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Genesis Biopharma Announces Letter to Shareholders Posted to Website
Date:8/30/2011

href="http://www.ncbi.nlm.nih.gov/pubmed/21498393">http://www.ncbi.nlm.nih.gov/pubmed/21498393.  In partnership with key scientists and clinicians at these cancer medical centers, Genesis Biopharma is developing commercial-scale manufacturing, quality and regulatory systems to allow Contego to be delivered to patients as the standard care autologous cell therapy.

We recently partnered with the NCI by entering into a cooperative research and development agreement (CRADA).  The principal investigator is Steven A. Rosenberg, M.D., Ph.D., Chief, Surgery Branch, Center for Cancer Research of the NCI. While the ACT using tumor infiltrating lymphocytes (TIL) therapy approach is proprietary to the NCI, the principal goal of this CRADA is for Genesis and the NCI to collaborate on the development and evaluation of ACT/TIL for the treatment of patients with metastatic melanoma.  

Specifically this CRADA addresses:  (1) the in vitro development of improved methods for the large-scale generation and selection of TIL with anti-tumor reactivity from patients with metastatic melanoma based on ACT therapies developed by and proprietary to the NCI Surgery Branch; (2) the development of these approaches for large-scale TIL production that are in accord with Good Manufacturing Practice suitable for use in treating patients with metastatic melanoma; and, (3) the development of clinical trials using these improved methods of large-scale TIL production as well as improved patient preparative regimens with the goal of commercializing the ACT/TIL therapy approach for treating patients with metastatic melanoma.

Contego is a ready-to-infuse autologous cell therapy using tumor infiltrating lymphocytes that, following approval by the U.S. Food and Drug Administration, will be administered as an in-patient therapy at major cancer medical centers.  

Our strategy of working in partnership with major cancer medical centers offers seve
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SOURCE Genesis Biopharma, Inc.
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