Navigation Links
Genetic and Proteomic Advances Pave the Way for Next-Generation Leukemia Therapies
Date:12/10/2011

ould recognize lymphoma and leukemia cells that express the surface protein CD19, a research team from the National Cancer Institute (NCI) and Sunybrook Odette Cancer Center in Toronto conducted a study using gene therapy methodology to induce patient-derived T-cells to express anti-CD19 CAR-encoding genes so that the T-cells could recognize and destroy the B-cell lymphomas and leukemias that express CD19.

A total of eight patients enrolled in the study were infused with autologous T-cells expressing the CAR, designed to specifically target CD19. Researchers treated four chronic lymphocytic leukemia (CLL) and four B-cell lymphoma patients with chemotherapy and then infused them with the genetically engineered T-cells followed by a high dose of IL-2 (interleukin-2, therapy which stimulates growth of T-cells). After this infusion, CAR-expressing T-cells were detected in the blood of all patients.

One CLL patient achieved complete remission that remained ongoing at 15 months after treatment; one CLL patient attained stable disease; and another five patients achieved partial remission. A marked depletion in CD19+ cells, suggesting that the T-cells successfully targeted and reduced the malignant cells, was found in four of the eight patients, an effect that remained at 15 months post treatment. However, patients experienced significant toxicity during the first 10 days after treatment, the most prominent of which was abnormally low blood pressure.

"While this gene technology is in the early stages of development and we need to improve the toxicity profile, our study validates that it has a potent ability to eliminate the specific cells being targeted, an important basis for future research," said lead author James N. Kochenderfer, MD, Assistant Clinical Investigator at the Experimental Transplantation and Immunology Branch at NCI in Bethesda, Md. "We believe that with these positive results we can explore a wide range of opportunities and pot
'/>"/>

SOURCE American Society of Hematology
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Signal Genetics Announces Launch of Next Generation Genetic Multiple Myeloma Predictive Testing Product-MyPRS Plus™
2. VolitionRX Subsidiary Enters Into its First Revenue-Generating Agreement to Profile Blood-Based Epigenetic Signatures
3. Abbotts Genetic Test for Acute Myeloid Leukemia Prognosis Cleared by FDA
4. Novel New Dog DNA Test Turns Breeders Into Genetic Matchmakers
5. Genetic Profile Identified for Alzheimers Patients Showing Heightened Response to Acceras Breakthrough Product Axona®
6. Good Start Genetics to Announce Validation Study Results for its Next-Generation DNA Sequencing Platform During an Oral Presentation at the 2011 Annual Meeting of the American Society for Reproductive Medicine (ASRM)
7. American College of Medical Genetics Applauds HHS Secretarys Decision to Expand Newborn Screening to Include Critical Congenital Heart Disease
8. Ambry Genetics Announces Launch of Their CancerArray™ Product and Services Utilizing aCGH Technology
9. The Leukemia & Lymphoma Society Available to Comment on FDA Approval of Seattle Genetics Adcetris, First New Treatment for Hodgkin Lymphoma Since 1977
10. Genetic Testing Can Help the US Cut Costs and Improve Health Care
11. Metamark Genetics Announces Cancer Cell Study Highlighting Discovery of Key Molecules that Drive Progression of Malignant Melanoma in Humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... Oct. 17, 2014  Training market researchers to ... success factor in today,s highly competitive global marketplace. ... organizations that effectively and efficiently produce high performing ... area. Effective training programs can ... recognition from internal clients by developing analysts who ...
(Date:10/17/2014)... 17, 2014 Research and Markets ... and Development Prospect of China Dialysis Market, 2014-2018" ... Based on the 2013 version, this update Report ... dialysis industry and the relevant effect in recent ... industry segmentations. Moreover, it analyzes Chinese private-owned hemodialysis ...
(Date:10/17/2014)... Oct. 17, 2014 The following is ... Policy: The Green Park Collaborative (GPC) ... and private payers, medical device and pharmaceutical companies, ... experts January 12, 2015 at its first ever ... weight loss treatments.  Participants will discuss study designs ...
Breaking Medicine Technology:Effective Training Programs for Market Research Groups can Boost Overall Organizational Success 2Research and Development Prospect of China Dialysis Market, 2014-2018 2Research and Development Prospect of China Dialysis Market, 2014-2018 3Green Park Collaborative to Discuss Comparative Effectiveness and Value of Weight Loss Treatments 2
... 23, 2011 Varian Medical Systems (NYSE: VAR ... at the annual meeting of the American Society for Radiation ... financial community are invited to join senior management for a ... will host a meeting with management, beginning with breakfast at ...
... NEW YORK, Aug. 23, 2011 ITelagen, Inc., a leading ... that the company was named to the prestigious 2011 Inc. ... growing companies in America. This was the second ... 5000 and was placed on the list at position #2093, ...
Cached Medicine Technology:Varian Medical Systems Schedules Investor Meeting at ASTRO in Miami Beach, FL 2ITelagen Named to Prestigious 2011 Inc. 5000 List of Fastest-Growing Companies 2
(Date:10/20/2014)... Los Angeles, CA (PRWEB) October 20, 2014 ... embodies fitness expertise, nutritional coaching, corporate wellness programming, authorship, ... MS, CPT, is excited to announce the release of ... , After many years of coaching thousands of ... pioneering nutrition tracking app that does not require calorie ...
(Date:10/20/2014)... October 20, 2014 AttorneyOne.com, a recognized authority ... information from the FDA on Sit and Slim II ... not to purchase or use Sit and Slim II because ... II is promoted as weight loss product on various websites ... the market in 2010 for safety reasons, can significantly increase ...
(Date:10/20/2014)... Succeed is proud to announce that they ... in the Every Body Walk! campaign by Kaiser ... that encourages workers to be more active outside of the ... concluded at the end of September, was a friendly competition ... areas. Participating companies gave their staff pedometers and each ...
(Date:10/20/2014)... October 20, 2014 Final Cut Pro X ... of the Citrus theme for FCPX filmmakers . , ... to describe the Citrus theme” Says Christina Austin, CEO of ... look so professional.” , Citrus comes with all the tools ... template are: four transitions for added style, a title screen ...
(Date:10/20/2014)... Punzoné , the first line of ultra-premium organic ... to celebrate this month. October marks Italian Heritage Month – ... of Americans of Italian heritage and Italians in America. October ... its favorite Italian cocktails and encourages everyone to enjoy its ... it is only in a glass. , Punzoné continues ...
Breaking Medicine News(10 mins):Health News:JZ Fitness Nutrition App Launches on iTunes 2Health News:JZ Fitness Nutrition App Launches on iTunes 3Health News:FDA Advises Not to Use Sit and Slim II: AttorneyOne Monitors and Keeps Consumers Informed 2Health News:Succeed Management Solutions, LLC Competes in Walking Challenge and Achieves 12th Place in Portland 2Health News:Today Pixel Film Studios Announced the Release of the Citrus theme for Final Cut Pro X 2Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 2Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 3Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 4
... Anticipating the needs of,the future, Geneva College will ... in the nation., Drawing on Geneva,s long-standing ... the program offers students a M.S. degree in,Cardiovascular ... of obtaining a B.S. (in four years) or ...
... 28, 2008 Oxytocin was originally studied as the ... for breast-feeding. However, there is increasing evidence that ... bonding and maternal behaviors. A new study scheduled ... Biological Psychiatry now shows that one way oxytocin ...
... of Liverpool has found that hypnosis can slow down ... for those living with the condition. , Forensic psychologist, ... people living with dementia and compared the treatment to ... hypnosis compared to a type of group therapy in ...
... MASummer on Cape Cod is synonymous with a surge ... the MBL (Marine Biological Laboratory). For more than a ... from around the world to immerse themselves in biological ... organisms available for study and the wealth of experts ...
... more resistance, study found , , MONDAY, July 28 (HealthDay ... even act out when nurses or other caregivers use ... , Researchers who taped the interactions of nursing home ... residents often became more agitated and resistant to care ...
... LLC launches new website offering convenient http://www.terrimilen.com [Online Counseling ... the comfort of their own home or office. , ... ... to provide clients with an alternative to traditional therapy which requires ...
Cached Medicine News:Health News:Geneva Offers First Cardiovascular Technology Graduate Program in the Nation 2Health News:A hormone that enhances one's memory of happy faces 2Health News:LabBits: A media tip sheet from the MBL in Woods Hole 2Health News:LabBits: A media tip sheet from the MBL in Woods Hole 3Health News:LabBits: A media tip sheet from the MBL in Woods Hole 4Health News:Alzheimer's Patients React Poorly to 'Elderspeak' 2Health News:Alzheimer's Patients React Poorly to 'Elderspeak' 3Health News:Online Counseling and Life Coaching Practice Launches New Website 2
... of Surgical Microscope Accessories includes digital camera ... cables, and fiberoptic retrofits. TTI Medical's patented ... 5,264,928) is the only adaptor that will ... the same adaptor body. It is fully ...
... Electronic Medical Record system. It stores patient chart ... and everything you would normally put in a ... Someone has to write them, file them, find ... Paper Charts get lost. They find their way ...
RESTASIS® (cyclosporine ophthalmic emulsion) 0.05% is the first and only therapy for patients with keratoconjunctivitis sicca (Dry Eye Disease) whose tear production is presumed to be supressed d...
... WAVEFRONT ANALYZER provides a complete ... the entire eye. Real-time measurements ... aberrations in many different forms ... higher order aberrations, Zernike polynomials, ...
Medicine Products: