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Genetic Differences Predict Anti-Inflammatory Benefits From Nutritional Products
Date:9/25/2007

ng to guide people to healthier nutrition that fits with their genetics."

To view the published paper please visit http://nutritionjrnl.com/inpress

For more information on Interleukin please visit http://www.ilgenetics.com

About the Study

This was a randomized, placebo controlled clinical trial designed to test effects of botanical formulations versus placebo for reduction of inflammatory chemicals in individuals who are genetically predisposed to over-produce inflammation. Healthy adults with elevated C-reactive protein (CRP) levels were stratified into genetic groups based on being either positive or negative for the IL-1 gene variations that are associated with over-expression of IL-1 Beta and increased risk for coronary artery disease events, such as a myocardial infarction. The IL-1 positive and negative subjects were randomized to either a botanical formulation or placebo. The botanical formulation included rose hips, a blueberry and blackberry mixture, and a grape vine extract. This formulation was developed by Access Business Group International LLC by screening hundreds of botanical extracts for their ability to inhibit IL-1 Beta or CRP production. After 12 weeks of dosing with the botanical formulation, the IL-1 Beta gene expression by stimulated peripheral blood mononuclear cells was significantly lower than baseline and significantly lower than placebo in both IL-1 genotype positive and negative subjects. Over the 12 week treatment period, the mean reduction in IL-1 Beta gene expression with the botanical was greater in genotype positive than in the genotype negative subjects. In IL-1 genotype positive subjects, significantly more subjects achieved a reduction in CRP with the botanical mixture than with the placebo. No CRP effect was observed in the IL-1 genotype negative subjects.

About Interleukin

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