , Baird,s 2012 Growth Stock ...
... International, Inc. (Pii), a contract development and manufacturing organization ... announced today that it has made a grant to ... utilized to support pharmaceutical education for graduate students, as ... hot melt extrusion and other pharmaceutical processing technologies. ...
Cached Medicine Technology:Gen-Probe Withdraws from Previously Announced Investor Presentations 2Pharmaceutics International, Inc. (Pii) Supports University Pharmaceutical Technology Education and Research 2Pharmaceutics International, Inc. (Pii) Supports University Pharmaceutical Technology Education and Research 3
(Date:4/27/2015)... Jackson, Tennessee (PRWEB) April 27, 2015 A ... to help young people trapped in substance abuse. Programming for ... which will serve girls, is launching this summer. , The ... more than $100,000 to serve adolescents. The Youth Town Jim ... in Collierville on Monday, May 4, with tee times at ...
(Date:4/27/2015)... MD (PRWEB) April 27, 2015 Jesse ... the 2015–2020 United States Pharmacopeial Convention (USP) at the ... is Professor of Medicine at Georgetown University and the ... and Stewardship (COMPASS). , As USP President, a volunteer ... Convention Meeting. He will be a voting member, ex ...
(Date:4/27/2015)... UC Davis investigators have settled a ... inherited disorder that historically affected Ashkenazi Jews from ... populations of Semitic descent, particularly families from Saudi ... the researchers uncovered the biochemical underpinnings of Canavan ... incurable and progressively fatal neurological condition. The UC ...
(Date:4/27/2015)... Based in the Twin Cities of Minneapolis and ... insurance marketing organizations in the country focused on delivering ... as well as employer sponsored ancillary benefits. Spending two ... opportunity to consult with disability insurance carriers, helping to ... , An example of these programs include the most ...
(Date:4/27/2015)... (PRWEB) April 27, 2015 On April 16, ... Get Rid of Stretch Marks ,” interviewed a UK ... . Stretch marks are a type of scar ... are caused by a breakdown of the elsastin and collagen ... (see: goo.gl/iRdmEe) , “Stretch mark removal with the Coolbeam ...
Breaking Medicine News(10 mins):Health News:Golf, Sermon on the Mount and More to Support Youth Town’s Jericho and Eden Programs 2Health News:Dr. Jesse Goodman Elected President of the USP Convention 2Health News:UC Davis Makes Breakthrough in Understanding Canavan Disease 2Health News:UC Davis Makes Breakthrough in Understanding Canavan Disease 3Health News:UC Davis Makes Breakthrough in Understanding Canavan Disease 4Health News:Simplified Solutions Now Makes Disability Insurance Business With Secura Consultants Even Easier! 2Health News:Stretch Marks: The Latest Treatment Options for Stretch Mark Removal 2
... Inc.,(Nasdaq: NXTM ), a leading manufacturer of innovative ... its common stock and,warrants. The private placement consists of ... of $4.50 per share and warrants to purchase 1.9,million ... $5.50 per share,which price may be adjusted to $3.00 ...
... /Xinhua-PRNewswire-FirstCall/ -- Linkwell,Corporation (Linkwell) (OTC Bulletin Board: ... healthcare related disinfectants in China,announced today that ... of China,s,earthquake relief efforts. The Chinese government, ... on an,unprecedented scale in response to the ...
... May 23 Kellogg Company today,announced a $250,000 donation ... efforts in the Sichuan province in southwestern China.,The contribution ... be designated to support the efforts of the Red ... work ahead as people mobilize to rebuild their lives,and ...
... Center (MUMC) now offers a type of gallbladder ... belly button. It,s called single,incision laparoscopic surgery, or ... the SILS technique. One of them is Christopher ... the gallbladder through a,1cm. incision in the belly ...
... from the Peninsula Medical School in Cornwall, UK, have ... topically applied cream with visible light to destroy cancer ... is applied directly to skin cancers and pre-cancers, which ... red light is then shone on the tumour a ...
... Honor, books and DVDs to local schools, SAN ... Medal of Honor Foundation donated 5,000 copies of the,best-selling ... Call of,Duty," to California schools., The book chronicles ... nearly 20 from California, who hold our nation,s,highest award ...
Cached Medicine News:Health News:NxStage Announces $43 Million Private Placement of Equity Securities 2Health News:NxStage Announces $43 Million Private Placement of Equity Securities 3Health News:NxStage Announces $43 Million Private Placement of Equity Securities 4Health News:Linkwell Corporation Runs 24/7 Disinfectant Operations to Support China's Earthquake Relief Efforts 2Health News:Linkwell Corporation Runs 24/7 Disinfectant Operations to Support China's Earthquake Relief Efforts 3Health News:SILS Surgical Technique Now Available at MUMC 2Health News:Let there be light 2Health News:Let there be light 3Health News:TriWest Teaches California Kids About Veteran's Sacrifice, Courage 2
Designed to be removed from under surgical gown without compromising sterile fields. Two straps criss-cross in the back and attach with velcro in the front....
Our 'flex' removes the apron weight from the shoulders while providing back support. Unlike other elastic backs, ours does not wrinkle up, making cleaning easier....
Front protection with choice of adjustable 2" buckle or velcro belt which crosses the back for a comfortable fit. Adjustable straps at shoulders keeps apron snug....
This battery-powered, single-use pulsed stimulator delivers approximately 0.7mA at 80 pulses per second and uses a subdermal needle as the grounding (anode) electrode. A "current flow" confirmation l...
Medicine Products: