Navigation Links
Genetic Profile Identified for Alzheimer's Patients Showing Heightened Response to Accera's Breakthrough Product Axona®

BROOMFIELD, Colo., Oct. 17, 2011 /PRNewswire/ -- Accera, Inc., a biotech company specializing in cognitive health, announced today that it has identified the genetic profile of Alzheimer’s disease (AD) patients who have a high probability of responding to Axona® (AC-1202), a prescription medical food product available at pharmacies nationwide.

In this current study, variances in the DNA sequences associated with the genes responsible for producing insulin degrading enzyme (IDE) and the pro-inflammatory cytokine interleukin-1beta (IL1B) were shown to be highly predictive for improvement in cognition among patients receiving Axona.  

Other studies have shown a correlation between an increased risk for AD among carriers of the apolipoprotein E4 allele (APOE4), and Accera has previously published its findings from a double-blind, placebo-controlled study showing that AD patients who were non-carriers of the APOE4 gene (APOE4(-)) experienced significant cognitive improvements in a 90-day trial of AC-1202.  This additional analysis has shown that specific genotype combinations of E4(-), IDE and IL1B produced additive improvements in cognitive performance.  

Alzheimer's patients who carried combinations of common variants in IDE, APOE and IL1B showed as much as a 7 point increase in cognitive function as measured by the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog), one of the most widely used scales for anti-dementia drugs in the US.  Changes in the ADAS-cog scores of more than 3-4 points are generally recognized as being clinically meaningful.  Since the specific variations in the genes for IDE and IL1B are commonly observed in the AD population, the number of patients who are likely to experience a heightened therapeutic benefit from Axona should be significant.

This result was particularly surprising because the majority of participants in the study were already taking one or more approved Alzheimer's disease medications. "More than two dozen clinical trials have demonstrated that certain therapies offer clear genotype dependent clinical improvements," commented Dr. Judes Poirier of McGill University.  Dr. Poirier is internationally renowned for his works on the role of apolipoprotein E in the normal and injured brain, and in the genetics of Alzheimer's disease.  According to Dr. Poirier, "this study takes this notion to the next level, linking multiple genetic risk factors to significant therapeutic response in a state-of-the-art, randomized, double-blind, placebo controlled study in mild-to-moderate Alzheimer's disease."

Alzheimer's disease is characterized by decreases in the brain's ability to metabolize glucose, a well recognized condition known as hypometabolism.  Since glucose is the predominant fuel used by the brain, disruptions in glucose metabolism are associated with cognitive impairment.  Axona, a medical food product taken once daily, overcomes this deficiency by providing the brain with ketone bodies, an alternative fuel source that results in improved cognition.  

Dr. Richard Isaacson, Associate Professor of Clinical Neurology at the University of Miami Miller School of Medicine and author of the book "Alzheimer's Treatment / Alzheimer's Prevention: A Patient and Family Guide" also finds these results encouraging.  Dr. Isaacson explains that "clinicians have been struggling to understand why certain patients with Alzheimer's disease may preferentially respond to one therapy, while other patients will not respond.  This exploratory study is important in that it takes the first steps toward understanding how specific genes may influence the response to ketosis therapy, and improve our ability to address glucose hypometabolism in the brain."

 The title of the article is "Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study" and is freely available at (

About Alzheimer's disease

AD significantly impacts millions of family members and other caregivers – mentally, physically and financially. The national Family Caregiver Alliance estimates that approximately 80 percent of caregivers provide unpaid assistance seven days a week. With the lack of innovative new medications for AD, both patients and caregivers are seeking alternatives to improve quality of life.

About Axona®

Axona is a first-in-class medical food for the clinical dietary management of the metabolic processes associated with mild-to-moderate Alzheimer's disease. Dispensed by prescription, Axona targets the metabolic deficiencies and imbalances associated with Alzheimer's disease by providing an alternative energy source for brain cells. With simple administration and once-a-day convenience, Axona is complementary to current Alzheimer's disease therapies.  For more information about Axona, please visit or contact a doctor who is familiar with the product.

About Accera, Inc.  

Accera, Inc. is a privately held commercial-stage cognitive health company that developed and now markets Axona in the US. Axona is a prescription-only medical food intended for the clinical dietary management of the metabolic processes associated with mild-to-moderate Alzheimer's disease.  In clinical trials, Axona has been shown to safely improve cognitive function and memory in AD patients.  Axona addresses the hypometabolism or defective metabolism of glucose that occurs in those areas of the brain that are involved in Alzheimer's disease.  Accera engages in research, development and commercialization of other clinical applications for Axona.

For more information about Accera, please visit

Accera, Inc.
Samuel Henderson
Vice president of Research and Development

Tiberend Strategic Advisors, Inc.
(212) 827-0020
Andrew Mielach
Madeleine Desmond

SOURCE Accera, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Good Start Genetics to Announce Validation Study Results for its Next-Generation DNA Sequencing Platform During an Oral Presentation at the 2011 Annual Meeting of the American Society for Reproductive Medicine (ASRM)
2. American College of Medical Genetics Applauds HHS Secretarys Decision to Expand Newborn Screening to Include Critical Congenital Heart Disease
3. Ambry Genetics Announces Launch of Their CancerArray™ Product and Services Utilizing aCGH Technology
4. The Leukemia & Lymphoma Society Available to Comment on FDA Approval of Seattle Genetics Adcetris, First New Treatment for Hodgkin Lymphoma Since 1977
5. Genetic Testing Can Help the US Cut Costs and Improve Health Care
6. Metamark Genetics Announces Cancer Cell Study Highlighting Discovery of Key Molecules that Drive Progression of Malignant Melanoma in Humans
7. Metamark Genetics Partners with Definiens on Tissue-Based Cancer Diagnostics
8. Signal Genetics and DiagnoCure Announce a US$13.3M Collaboration for the Commercialization of Previstage™ GCC Colorectal Cancer Staging Test
9. Research 2.0 Updates Coverage of Viral Genetics with Research Report Focused on VG Energy
10. Viral Genetics Updates HIV/AIDS and Drug Resistant Cancer Research Programs
11. Genetic Technologies Processes First BREVAGen™ Patient Sample
Post Your Comments:
(Date:10/13/2015)... Oct. 13, 2015  SeraCare Life Sciences, a leading ... that the company,s precision medicine business unit has launched ... materials for next-generation sequencing (NGS)-based tumor profiling assays.  The ... the same mixture of mutations in key oncogenes and ... AF20 mix , but is offered at five additional ...
(Date:10/13/2015)... 2015  Graduate students across the country, with ... will soon have the opportunity to learn about ... drug discovery and development process. Eli Lilly and ... 10 leaders from academic institutions to create an ... of Drug Development."  Lilly will formally unveil the ...
(Date:10/13/2015)... WASHINGTON , Oct. 13, 2015 /PRNewswire/ ... the first-ever direct-to-consumer laboratory home testing kit ... and digital technologies provide an unparalleled, detailed ... of breast milk—fats, proteins, carbs and key ... digital portal for personal health tracking.  In addition, ...
Breaking Medicine Technology:
(Date:10/13/2015)... ... October 13, 2015 , ... ... management services, today announced its partnership with WPC Healthcare , a provider ... systems and organizes the data into an aggregated data repository necessary to perform ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... announced today their sponsorship of the Microsoft Dynamics AXUG, GPUG and NAVUG Summits ... GPUG Summit and NAVUG Summit are independent user conferences designed and led by ...
(Date:10/13/2015)... ... 13, 2015 , ... Relay (, a technology company that ... significant contract that will provide its award-winning private messaging solution to Independence Blue ... success of its Relay program, IBX Wire™, which now has over 550,000 members ...
(Date:10/13/2015)... ... ... A child without a healthy mouth is much more likely to have ... system, has joined with Global Dental Relief (GDR) to help bring dental ... purchased, SmileCareClub will donate one clinic visit to a child in Kenya. , “When ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... targets the unique health needs of new moms. Postnatal Omega-3, which has ... ), utilizes Nordic Naturals’ exclusive, new, ultra-concentrated omega-3 oil. This breakthrough ...
Breaking Medicine News(10 mins):