Navigation Links
Genetic and Proteomic Advances Pave the Way for Next-Generation Leukemia Therapies
Date:12/10/2011

(19 months vs. 34 months on average in DA arm vs. DAGO arm).

The treatment protocol had some toxicity, as the rate of fatal adverse events possibly attributable to treatment was 6.7 percent in the DA group and 8.7 percent in the DAGO group. Prolonged grade 3 or greater thrombocytopenia was observed in 19 DAGO patients, and three episodes of veno-occlusive disease or sinusoidal obstructive syndrome (liver vein blockages) were observed in the DAGO arm, two noted as fatal.  There were no differences between the arms in the incidence of severe sepsis or in the rate of intensive care unit admission during the course of therapy.

"Research has demonstrated that GO has very potent anti-cancer properties, and with this study we have identified a dosing regimen that gives patients the therapeutic benefit without some of the toxicities previously reported at higher doses," said lead author Sylvie Castaigne, MD, Professor in the Department of Hematology at Hopital de Versailles in Versailles, France. "Specialists treating AML have not been offered a new therapeutic option for several decades, and with this research we are encouraged that GO may be able to deliver better overall outcomes for these AML patients with limited alternatives."

Dr. Castaigne will present this study during the Plenary Scientific Session on Sunday, December 11, at 3:45 p.m. PST at the San Diego Convention Center in Hall AB.

Novel Chromosomal Rearrangements and Sequence Mutations in High-Risk Ph-Like Acute Lymphoblastic Leukemia [Abstract 67]

A recent study focusing on a unique subtype of high-risk B-cell acute lymphocytic leukemia (ALL) has used advanced genome sequencing to identify new targets for the treatment of this deadly blood cancer.

ALL is the most common pediatric malignancy, representing almost one-third of all childhood cancers. In particular, relapsed B-cell
'/>"/>

SOURCE American Society of Hematology
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Signal Genetics Announces Launch of Next Generation Genetic Multiple Myeloma Predictive Testing Product-MyPRS Plus™
2. VolitionRX Subsidiary Enters Into its First Revenue-Generating Agreement to Profile Blood-Based Epigenetic Signatures
3. Abbotts Genetic Test for Acute Myeloid Leukemia Prognosis Cleared by FDA
4. Novel New Dog DNA Test Turns Breeders Into Genetic Matchmakers
5. Genetic Profile Identified for Alzheimers Patients Showing Heightened Response to Acceras Breakthrough Product Axona®
6. Good Start Genetics to Announce Validation Study Results for its Next-Generation DNA Sequencing Platform During an Oral Presentation at the 2011 Annual Meeting of the American Society for Reproductive Medicine (ASRM)
7. American College of Medical Genetics Applauds HHS Secretarys Decision to Expand Newborn Screening to Include Critical Congenital Heart Disease
8. Ambry Genetics Announces Launch of Their CancerArray™ Product and Services Utilizing aCGH Technology
9. The Leukemia & Lymphoma Society Available to Comment on FDA Approval of Seattle Genetics Adcetris, First New Treatment for Hodgkin Lymphoma Since 1977
10. Genetic Testing Can Help the US Cut Costs and Improve Health Care
11. Metamark Genetics Announces Cancer Cell Study Highlighting Discovery of Key Molecules that Drive Progression of Malignant Melanoma in Humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... Aug. 22, 2014   Zacks Equity Research highlights Epizyme ... the Day and Panera (Nasdaq: PNRA - Free Report ) ... provides analysis on Amicus Therapeutics (Nasdaq: FOLD - Free Report ... (Nasdaq: SHPG - Free Report ). Here is ... of the Day : The biotech bull market ...
(Date:8/22/2014)... Research and Markets has announced the addition ... Report 2014" report to their offering. ... 2014 is a professional and in-depth study on the ... a focus on the Chinese situation. The report ... classifications, applications and industry chain structure. The particulate respirators ...
(Date:8/22/2014)... , Cali ., Aug. 22, 2014 ... Papillomavirus Conference shows that a therapy being developed by Hera ... two that cause 70 percent of all cervical cancer. ... blocked the replication of HPV-16, HPV-18 and HPV-11 cells, according ... Broker , Ph.D., who presented the findings at the ...
Breaking Medicine Technology:Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 3Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 4Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 5Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 6Global and Chinese Particulate Respirators Industry Report 2014 2Study shows Hera Therapeutics experimental compound shuts down human papillomavirus that causes most cervical cancer 2
... DIEGO, Jan. 31, 2011 Volcano Corporation (Nasdaq: ... of Massachusetts has issued a decision that ruled in ... Inc., and against LightLab Imaging, Inc., on all of ... 11-page decision also rejected LightLab,s request for injunctive relief. ...
... its continuing partnerships with Brazilian public health authorities and ... Mr. Nelson dos Santos as interim vice president of ... nonprofit organization whose mission is to improve the health ... programs that help ensure the quality, safety and benefit ...
Cached Medicine Technology:Massachusetts Court Rules in Favor of Volcano and Against St. Jude Medical Subsidiary in Trade Secrets Case 2New Interim Leadership for USP-Brazil 2
(Date:8/22/2014)... 265,000 Danes are acutely admitted to medical departments with ... and Aarhus University Hospital now shows that many of ... are sent home again without receiving a diagnosis of ... "Naturally, there is no need for a diagnosis if ... a serious illness. So some patients will always be ...
(Date:8/22/2014)... nurses at New York University,s Langone Medical Center (NYULMC) ... the youngest and most vulnerable down flights of stairs ... generated by Hurricane Sandy. , Now, a recent ... of Nursing (NYUCN) and of Dentistry (NYUCD), published in ... impact on NYULMC nurses, post-Sandy deployment to help address ...
(Date:8/22/2014)... August 22, 2014 Human induced pluripotent ... of regenerative medicine because they can be coaxed to ... always act as anticipated. They sometimes mutate, develop into ... a new study recently published in STEM CELLS Translational ... this, simply by removing the material used to reprogram ...
(Date:8/22/2014)... low levels of nicotine may reduce addiction without ... new study from the University of Waterloo. ... Cancer Epidemiology monitored the smoking behaviours of ... of cigarettes with markedly reduced nicotine levels. , ... of which have very similar levels of nicotine ...
(Date:8/22/2014)... 2014 Lincolnshire Marriott Resort is inviting ... a tap, announcing Marriott’s new iPad Mini promotion for ... this exclusive offer will receive a complimentary iPad Mini ... the day’s agenda with ease. Marriott’s Meeting Services app, ... and connect with their group with just a few ...
Breaking Medicine News(10 mins):Health News:Many patients are discharged without a diagnosis 2Health News:Study identifies challenges faced by NYU nurses after Hurricane Sandy 2Health News:Study identifies challenges faced by NYU nurses after Hurricane Sandy 3Health News:Removing Programming Material After Inducing Stem Cells Could Improve Their Regeneration Ability 2Health News:Smokers consume same amount of cigarettes regardless of nicotine levels 2Health News:Lincolnshire Marriott Resort Offers iPad Mini for Chicago Meeting Planners 2
... Oct. 5 "The good news is,that there ... Terry D. Hashey,Medical Director of First Coast Family ... Corral Flu Campaign. "The bad news,is that despite ... still,ranked below the national average of 69.3% for ...
... dietary supplement ... LipidShield Plus(TM), MELBOURNE, Fla., Oct. ... has expanded again and LipidShield Plus(TM) is,now available at Stop & ... breakthrough cholesterol,fighting product that has been clinically proven to lower cholesterol ...
... Oct. 5 /Xinhua-PRNewswire/ -- In a star-studded ... Olympics honored twelve,extraordinary individuals and the city ... made and continue to make to promote ... of people with intellectual,disabilities, and the Special ...
... SOUTH SAN FRANCISCO, Calif., Oct. 4 Sunesis,Pharmaceuticals, Inc. ... inducement stock options awards in accordance with NASDAQ,Marketplace Rule ... stock options cover an aggregate of 48,000 shares of,common ... an,exercise price equal to the fair market value of ...
... Calif., Oct. 4 The Integrated Healthcare,Association ... to physician,groups in California at its annual ... 47 most outstanding physician groups were,honored for ... care,quality measures, including preventive care and chronic ...
... HealthShares(TM) Inc., an investment,company with a series ... been informed by Standard & Poor,s, the calculating ... at the opening of,trading on October 8, 2007, ... (NasdaqGS: FOXH) in the,HealthShares(TM) Cardio Devices Index. ...
Cached Medicine News:Health News:Florida Health Care Community Stepping Up for the 2007-2008 Flu Season 2Health News:New Health Corp. Announces the Addition of Stop & Shop and Giant Supermarkets to its Retail Outlets 2Health News:Special Olympics 'Special Spirit in China Award Of Excellence' Presented to Dedicated Friends of Special Olympics and City of Shanghai 2Health News:Sunesis Pharmaceuticals Reports New Option Grants Under NASDAQ Marketplace Rule 4350 2Health News:California Physician Groups Recognized by Integrated Healthcare Association (IHA) 2Health News:California Physician Groups Recognized by Integrated Healthcare Association (IHA) 3Health News:California Physician Groups Recognized by Integrated Healthcare Association (IHA) 4Health News:HealthShares(TM) Announces Change to the HealthShares(TM) Cardio Devices Index 2Health News:HealthShares(TM) Announces Change to the HealthShares(TM) Cardio Devices Index 3
... Novagen's Vacuum Manifold system for sample ... to which a vacuum is applied, a ... accessories for convenience in sample handling. The ... elution of up to 12 samples simultaneously. ...
For regulating sample flow rate when using the QIAvac 24 Plus;...
For processing mini spin columns on QIAvac 6S;...
For monitoring vacuum pressure, suitable for use with all QIAvac manifolds;...
Medicine Products: