Navigation Links
Genmab Announces Upcoming Ofatumumab Studies
Date:8/25/2008

Front Line CLL, NHL and CLL Retreatment and Japanese Development Studies

Planned

COPENHAGEN, Denmark, August 25 /PRNewswire-FirstCall/ -- Genmab has announced plans to begin four studies of ofatumumab in chronic lymphocytic leukemia and non-Hodgkin's lymphoma.

Genmab A/S (OMX: GEN) announced today plans to begin four studies of ofatumumab in chronic lymphocytic leukemia (CLL) and follicular non-Hodgkin's lymphoma (NHL) this year.

"Genmab and GSK have worked diligently to expand the ofatumumab development program to maximize the value of the antibody for patients and shareholders since our collaboration began," said Lisa N. Drakeman, Ph.D., Chief Executive Officer of Genmab."The new studies we are initiating this year will examine the potential of ofatumumab in Japan as well as a number of new treatment settings - retreatment, maintenance and front line with chlorambucil."

Phase III CLL front line chlorambucil combination This open-label, parallel-arm study will include 444 patients with previously untreated CLL.Patients in the study will be randomized to receive ofatumumab in combination with chlorambucil or chlorambucil alone.Patients receiving ofatumumab in combination with chlorambucil will receive one infusion of ofatumumab at 300 mg, one infusion at 1000 mg a week later, followed by up to 11 monthly infusions at 1000 mg.Patients will be evaluated for disease status one month following last treatment then every 3 months for 5 years.

The primary objective of the study is to evaluate the progression free survival of ofatumumab in combination with chlorambucil therapy versus chlorambucil therapy alone for the treatment of front line CLL.

Phase II CLL ofatumumab retreatment and maintenance treatment study This study will examine the retreatment and maintenance treatment of refractory CLL patients who participated in the ongoing Phase III CLL study and had disease progression following
'/>"/>

