Navigation Links
Genetic Engineering & Biotechnology News Reports on the Growing Role of Ion-Channel Studies in Global Biotech R&D
Date:6/4/2008

NEW ROCHELLE, N.Y., June 4 /PRNewswire/ -- Ion-channel research is drawing increasing attention from a wide variety of life science investigators all over the globe, reports Genetic Engineering and Biotechnology News (GEN). Such interest is not surprising as ion channels play key roles in numerous biological processes such as neural signal transduction, cardiac, skeletal, and smooth muscle contraction, and epithelial transport of nutrients and ions, among others, according to an article in the June 1 issue of GEN (http://www.genengnews.com/articles/chitem.aspx?aid=2484).

"Research on ion channels has opened up possibilities for new ways to treat a host of diseases, including cancer, a malfunctioning immune system, and cardiovascular and metabolic disorders," notes John Sterling, Editor in Chief of GEN.

On the basic research side, Merritt Maduke, PhD, assistant professor in the department of molecular and cellular physiology at Stanford University School of Medicine, has built a lab focused on elucidating the molecular mechanisms underlying the function of the CLC chloride channels, the largest molecular family of mammalian anion channels. Dr. Maduke's interest in the CLC family is that half of the members are chloride channels, while the other half are chloride-proton antiporters.

In the bioindustry, the real challenge in developing therapeutics based on ion-channel research is the size of ion-channel families and their widespread distribution. The ongoing focus for the development of therapeutics with channel specificity is to develop subtype selectivity to improve efficacy and reduce the impact of side effects.

At Devgen, the focus is on treatment for inflammatory and metabolic diseases and arrhythmia. Petra Blom, PhD, section leader within the medicinal chemistry group, and Titus Kaletta, PhD, head of preclinical development, are working on a project targeting the Kv4.3 ion channel. The goal of their work is to develop a first-in-class oral treatment for acute and chronic atrial fibrillation.

Also discussed in the GEN article is ion-channel work at Organon Laboratories, ChanTest, Molecular Devices and Axon Instruments (both now part of MDS Analytical Technologies), Sophion Bioscience, Nanion Technologies, and Flyion.

For a copy of the June 1 issue of GEN, please call 914.740.2122, or email: ebicovny@liebertpub.com

Genetic Engineering and Biotechnology News (http://www.genengnews.com), which is published 21 times a year by Mary Ann Liebert, Inc., is the most widely read biotechnology news magazine worldwide. It includes articles on Drug Discovery, Bioprocessing, OMICS, Biobusiness, and Clinical Research and Diagnostics.

Contact: John Sterling

Editor in Chief

Genetic Engineering & Biotechnology News

914.740.2196

jsterling@genengnews.com


'/>"/>
SOURCE Genetic Engineering & Biotechnology News
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. CellCyte Genetics Corporation Selects Washington University School of Medicine to Perform Study on CellCytes Glycoprotein Products in Heart Attack Disease Model
2. Presentation of Data on Progens Cancer Epigenetic Targets Platform
3. CellCyte Genetics Signs Collaborative Agreement With Northwestern Universitys Feinberg School of Medicine to Perform Disease Model Outcome Study of CellCytes CCG-TH30 Product Candidate
4. Join NPRs David Ewing Duncan, Author Jessica Queller and a Panel of Medical and Legal Experts in a 90-Minute Webcast on Genetic Testing, Genomic Medicine and Breast & Ovarian Cancer
5. deCODE Discovers Novel Genetic Links Between Pigmentation Traits and Risk of Skin Cancer
6. Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics Heart Health Test
7. Genetic Immunity Announces Data Related to the DermaVir Nanomedicine Patch in the Journal of Immunology
8. Preclinical Study Shows CTIs Brostallicins Cancer-Killing Ability Based on Genetic Profiling
9. Genzyme Genetics Announces Launch of Carrier Testing and Prenatal Diagnosis for Spinal Muscular Atrophy
10. Navigenics(TM) Genome Analysis Used In Research Trial on the Impact of Providing Genetic Risk Assessments
11. Ranolazine Shortens QT Interval and Improves Cardiac Relaxation in Study of Patients With Genetic Sodium Channel Disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/8/2017)... MACRA replaces the outdated sustainable growth ... reimbursement. Black Book Research crowdsource-surveyed 8,845 physician practices from ... Market for MIPS Compliance Technology is Booming ... 3 or more clinicians seek to buy Merit-Based Incentive ... magnitude of the changes, the hunt is on for ...
(Date:5/6/2017)... 2017  May is Stroke Awareness Month and Omron ... important methods to prevent a stroke: monitor and manage ... Control and Prevention, undetected and uncontrolled hypertension is a ... global leader in personal heart health technology, recently evolved ... attack and stroke and is advancing a national public ...
(Date:5/4/2017)... 2017  A recent study published in the ... light as a means of disinfection anesthesia workstations ... bioburden on anesthesia workstations. In the study, UVC ... medical equipment surfaces contaminated with three (3) organisms ... study further validates the body of literature supporting ...
Breaking Medicine Technology:
(Date:5/21/2017)... ... May 21, 2017 , ... For more than 20 years United Cutlery has ... knives and swords, from functional to fantasy. United Cutlery has always been “Stronger. Sharper” ... that defy tradition. , Offering a range of weapons and tools built for battle, ...
(Date:5/19/2017)... , ... May 19, 2017 , ... ... health community, Queens University of Charlotte recently began recruitment efforts for the inaugural ... arms students with the skills, knowledge and expertise to approach and address the ...
(Date:5/19/2017)... ... 19, 2017 , ... The Hill Agencies, a family managed firm that offers ... Central Valley, is announcing a joint charity initiative with the Boys and Girls Club ... camp event. , The Boys and Girls Club of Kern County gives young people ...
(Date:5/19/2017)... ... ... As a groundbreaking surgeon on the frontline of prostate cancer treatment, ... of the disease, he says, can make a world of difference. ... the Georgia Comprehensive Cancer Control’s (GC3) Prostate Cancer Task Force and its suggestion to ...
(Date:5/19/2017)... Clara, CA (PRWEB) , ... May 18, 2017 , ... ... that allows sleep labs and physicians to independently dispense CPAP devices and supplies, such ... orders, and sleep labs can dispense the devices. Device registration for daily usage data ...
Breaking Medicine News(10 mins):