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Genetic Differences Predict Anti-Inflammatory Benefits From Nutritional Products
Date:9/25/2007

genetic differences influence responses to certain nutrients or diets, this study is one of very few that selected individuals with different genetic patterns and then tested how each group responded to either a nutrient or a placebo. It certainly appears to be practical to develop botanical products that have significant benefits for specific groups of individuals based on their genetics."

Patients in the study were given either a placebo or a botanical mix one time each day for 12 weeks. The botanical formulation included rose hips, a blueberry and blackberry mixture and a grape vine extract. Inflammation was measured by chemicals found in the white blood cells, initially taken from patients before treatment. White blood cells were then collected every two weeks. Patients who received the botanical formulation had a greater reduction in the inflammatory response by their blood cells than those receiving the placebo, and the botanical effects were greater in subjects who tested positive for the IL-1 genetic variations associated with over-expression of inflammation. In addition, in the genotype positive subjects, significantly more achieved a reduction in blood C-reactive protein (CRP) levels with the botanical mixture than with placebo. No CRP effect was observed in the IL-1 genotype negative subjects.

"We have known for many years that individuals respond differently to nutrients depending on their genetics, but this is one of only a few controlled clinical trials in the field of nutritional genetics. This study shows that botanical products may be developed specifically to modulate the biology of people who test positive for certain genetic factors," said Jose Ordovas, PhD, Professor at the Friedman School of Nutrition Science and Policy at Tufts University and a member of Interleukin's Scientific Advisory Board. "As with all scientific advances I like to see the data replicated in other studies, but this is the type of study we must do if we are goi
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SOURCE Interleukin Genetics
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