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Genocea Publishes Preclinical Data For Investigational Vaccine Candidate For HSV-2
Date:3/18/2013

CAMBRIDGE, Mass., March 18, 2013 /PRNewswire/ -- Genocea Biosciences Inc., a clinical-stage company pioneering novel T cell vaccines, announced today the publication of new data to support GEN-003, its investigational vaccine for the treatment of HSV-2. The results, which are available today in the print edition of Journal of Virology, show that vaccination with GEN-003, along with Matrix-M™ adjuvant, induced antigen- and virus-specific immune responses and improved outcomes in preclinical models of the disease. This is the first HSV-2 therapeutic vaccine to show a significant impact on viral shedding after the completion of the dosing regimen in preclinical models.  Genocea has fully enrolled its Phase 1/2a study of GEN-003 and expects to report preliminary data in the second half of 2013.

"These results provide strong support for our ongoing clinical investigation of GEN-003, and provide further validation of our approach for identifying promising, next-generation vaccine candidates capable of preventing and treating a wide variety of complex pathogens," said Chip Clark , CEO of Genocea.

The antigens were identified using ATLAS™, Genocea's platform for the rapid discovery of antigens that induce T cell immunity. In addition to HSV-2, Genocea is utilizing this technology to develop preventive and therapeutic vaccines for Chlamydia, malaria, and Pneumococcus. The company anticipates beginning clinical trials in late 2013 for GEN-004, a vaccine candidate to prevent infections caused by Streptococcus pneumoniae.   

About GEN-003
GEN-003 is a first-in-class, protein subunit, therapeutic T cell vaccine intended to reduce recurrence and transmission of Herpes Simplex Virus type 2 (HSV-2).  GEN-003 includes the antigens ICP4 and gD2, as well as the proprietary adjuvant Matrix-M™, licensed from Isconova AB.  The adjuvant is a novel,
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SOURCE Genocea Biosciences Inc.
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