SOURCE Genmab A/S
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. DAHANCA Initiates Head and Neck Cancer Study With Genmabs HuMax-EGFr
2. Bionomics Achieves US$1 Million Milestone Payment from Genmab
3. Genmab A/S - Company Announcement: Novel Insights into HuMax-EGFr Mechanisms of Action Published in PNAS
4. Genmab Announces Updates on Phase III Cancer Studies
5. Genmab A/S - Company Announcement Ofatumumab in Subcutaneous Study in Rheumatoid Arthritis Summary: Subcutaneous Administration of Ofatumumab Investigated in Phase I/II Study
6. Genmab Initiates Study of Zalutumumab With Radiotherapy in Head and Neck Cancer
7. Genmab Reaches Milestone in Ofatumumab Collaboration
8. Genmab A/S - Company Announcement: Recruitment Completed In Ofatumumab CLL Front Line Study
9. Genmab and GlaxoSmithKline Announce Positive Top-Line Results in Ofatumumab Chronic Lymphocytic Leukemia Pivotal Study
10. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
11. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... Ohio , Jan. 15, 2014  A novel wearable injector ... easy and painless for patients to self-inject prescription drugs in ... disorders, including cancer, blood diseases, autoimmune deficiencies, and genetic disorders.  ... to grow to $220B by 2018, according to analysts.   Many ...
(Date:1/14/2014)... AUSTIN, Texas , Jan. 14, 2014  Luminex Corporation (Nasdaq: ... report results for the fourth quarter of 2013 on Monday, ... scheduled for release after the close of trading. ... a conference call to discuss the operating highlights and financial ...
(Date:1/14/2014)... Calif. , Jan. 14, 2014 The Brandeis Medical Center, ... Angeles a premier and affordable laser tattoo removal experience ... Dr. Brandeis, focus is in providing high quality cosmetic services with ... patients. " Southern California has seen ...
Breaking Medicine Technology:Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2
... 2011 Omeros Corporation (Nasdaq: OMER ) today ... Regents of the University of California to a new series ... advance in the control of surgical and traumatic bleeding. ... represents a potential life-saving treatment for patients. With the withdrawal ...
... 5, 2011 CutisPharma, Inc. announced the introduction ... Mary,s Mouthwash compounding kits. These products complete the ... line already includes FIRST® - Mouthwash BLM, and ... FIRST® - Duke,s Mouthwash are comparable to those ...
Cached Medicine Technology:Omeros Licenses Novel Antifibrinolytic Agents 2Omeros Licenses Novel Antifibrinolytic Agents 3Omeros Licenses Novel Antifibrinolytic Agents 4CutisPharma Launches New Prescription Mouthwash Kits Expanding Product Line 2
(Date:4/17/2014)... genetic variant specifically associated with the risk of ... per cent of all breast cancer cases. , ... sub-type, called invasive lobular carcinoma, gives researchers important ... kind of breast cancer, which can be missed ... in the journal PloS Genetics , was ...
(Date:4/17/2014)... Biology and Medicine a multidisciplinary research team ... in the Institute of Genomic Biology (IGB) on ... describe their recent work on subcellular redox homeostasis. ... functions including energy metabolism, signaling, and transcriptional processes. ... cellular behavior, redox status has been recognized as ...
(Date:4/17/2014)... Jon McCullers, MD, was recently invited to submit ... Nature Reviews Microbiology , one of the world,s ... infectious disease specialist, and chair of the Department ... Science Center, analyzed the epidemiology and microbiology of ... as well as more recent 2009 novel H1N1 ...
(Date:4/17/2014)... as 10 million older Americans suffer from depression, often ... However, new research a project that followed the ... years found that Internet use among the elderly ... 30 percent. , "That,s a very strong effect," said ... information studies and media who led the project. "And ...
(Date:4/17/2014)... School of Medicine (BUSM) have discovered that the ... experimental model. The findings, reported in the ... may lead to more effective treatments for alcoholism. ... the leading causes of illness and death in ... by limiting the productivity of workers and necessitating ...
Breaking Medicine News(10 mins):Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:Internet use can help ward off depression among elderly 2Health News:BUSM researchers find anti-seizure drug may reduce alcohol consumption 2
... Scholars Program has granted 11 geriatric social work researchers ... support for projects that will improve healthy outcomes for the ... year is a partnership with the Veterans Health Administration ... are PhD-level social workers from the VA who will be ...
... Survival rates of wealthier patients and those younger than ... brain tumor, have improved since 2000, whereas rates for ... have remained stagnant, according to an abstract being presented ... in Chicago by Thomas Jefferson University Hospital researchers on ...
... Faculty of Medicine & Dentistry are trying to reverse ... of the top two killers in Canada. , ... University of Alberta and Edie Pituskin, a registered nurse ... are starting what is called the MANTICORE clinical trials. ...
... HealthDay Reporter , THURSDAY, June 2 (HealthDay News) -- Although ... to powerful medications more HIV-infected Americans are living longer and ... close of 2008 there were 1,178,350 people in the United ... they are infected, according to researchers from the U.S. Centers ...
... University of Louisville researchers are one step closer ... longer work because of disease or damage from treatment ... Darling, PhD, professor, Department of Oral Health and Rehabilitation, ... protein sorting mechanism used by the salivary gland. The ...
... as hepatitis C (HCV) are typically recommended for liver ... patients who question whether less invasive testing is available, ... serum markers are two such diagnostic options reviewed in ... Hepatology , a journal of the American Association for ...
Cached Medicine News:Health News:Hartford Program issues geriatric social work awards, forms VA partnership 2Health News:Hartford Program issues geriatric social work awards, forms VA partnership 3Health News:ASCO: Glioblastoma in the 21st century: Wealthier patients living longer than poorer patients 2Health News:U of Alberta researchers hoping to stop heart disease in cancer patients before it starts 2Health News:More Than 1 Million Americans Now Living With HIV: CDC 2Health News:More Than 1 Million Americans Now Living With HIV: CDC 3Health News:UofL researchers uncover mechanism in saliva production 2Health News:Noninvasive diagnostics may offer alternative to liver biopsy for assessing liver fibrosis 2
... PLUS pachometers are acknowledged to be the ... pachometers available. These benefits are due to ... and smallest tip footprint available coupled with ... for every displayed reading. Thus corneal thickness ...
... versatile and uncomplicated use of the Leica ... obtained make it the instrument of choice ... cryostat applications. The open top stainless steel ... accessible and offers ample space for convenient ...
... the new style of Bright cryostat. ... OTF/AS cryostat, the new OTF5000 incorporates ... ever-reliable and powerful 5040 microtome. A ... package deals makes the range of ...
... The Leica TP1020 product family are ... a perfect combination of approved technology with ... processing and maximum safety for tissues at ... engineering design based on proven precision mechanics ...
Medicine Products: