Navigation Links
Genes Identified That Enhance Tumor Cell Sensitivity to CTI's Cancer Drug Brostallicin
Date:4/20/2009

Identifies potential clinical trial strategies for personalized approach to cancer treatment

SEATTLE, April 21 /PRNewswire-FirstCall/ -- Systems Medicine, LLC (SM), a wholly-owned subsidiary of Cell Therapeutics, Inc. (CTI) (Nasdaq and MTA: CTIC), presented data from a preclinical study, which utilized RNA interference (RNAi) and bioinformatics to identify genetic markers - "contexts of vulnerability" - that enhance the anti-tumor response to the experimental drug candidate brostallicin, at the 2009 American Association for Cancer Research (AACR) annual meeting in Denver, Colorado. "Contexts of vulnerability" refers to the genetic configuration in a patient's tumor that makes it susceptible to a specific drug thus providing the genetic rationale for targeted therapy. The study's objective was to identify molecular determinants of brostallicin's anti-tumor response that could guide clinical development and drug combination studies by incorporating an integrated pharmacogenomics approach. The study was conducted by SM in collaboration with the Translational Genomics Research Institute's Pharmaceutical Genomics Division in Scottsdale, Arizona.

"This study has identified certain patient groups which might be more likely to benefit from therapy with brostallicin and have been invaluable in assisting us in identifying promising clinical development strategies for future development of this novel drug candidate," said Jack Singer, M.D., Chief Medical Officer of CTI. "Ultimately, we believe this approach should shorten the clinical development time and increase the success rate by bringing us closer to being able to offer the right drug to the appropriate patient."

Brostallicin is a small-molecule chemotherapeutic agent with a unique mechanism of action -- it binds to the minor grooves located in the DNA double helix. To identify genes associated with cellular response to brostallicin, a high-throughput RNA interfe
'/>"/>

SOURCE Cell Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine technology :

1. ThermoGenesis Announces MXP Involvement in New Regenerative Medicine Initiatives
2. Why Wait for an Anti-Aging Drug? Researchers Interviewed on CBS-TVs 60 MINUTES Discover Longevinex(R) Nutriceutical Matrix Activates 9-Fold More Longevity Genes than Plain Resveratrol
3. STALLERGENES: Oralair(R) Grasses Obtains a Pediatric MA(1) in Germany
4. OmegaGenesis Unveils Novel Nanotechnology Platform With Broad Biomedical Applications
5. Breakthrough Mapping of Alzheimers Genome Helps ID Four New Suspect Genes
6. Neuronascent, Inc. Receives Multiple Fundings for Its Neurogenesis Therapeutic Programs
7. Cepheid Announces CE IVD Release of First On-Demand Test for van A/van B Genes Most Associated With Hospital-Acquired VRE Infection
8. New Genes Found for Inflammatory Bowel Disease in Children
9. Stallergenes: New Study VO 56 Highly Positive Results Conducted in an Allergen Challenge Chamber
10. Cardiogenesis Announces Preliminary Clinical Results With the PHOENIX System Combining TMR + Stem Cells
11. NARSAD Researchers Identify Specific Genes and Family Traits Linked to Schizophrenia, Bipolar Disorder and Depression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/17/2013)... Fla. , May 17, 2013 Fuse Science, ... delivery technology company that is developing new, patent-pending technologies poised ... announced today that it will hold a business update teleconference ... May 22 nd , 2013 at 4:30 PM ET. ... will host the call and will be joined ...
(Date:5/17/2013)... , May 17, 2013 Oramed ... of oral drug delivery systems, announced today that the ... the Company,s Investigational New Drug application(IND) for ORMD-0801, its ... to have the FDA clearance to proceed," stated ... upcoming trial is a major milestone for Oramed and ...
(Date:5/16/2013)... N.J. , May 16, 2013  PTC Therapeutics, ... statement on Form S-1 with the U.S. Securities and ... offering of its common stock. The number of shares ... offering have not been determined. (Logo:  ... Suisse are acting as joint book-running managers for the ...
Breaking Medicine Technology:Fuse Science, Inc. to Hold Business Update Webcast and Teleconference on May 22nd 2Oramed Receives FDA Clearance to Initiate Oral Insulin Trials in the U.S. 2Oramed Receives FDA Clearance to Initiate Oral Insulin Trials in the U.S. 3PTC Therapeutics, Inc. Files Registration Statement for Proposed Initial Public Offering 2
(Date:5/19/2013)... 6Webs.com is the leader in reviews ... are considering an alarm system can do a comparison ... security system providers online at 6Webs.com. Just recently finishing ... home security system companies, 6Webs.com currently is announcing ... home security companies before ranking the home security system ...
(Date:5/19/2013)... 19, 2013 Americans live closer to ... newest American Veterinary Medical Association (AVMA) U.S. Pet Ownership ... owners consider their dog a member of the family, ... as much five years earlier. , According to the ... the national income dedicated to pets has increased every ...
(Date:5/19/2013)... Los Angeles (PRWEB) May 19, 2013 Yeast ... infections can appear in sensitive areas of the human body. ... by Yeastrol. This new formula provides a unique method of ... This new spray solution is now provided to men and ... Yeast is naturally absorbed in the body through food and ...
(Date:5/19/2013)... Buenos Aires, Argentina: Yoga classes ( clases de Yoga ... by the Sivananda Yoga Vedanta Center. The center ... Norte). Classes are 90 minutes and are offered all ... a calm environment, allowing visitors to enjoy the benefits ... among others. , The Yoga classes follow the following ...
(Date:5/19/2013)... 2013 The Da Vinci robot lawyers ... in the nation’s first trial involving a Da Vinci ... State Superior Court, was filed by the widow of ... complications in a robot-assisted prostate removal, according to a ... robotic surgery lawsuit alleges those complication’s hastened his ...
Breaking Medicine News(10 mins):Health News:Top Rated DIY Home Security System Companies Published by 6Webs.com 2Health News:Dogs Becoming Part of the Family: Dog Bite Injuries Decreasing 2Health News:Dogs Becoming Part of the Family: Dog Bite Injuries Decreasing 3Health News:A Safe & Homeopathic Yeast Infection Relief by Yeastrol Now Available at HealthCareSupplementz.com with Massive Discount 2Health News:Clases de Yoga in Buenos Aires, Argentina (Yoga Classes) Now Offered by Sivananda Yoga Vedanta Center 2Health News:Da Vinci Surgical Robot Lawyers at Wright & Schulte LLC Note Recent Developments in Da Vinci Robot Lawsuit Trial 2Health News:Da Vinci Surgical Robot Lawyers at Wright & Schulte LLC Note Recent Developments in Da Vinci Robot Lawsuit Trial 3Health News:Da Vinci Surgical Robot Lawyers at Wright & Schulte LLC Note Recent Developments in Da Vinci Robot Lawsuit Trial 4
... to experience 25% less muscle and joint pain in their ... study has also revealed that people who regularly participate in ... than non-runners even though they are more likely to suffer ... of the level of pain in a group of runners ...
... belief new studies point in the direction that a dose ... ,"High levels of daily stress are linked to a ... study carried out at the National Institute of Public Health, ... 18 years and asked about their routine levels of stress ...
... Compared to bare metal stents, placement of stents ... of the artery re-narrowing nine months following angioplasty ... to an article in the September 14 issue ... treatment of atherosclerotic coronary artery disease, according to ...
... on findings of a recent study researchers say that certain ... used to help current and former smokers ward off development ... worldwide. ,Researchers say their study provides significant insight ... by which the process can be slowed down after exposure ...
... early detection of breast cancer and the health officials recommend ... of the breasts for lumps every month for early diagnosis ... to start an early treatment which will give better treatment. ... England Journal of Medicine has shown that the newly developed ...
... has shown that there are few clinical comparisons available ... seeking the best individual drug for their children with ... to help make that choice. ,There are few ... relatively large variety of drugs prescribed for ADHD and ...
Cached Medicine News:Health News:Stents That Release Medication To Check Artery Narrowing 2Health News:Digital Mammogram For Detection Of Breast Cancer In Women With Dense Breasts 2Health News:Clinical Comparisons Between ADHD Drugs Are Less 2
... provider of Telemedicine monitoring and diagnostic ... service commitment to patients and prescribing ... testing devices that provide enhanced diagnostic ... standard telephone lines. TransMedEx's product line ...
... Raytel Cardiac Services is a ... uniquely qualified people, combined with state-of-the-art ... clinical information that supports healthcare professionals ... Cardiac Services uses telecommunications and ECG ...
... has developed a new, integrated technology ... heartbeat-by-heartbeat, ECG monitoring, analysis and response, ... service is initially focused on helping ... arrhythmia. Time is of the essence ...
... microplate incubator is an extremely compact ... single microplate up to 50C. ... requiring higher temperatures up to 65C. ... low cost and high performance for ...
Medicine Products: