Navigation Links
Genmab A/S - Company Announcement: Novel Insights into HuMax-EGFr Mechanisms of Action Published in PNAS
Date:4/15/2008

COPENHAGEN, April 15 /PRNewswire-FirstCall/ -- Summary: Genmab has announced that HuMax-EGFr (zalutumumab) inhibits epidermal growth factor receptor signaling by locking epidermal growth factor receptor (EGFr) molecules into a very compact, inactive conformation. The flexibility of the EGFr is central to its role in signaling, and binding of HuMax-EGFr (zalutumumab) results in effective inhibition of cancer cell growth.

Genmab A/S (OMX: GEN) announced today new insights showing that HuMax-EGFr(TM) (zalutumumab) locks epidermal growth factor receptor (EGFr) molecules into a very compact, inactive conformation. The flexibility of the EGFr is central to its role in signaling, and binding of HuMax-EGFr (zalutumumab) results in effective inhibition of cancer cell growth.

As EGFr activity plays an important role in many cancers, targeting it with HuMax-EGFr (zalutumumab) should make it especially difficult for cancer cells to grow, multiply, and survive.

By using an electron microscope based technique, called protein tomography, the structural rearrangement accompanying inhibition of individual EGFr molecules was studied. Biochemical analyses showed that HuMax-EGFr binds bivalently to the EGFr and, furthermore, was shown to prevent receptor dimerization and to severely limit intermolecular flexibility of EGFr molecules.

"These new insights point out that HuMax-EGFr may employ at least three distinct mechanisms of action leading to inhibition of cancer cell growth. HuMax-EGFr is able to induce potent immune system defense activity known as ADCC, block growth factor binding to EGF receptors, and we now established that HuMax-EGFr inhibits EGFR activation by limiting receptor flexibility. This new data further underlines the potential of HuMax-EGFr for treatment of solid cancers." said Lisa N. Drakeman, Ph.D., Chief Executive Officer of Genmab.

These new findings will be published in the journal Proceedings of the National Academy of
'/>"/>

SOURCE Genmab A/S
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. DAHANCA Initiates Head and Neck Cancer Study With Genmabs HuMax-EGFr
2. Bionomics Achieves US$1 Million Milestone Payment from Genmab
3. New Company Starts, Bridging the Development Gap in the Discovery of Cancer Drugs
4. The Female Health Company Receives USAID DELIVER PROJECT Order for 5 Million Units
5. Niaid / Barda Awards Elusys a $12 Million Contract to Further Develop Anthim, the Companys Anthrax Therapeutic
6. Nastech Pharmaceutical Company Announces Initiation of Phase 2 Clinical Trial for Insulin Nasal Spray to Treat Diabetes
7. Nastech Pharmaceutical Company Announces Initiation of Phase 2 Clinical Trial for PYY3-36 Nasal Spray to Treat Obesity
8. Keryx Biopharmaceuticals to Present at William Blair & Company Small-Cap Growth Stock Conference
9. Female Health Company Receives Brazilian Order: Four Million FC Female Condoms
10. The Pittsburgh Life Sciences Greenhouse Relocates Therapeutics Company to Pittsburgh
11. Chimerix Initiates a Multi-dose Clinical Trial of the Companys Lead Compound, CMX001, for the Treatment for Smallpox Infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Dec. 18, 2014 Research and Markets ... of the "Micro Market Monitor: North American ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... progressing steadily, which has resulted in fueling the ... The main purpose of these dermatology devices is ...
(Date:12/19/2014)... Calif., Dec. 18, 2014 Capnia, Inc. ... development of medical diagnostics based on its proprietary ... flow, today announced financial results for the third ... "Following the completion of our initial ... to maximize the recently initiated CoSense® commercial launch," ...
(Date:12/19/2014)... 18, 2014 Since last month,s FBI shutdown ... known as the leading online black market for illegal ... in its offering of drugs and other illegal items.  ... takedowns did succeed in lowering the numbers of drugs ... the markets in August. But some new sites that ...
Breaking Medicine Technology:Micro Market Monitor: North American Dermatology Diagnostic Devices Market 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 3Capnia Reports Third Quarter 2014 Financial Results 2Capnia Reports Third Quarter 2014 Financial Results 3Capnia Reports Third Quarter 2014 Financial Results 4Capnia Reports Third Quarter 2014 Financial Results 5Capnia Reports Third Quarter 2014 Financial Results 6Capnia Reports Third Quarter 2014 Financial Results 7Capnia Reports Third Quarter 2014 Financial Results 8Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 2Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 3
... BOSTON, Nov. 7, 2011 PAREXEL International Corporation (NASDAQ: ... at the Lazard Capital Markets Healthcare Conference in New York. ... making a presentation on PAREXEL at 11:30 a.m. ET on ... presenting at the Citi Small/Mid Cap Conference in Las Vegas. ...
... USA Corporation, the world,s leading provider of medical education ... healthcare industry, is proud to introduce three new ... Hysterectomy module for the LAP Mentor™ and the new ... will be demonstrated at Simbionix booth #1103 at the ...
Cached Medicine Technology:PAREXEL International to Present at Lazard Capital Markets Healthcare Conference and Citi Small/Mid Cap Conference 2Simbionix to Introduce Three New Women's Health Products 2Simbionix to Introduce Three New Women's Health Products 3
(Date:12/20/2014)... (PRWEB) December 20, 2014 Dress company LunaDress ... dresses, and announced its Christmas Sale, offering big discounts on ... “Every girl has an idea to own a perfect wedding ... for your wedding dress, then come to LunaDress. Many different ... for you. Visit our website now and enjoy the current ...
(Date:12/20/2014)... (PRWEB) December 20, 2014 The print ... Post, with a distribution of approximately 160,000 copies and ... distributed nationally through a vast social media strategy and ... outlets. To explore the digital version of the campaign, ... exclusive interview with the ladies of CTV’s The ...
(Date:12/20/2014)... (PRWEB) December 20, 2014 Recently, VogueQueen.com, ... its VogueQueen Big Sale Online for 2015. ... products. All new and old consumers can get a ... order at the company’s website before January 30, 2015. ... prom dresses and launched a prom dress promotion. Many ...
(Date:12/20/2014)... Angeldress.co.uk, the distinguished wedding dress manufacturer and ... fans. The company has recently updated its official blog ... holiday season, Angeldress Blog has recommended some ... Angeldress.co.uk prides itself in offering a huge selection of ... the company’s outfits are very carefully selected based on ...
(Date:12/20/2014)... San Francisco, CA (PRWEB) December 20, 2014 ... a Social Innovation company just launched first birthday focused ... the services, “MERRY BIRTHDAY MESSAGE” launched in both US ... , MERRY BIRTHDAY MESSAGE : http://merrybirthday.net/message/ , ... launching for everyone’s birthday around the world. , Features, ...
Breaking Medicine News(10 mins):Health News:2015 Collection of Wedding Dresses from LunaDress Online on Sale Now 2Health News:The ladies of The Social urge Canadian women to put themselves first over the holiday season and into the new year in Mediaplanet’s “Women’s Health” campaign 2Health News:VogueQueen Big Sale Online For The Coming 2015 2Health News:Trendy Professional Wedding Apparel Recommended by Angeldress Blog 2Health News:Atore, Inc. Releasing the First Birthday Portal 2
... that could stop the growth of glioblastoma, a deadly form ... journal Cell , a Cell Press publication, a new ... allows them to grow and seed tumors. Importantly, normal stem ... that same dependency. "When thinking about therapeutics [targeting cancer ...
... entomology, Bradley Mullens , a professor of entomology at ... of the prestigious Entomological Society of America (ESA), ... scientific needs of entomologists and people in related disciplines. ... were elected to this honor. They will be recognized at ...
... , WEDNESDAY, July 6 (HealthDay News) -- For the millions ... to alleviate the condition has yet to be identified, a ... therapy (SMT) to other treatments such as medication, exercise or ... to be no better or worse than other options at ...
... a suitable donor for leukemia and lymphoma patients who ... that results of two clinical trials show transplant results ... comparable to fully matched tissue, thanks in large part ... post-transplant chemotherapy. The finding means that nearly all ...
... acquisition of speech, but 2 of every 1000 children ... treatment can help these children learn to speak. In ... Martin Ptok of Hannover Medical School explores whether screening ... early diagnosis, and the potential risks of newborn hearing ...
... , THURSDAY, July 7 (HealthDay News) -- Expanding ... use, improves health and well-being and reduces the ... health coverage, according to new research. "This ... and use of care for low-income adults relative ...
Cached Medicine News:Health News:To combat deadly brain cancer, target the stem cells 2Health News:UC Riverside faculty member elected fellow of Entomological Society of America 2Health News:Study Questions Chiropractic's Impact on Back Pain 2Health News:Study Questions Chiropractic's Impact on Back Pain 3Health News:Half-matched transplants widen pool of donors for leukemia and lymphoma 2Health News:Half-matched transplants widen pool of donors for leukemia and lymphoma 3Health News:Medicaid Coverage 'Substantially' Improves Access to Care: Study 2
... a cruciate sparing version which provides ... both resurfacing and inset patellas. Precision ... and fit with tibial articular surface ... cutting guide peg locations provide easy ...
The Balanced Knee System provides instrumentation designed to achieve proper tissue balancing and alignment with user-friendly instrumentation that provides reproducible results....
Advance Posterior Stabilized Total Knee systems improves patellofemoral kinematics, reduces wear rate potential, increases resistance to posterior tibial dislocation, achieves at least 120o flexion i...
... The Duracon tibial inserts have radiused ... advanced 4-axis machining, maximizing conformity of ... condyles of the femoral component. The ... the Duracon system, and accommodates the ...
Medicine Products: